Tremor: From Pathogenesis to Treatment

Grimaldi, Giuliana; Manto, Mario

doi:10.2200/s00129ed1v01y200807bme020

Cited by 41 publications

(77 citation statements)

References 356 publications

(253 reference statements)

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“…Previous FES tremor suppression research has almost exclusively focused on the wrist due to its importance in daily life activities and since intention tremor affects distal joints more strongly than proximal joints [22], [23]. The underlying dynamics of this joint in response to both tremor and FES are illustrated in Fig.…”

Section: Tremulous Wrist Modelmentioning

confidence: 99%

Repetitive Control of Electrical Stimulation for Tremor Suppression

Copur

Freeman

Chu

et al. 2019

IEEE Trans. Contr. Syst. Technol.

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Abstract-Tremor is a rapid involuntary movement often seen in patients with neurological conditions such as Multiple Sclerosis (MS) and Parkinson's disease. This debilitating oscillation can be suppressed by applying functional electrical stimulation (FES) within a closed-loop control system. However, conventional implementations use classical control methods and have proved capable of only limited performance. This paper establishes the feasibility of embedding repetitive control (RC) action to exploit the capability of learning from experience to completely suppress tremor at the wrist via FES regulated co-contraction of wrist extensors/flexors. A nonlinear model structure and associated identification procedure is first proposed to guarantee stability and performance of the RC system. Then a linearising control approach is developed to facilitate transparent RC design, together with a mechanism to preserve patients' voluntary intention. Experimental evaluation is performed with both unimpaired and neurologically impaired participants using a validated wristrig. For the former group a novel electromechanical system is employed to induce tremor artificially. Results are benchmarked against a well-known classical filtering technique to establish the efficacy of the RC approach. These confirm that the proposed control system with the developed model identification procedure can increase tremor suppression by 43.3% compared with conventional filtering. In addition, the mechanism decreases the interference of RC action with voluntary motion by 20.2% compared with conventional filtering.

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Section: Tremulous Wrist Modelmentioning

confidence: 99%

Repetitive Control of Electrical Stimulation for Tremor Suppression

Copur

Freeman

Chu

et al. 2019

IEEE Trans. Contr. Syst. Technol.

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show abstract

“…On the peripheral circuit the path occurs from muscles to the spinal cord and from the spinal cord to the muscles. On the central circuit the path occurs from peripheral to the spinal cord and supraspinal segments including the brain, cerebellum, basal ganglia and cerebral cortex [10].…”

Section: Understanding the Origins Of Human Tremormentioning

confidence: 99%

“…The neural activity follows rhythmic behavior. Therefore, the cerebral cortex, the basal ganglia, the cerebellum and the brainstem nucleus are all involved in the genesis of tremor [10].…”

Section: Understanding the Origins Of Human Tremormentioning

confidence: 99%

Human Tremor: Origins, Detection and Quantification

Andrade¹,

Pereira²,

Almeida³

et al. 2013

Practical Applications in Biomedical Engineering

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“…По данным рандомизи-рованных исследований [27][28][29], ряд АДР проявляют отчет-ливую активность в отношении паркинсонического тремо-ра, уменьшая его тяжесть в среднем на 30%, при этом прами-пексол имеет, по-видимому, наиболее благоприятный про-филь. Достоверный положительный эффект прамипексола в отношении выраженного лекарственно-резистентного тре-мора при БП у больных со стабильной, оптимизированной схемой противопаркинсонической терапии был убедитель-но продемонстрирован в двойном слепом плацебоконтроли-руемом исследовании [30].…”

Section: сн иллариошкинunclassified

Capacities of the dopamine receptor agonist pramipexole in the treatment of patients with Parkinson’s disease

Иллариошкин¹

2012

Neurology, Neuropsychiatry, Psychosomatics

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Tremor: From Pathogenesis to Treatment

Cited by 41 publications

References 356 publications

Repetitive Control of Electrical Stimulation for Tremor Suppression

Repetitive Control of Electrical Stimulation for Tremor Suppression

Human Tremor: Origins, Detection and Quantification

Capacities of the dopamine receptor agonist pramipexole in the treatment of patients with Parkinson’s disease

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