Trend Analysis of the Research on Bee Venom Acupuncture in South Korea, Based on Published Articles

Park

Lee

2019

Toxins

Skin is larger than any other organ in humans. Like other organs, various bacterial, viral, and inflammatory diseases, as well as cancer, affect the skin. Skin diseases like acne, atopic dermatitis, and psoriasis often reduce the quality of life seriously. Therefore, effective treatment of skin disorders is important despite them not being life-threatening. Conventional medicines for skin diseases include corticosteroids and antimicrobial drugs, which are effective in treating many inflammatory and infectious skin diseases; however, there are growing concerns about the side effects of these therapies, especially during long-term use in relapsing or intractable diseases. Hence, many researchers are trying to develop alternative treatments, especially from natural sources, to resolve these limitations. Bee venom (BV) is an attractive candidate because many experimental and clinical reports show that BV exhibits anti-inflammatory, anti-apoptotic, anti-fibrotic, antibacterial, antiviral, antifungal, and anticancer effects. Here, we review the therapeutic applications of BV in skin diseases, including acne, alopecia, atopic dermatitis, melanoma, morphea, photoaging, psoriasis, wounds, wrinkles, and vitiligo. Moreover, we explore the therapeutic mechanisms of BV in the treatment of skin diseases and cytotoxic effects of BV on skin disease-causing pathogens, including bacteria, fungi and viruses.

Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Applications of Bee Venom on Skin Disease and Its Mechanisms: A Literature Review

Park

Lee

2019

Toxins

“…또한 봉약침으로 인 한 부작용인 pain shock 10) , anaphylaxis 11) 등을 줄이기 위 하여 알러지 성분을 제거한 sweet bee venom (SBV) 12) , essential bee venom (EBV) 13) 이 개발되었다. 봉약침의 임상응용에 관한 연구로 Kim 등 14) , Lee 등 15) , Han 등 16) 이 보고한 바 있으며 이 중 Kim 등 14) 은 국내 봉약침 관 련 임상 논문이 비근골격계 질환(34%)에 비하여 근골 격계 질환 관련(66%)으로 주로 편중되어 있음을 보고 하였다. 이러한 임상응용에 대한 연구는 이어져 슬관절 염 17) , 족관절 염좌 18) , 외상상 손상 19) , 척추질환 20 52 Ryu, et al (2003) Effect of intra-articular bee venom injection on synovitis of ankle joint with osteonecrosis of talus: a case report Lee (2004) The comparative study on the bee-venom therapy and common acupuncture therapy for the acute ankle sprain 54 Song (2005) The effect of bee venom acupuncture (BVA) on acute ankle sprain: a randomized controlled trial and double blinding -pilot study 55 Kang, et al (2008) The comparison study between different interventions for treating acute ankle sprain -using dry needle, bee venom acupuncture, hwangryunhaedoktang herbal acupuncture - Table ⅩⅣ).…”

unclassified

A Review of Bee Venom Acupuncture for Articular Diseases of Single Type Joint in the Journal of Korean Medicine

Park

et al. 2021

J Korean Med Rehabil

Objectives This review aims to analyze the current research trend in the usage of bee venom (BV) acupuncture for articular diseases of single type joint. Methods We collected 74 articles on BV acupuncture clinical study for articular diseases of single joint by searching Korean web databases 'Journal of Korean Medicine Rehabilitation', 'Oriental Medicine Advanced Searching Integrated System', 'Korean Traditional Knowledge Portal' from 1999 to 2020 August. Results We summarized the most frequent clinical treatment methods of BV acupuncture for articular diseases of single type joint. Research focused on specific diseases in application of BV acupuncture about some articular type diseases of single joint. It is assumed that the details of treatment for each joint are not related to the type of joint. In clinical study of BV acupuncture, reproducibility was mostly insufficient. Conclusions BV acupuncture clinical study for articular diseases of single joint should be proceed for a number of subjects, to treat various types of disease, by using more safe and detailed treatments.

A clinical literature review and research-trends analysis of bee venom pharmacopuncture for cancer patients

2020

J Korean Med

Objectives: This review aims to investigate clinical studies related to bee venom pharmacopuncture for cancer patients and to analyze the research trend for further study. Methods: We searched for clinical studies using bee venom pharmacopuncture therapy on patients with cancer through the electronic databases including Pubmed, Cochrane library, OASIS, KISS, NDSL, and KMBASE. There was no restriction on language and publication date, and after selection/exclusion process, the study design, target disease, intervention details including acupoints, treatment frequency and period, outcomes, study results and adverse events were extracted. Results: Thirteen clinical studies were finally selected. There were a randomized controlled trial RCT about the effect of sweet bee venom pharmacopuncture on cancer-related pain, and three case series about chemotherapy-induced peripheral neuropathy. In case reports, there were nine studies about oligodendroglioma, plexiform neurofibroma, breast cancer, prostate cancer, lung cancer, urachal adenocarcinoma, malignant melanoma, and atypical squamous cells of undetermined significance. The bee venom therapy affected the improvement of outcomes such as symptoms, quality of life, tumor response, and lab findings. Conclusions: The present study found that bee venom therapy is applicable to the treatment of cancer patients, and showed some effect on various symptoms. However, due to insufficient number and quality of studies, well designed and high-quality clinical trials are necessary to confirm the effectiveness and safety of bee venom pharmacopuncture therapy in patients with cancer.