2022
DOI: 10.1056/evidoa2100070
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Tremelimumab plus Durvalumab in Unresectable Hepatocellular Carcinoma

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Cited by 448 publications
(508 citation statements)
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References 23 publications
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“…Also, analysis by etiology showed the most favorable outcome was found in patients with non-viral etiology (Fig. 1) [14], a finding completely different from what had been believed.…”
Section: Treatment Effects Of Immune Checkpoint Inhibitors By Etiologycontrasting
confidence: 58%
See 2 more Smart Citations
“…Also, analysis by etiology showed the most favorable outcome was found in patients with non-viral etiology (Fig. 1) [14], a finding completely different from what had been believed.…”
Section: Treatment Effects Of Immune Checkpoint Inhibitors By Etiologycontrasting
confidence: 58%
“…The HR for OS over sorafenib was 0.78 (95% CI, 0.65-0.92). Subgroup analyses of HR for OS were 0.64 (95% CI, 0.48-0.86) in patients with HBV etiology, 1.06 (95% CI, 0.76-1.49) in those with HCV etiology, and 0.74 (95% CI, 0.57-0.95) in those with non-viral etiology [14] (Fig. 1, 2).…”
Section: Durvalumab Plus Tremelimumabmentioning
confidence: 93%
See 1 more Smart Citation
“… 6 , 16 More recently, the combination of a single priming dose of tremelimumab, an anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) mAb, plus durvalumab, an anti-PD-L1 mAb (STRIDE regimen) led to a significant overall survival (OS) advantage over sorafenib in the phase 3 HIMALAYA trial. 17 Of note, single-agent durvalumab was proven non-inferior to sorafenib in the same study. 17 Furthermore, cabozantinib plus atezolizumab significantly improved progression-free survival (PFS), one of the dual primary endpoints of the study, but not OS against sorafenib in the phase 3 COSMIC-312 trial.…”
Section: Introductionmentioning
confidence: 86%
“…The approval of the atezolizumab-bevacizumab combination as the first-line treatment in HCC is the first notable example [19]. Recently, another combinational regimen of tremelimumab-durvalumab was shown to improve the median OS over that of sorafenib treatment in a phase III clinical trial [20]. The second approach is to develop methodologies to select patients who are more likely to derive benefits from the anti-PD-1/PDL-1 treatment.…”
Section: Introductionmentioning
confidence: 99%