Trend in CD4+ Cell Counts at Diagnosis in Human Immunodeficiency Virus-Infected Persons in Korea

Kim, Nam Joong

doi:10.3947/ic.2017.49.2.155

Cited by 3 publications

(3 citation statements)

References 8 publications

(14 reference statements)

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“…The participants in this study still showed high rates of simultaneous infections of syphilis, TB (including mycobacterium TB and non-mycobacterium TB), and pneumocystis pneumonia. Based on the facts that the mean CD4 T cell count at diagnosis was low and 372 (43.7%) of 852 participants had a CD4 T cell count at diagnosis of <200, it can be deduced that the HIV infection was diagnosed late [40]. Studies also revealed that a late HIV diagnosis is likely to cause an active spread of infection to others, as the amount of the virus is not suppressed and missing critical period could lead to less effective treatment, and an increased risk of AIDS and death [41].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of HIV infected Korean: Korea HIV/AIDS Cohort Study

Choi

Kim

et al. 2019

Epidemiol Health

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OBJECTIVESTo manage evidence-based diseases, it is important to identify the characteristics of patients in each country.METHODSThe Korea HIV/AIDS Cohort Study seeks to identify the epidemiological characteristics of 1,442 Korean individuals with human immunodeficiency virus (HIV) infection (12% of Korean individuals with HIV infection in 2017) who visited 21 university hospitals nationwide. The descriptive statistics were presented using the Korea HIV/AIDS cohort data (2006-2016).RESULTSMen accounted for 93.3% of the total number of respondents, and approximately 55.8% of respondents reported having an acute infection symptom. According to the transmission route, infection caused by sexual contact accounted for 94.4%, of which 60.4% were caused by sexual contact with the same sex or both males and females. Participants repeatedly answered the survey to decrease depression and anxiety scores. Of the total participants, 89.1% received antiretroviral therapy (ART). In the initial ART, 95.3% of patients were treated based on the recommendation. The median CD4 T-cell count at the time of diagnosis was 229.5 and improved to 331 after the initial ART. Of the patients, 16.6% and 9.4% had tuberculosis and syphilis, respectively, and 26.7% had pneumocystis pneumonia. In the medical history, sexually transmitted infectious diseases showed the highest prevalence, followed by endocrine diseases. The main reasons for termination were loss to follow-up (29.9%) and withdrawal of consent (18.7%).CONCLUSIONSEarly diagnosis and ART should be performed at an appropriate time to prevent the development of new infection.

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Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of HIV infected Korean: Korea HIV/AIDS Cohort Study

Choi

Kim

et al. 2019

Epidemiol Health

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“…As the incidence of newly infected HIV patients is gradually increasing in Korea [ 19 ], clinicians may encounter more HLH cases among HIV patients in the near future. They should not overlook HIV infection as a possible trigger of secondary HLH.…”

Section: Discussionmentioning

confidence: 99%

A Case of Human Immunodeficiency Virus-triggered Hemophagocytic Lymphohistocytosis Presenting with Severe Bleeding Tendency

et al. 2021

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Human immunodeficiency virus (HIV) is one of the less common triggers of secondary hemophagocytic lymphohistiocytosis (HLH) in which coagulation disorder is a frequent manifestation. Here, we present a case of HIV-triggered secondary HLH presenting with severe bleeding tendency and fever. Despite high-dose dexamethasone infusion (10 mg/body surface area/day), progressive disseminated intravascular coagulation and thrombocytopenia resulted in massive hemathochezia: the bleeding episode ceased after endoscopic hemoclipping. After then, he took a highly-active antiretroviral therapy (HAART). Eventually, body temperature and overall laboratory findings normalized in response to HAART. Clinicians should not overlook HIV infection as a possible trigger of secondary HLH. In such cases, HAART is the core treatment.

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“…By the end of 2017, the reported cumulative number of women with HIV infection in Korea was 1501, including 473 (31.5%) of racial and ethnic minorities. Approximately 60% of women with HIV infection are of reproductive age (15-44 years old) at the time of HIV diagnosis [910]. Fertility issues for women with HIV infection are becoming increasingly important.…”

Section: Introductionmentioning

confidence: 99%

Changing Trends in Pregnancy and Childbirth among Women Living with Human Immunodeficiency Virus at a Tertiary Hospital in Korea: A 28-Year Experience

Kang

Lee

et al. 2019

Infect Chemother

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Background The reports about fertility desire and pregnancy outcome among women infected with human immunodeficiency virus (HIV) in Korea are scarce. This study aimed to determine the changing trend in pregnancy incidence among women infected with HIV in Korea. Materials and Methods We retrospectively reviewed the medical records of women infected with HIV visiting Pusan National University Hospital between January 1990 and October 2018. Results A total of 149 women with HIV infection visited the study hospital. Among them, 33 pregnancies in 24 (16.1%) women were identified. There were 17 live births (51.5%) and 13 abortions (39.4%), whereas 3 women (9.1%) were transferred to another hospital or were lost to follow-up. The number of live birth rose from 0 in 1990-1998 to 17 in 1999-2018. The proportion of repeated pregnancies after HIV diagnosis also increased steeply, from 14.3% in 1999-2008 to 50% in 2009-2018. However, the number of abortions also increased over time. There were 8 induced abortions, 7 (87.5%) of them were diagnosed with HIV infection during pregnancy and 3 (37.5%) were unplanned pregnancies. Eighteen babies, including 1 twin case, were born from 17 births. There was no mother-to-child HIV transmission in our study. Conclusion The number of pregnancies among women with HIV infection and repeated pregnancies after HIV diagnosis has been increasing in Korea, probably due to the desire of HIV patients to have more children. However, the number of abortions also increased, probably due to health concerns and uncertain pregnancy outcome.

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Trend in CD4+ Cell Counts at Diagnosis in Human Immunodeficiency Virus-Infected Persons in Korea

Cited by 3 publications

References 8 publications

Epidemiological characteristics of HIV infected Korean: Korea HIV/AIDS Cohort Study

Epidemiological characteristics of HIV infected Korean: Korea HIV/AIDS Cohort Study

A Case of Human Immunodeficiency Virus-triggered Hemophagocytic Lymphohistocytosis Presenting with Severe Bleeding Tendency

Changing Trends in Pregnancy and Childbirth among Women Living with Human Immunodeficiency Virus at a Tertiary Hospital in Korea: A 28-Year Experience

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