“…In the last few years, a number of reports from several countries have evaluated the time trends of major atopic diseases by analyzing at least 3 different time-points. 36 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 As can be seen in the Supplementary Fig. 4 , in general terms their results are in agreement with ours in the sense that the frequency of these diseases appear to be decreasing in recent years.…”