Tremendous Fidelity of Vitamin D3 in Age-related Neurological Disorders

Association of cord blood vitamin D with child neurodevelopment at 7 years of age

“…In addition, there is uncertainty around the definition of vitamin D insufficiency or deficiency, 74 particularly for neurodevelopment, 14 as well as lack of clearly defined underlying mechanisms through which vitamin D influences neurodevelopment. [12][13][14][15][16][17][18][19][20][21][22] Even the most recent Cochrane review of vitamin D in pregnancy identified 30 trials in over 7000 women (without reporting child neurodevelopment) and found the quality of evidence to be moderate to very low. 75 Future studies should focus on sufficiently large (powered) samples of vitamin D-deficient populations to verify that low vitamin D in pregnancy does not pose a threat to child neurodevelopment.…”

“…11 Some evidence from observational animal and human studies suggests a role of vitamin D for neurodevelopment and functioning, although findings are inconclusive and specific underlying mechanisms driving the association are not well established. [12][13][14][15][16][17][18][19][20][21][22] A number of cohort and case-control studies have reported associations between low vitamin D in pregnancy and/or childhood and increased risk of behaviour problems such as Autism Spectrum Disorder and Attention Deficit Hyperactivity. [23][24][25][26][27] Two reviews of trials of vitamin D supplementation for children with attention-deficit/hyperactivity disorder also found a small decrease in symptoms, although authors noted the quality of evidence was low.…”

From Gut to Brain: Uncovering Potential Serum Biomarkers Connecting Inflammatory Bowel Diseases to Neurodegenerative Diseases

“…In the CNS, vitamin D3 has been found to be synthesized and activated within the brain. It plays a role in gene regulation, inflammation, and cellular proliferation, differentiation, DNA repair, and apoptosis [ 82 , 83 , 84 , 85 ]. It regulates genes involved in calcium homeostasis, oxidative stress, immune response, and neuroprotection.…”

“…In patients with neurodegenerative diseases, low serum levels of vitamin D3 have been observed. Studies have shown that low serum levels of the circulating form of vitamin D are associated with an increased risk of AD, PD, HD, and MCI [ 85 ]. Additionally, vitamin D deficiency has been linked to an increased risk of incident all-cause dementia and AD [ 85 ].…”