TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology

Yu, Chao-Ji; Wang, Meng; Li, Ruiyang; Wei, Tao; Yang, Han-Chen; Yin, Yun; Mi, Ying-Xin; Qin, Qi; Tang, Yi

doi:10.1007/s12035-022-03100-1

Cited by 10 publications

(7 citation statements)

References 102 publications

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“…It found that synaptic loss can be observed in the mild cognitive impairment of AD early stage ( Scheff et al, 2006 ). The basis of normal synaptic function is recognized as synaptic plasticity, and when synaptic plasticity is impaired, information transmission in the CNS is disrupted, leading to impaired cognitive function ( Yu et al, 2022 ). It has been found that Aβ deposition can affect the levels of presynaptic markers and postsynaptic markers which disrupt synaptic plasticity ( Bakota and Brandt, 2016 ; Forner et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Glucagon-like peptide 1 (GLP-1) receptor agonists in experimental Alzheimer’s disease models: a systematic review and meta-analysis of preclinical studies

Kong,

Wu,

Dai

et al. 2023

Front. Pharmacol.

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Alzheimer’s disease (AD) is a degenerative disease of the nervous system. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), a drug used to treat type 2 diabetes, have been shown to have neuroprotective effects. This systematic review and meta-analysis evaluated the effects and potential mechanisms of GLP-1 RAs in AD animal models. 26 studies were included by searching relevant studies from seven databases according to a predefined search strategy and inclusion criteria. Methodological quality was assessed using SYRCLE’s risk of bias tool, and statistical analysis was performed using ReviewManger 5.3. The results showed that, in terms of behavioral tests, GLP-1 RAs could improve the learning and memory abilities of AD rodents; in terms of pathology, GLP-1 RAs could reduce Aβ deposition and phosphorylated tau levels in the brains of AD rodents. The therapeutic potential of GLP-1 RAs in AD involves a range of mechanisms that work synergistically to enhance the alleviation of various pathological manifestations associated with the condition. A total of five clinical trials were retrieved from ClinicalTrials.gov. More large-scale and high-quality preclinical trials should be conducted to more accurately assess the therapeutic effects of GLP-1 RAs on AD.

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Section: Discussionmentioning

confidence: 99%

Glucagon-like peptide 1 (GLP-1) receptor agonists in experimental Alzheimer’s disease models: a systematic review and meta-analysis of preclinical studies

Kong,

Wu,

Dai

et al. 2023

Front. Pharmacol.

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“…Here is increasing evidence supporting the notion that synaptic plasticity plays a prominent role in the establishment and upkeep of learning and memory during development. 37,38 Synaptic plasticity consists of structural and functional changes. Repeated exposure to propofol can potentially impact both facets of synaptic plasticity, although the precise mechanism remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Pretreatment Attenuates Learning Memory Impairment Induced by Repeated Propofol Exposure and Modulates Hippocampal Synaptic Plasticity in Rats

Fan,

Wang,

Gao

et al. 2023

JIR

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Background: Recurrent propofol anesthesia in the peak of neurodevelopment may lead to learning-memory decline. This study aimed to examine the efficacy of electroacupuncture pretreatment in ameliorating the aforementioned learning memory deficits and to explore its underlying mechanisms in a rat model of repeated propofol exposure. Methods: 10-day-old Sprague Dawley rats were randomly assigned to five groups: the control, fat emulsion, propofol, electroacupuncture pretreatment and electroacupuncture pretreatment combined with propofol groups. The electroacupuncture pretreatment involved three consecutive daily sessions, while propofol was received intraperitoneally once daily for five days. Following the modeling period, the rats' learning-memory performance was assessed using the New Novel Arm Y-maze, New Object Recognition, and Morris Water Maze. The Nissl staining method was used to observe the development of hippocampal neurons, while Golgi staining was employed to observe hippocampal synaptic development. Results:The electroacupuncture pretreatment significantly attenuated the learning and memory impairment induced by recurring propofol exposure in rats. Additionally, it facilitated the development of hippocampal neurons and synaptic plasticity in the hippocampus. Immunofluorescence and Western Blot analyses were conducted to detect the expression of proteins related to apoptosis, learning memory, and synaptic plasticity. In the propofol group, the pro-apoptotic factors Caspase-3 and Bax was up-regulated, while the anti-apoptotic factor Bcl-2 was down-regulated, as compared to the blank group. Additionally, the phosphorylated cAMP-response element binding protein (pCREB), brain-derived neurotrophic factor (BDNF), synaptophysin, and growth associated protein-43 (GAP-43) was significantly decreased. In contrast, the electroacupuncture pretreatment combined with propofol group exhibited decreased the Caspase-3 and Bax and increased the Bcl-2, as compared to the propofol group, meanwhile, the pCREB, BDNF, Synaptophysin and GAP-43 was increased. Conclusion:Our findings indicate that electroacupuncture pretreatment can alleviate the learning and memory impairment induced by recurring propofol exposure in rats. This is achieved by enhancing hippocampal synaptic plasticity, activating the pCREB/BDNF pathway and inhibiting neuronal apoptosis.

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“…Microglia are commonly recognized as the brain’s resident immune cells, which are crucial for inflammatory/repair responses in the CNS. Studies have investigated the signaling pathways of microglia-synapse interactions and uncovered the synaptic plasticity regulatory mechanisms of microglia ( Yu et al, 2023 ). The microglia-dependent synapse elimination is a vital phase in the development of neural circuits ( Hansen et al, 2018 ).…”

Section: Influence Of Different Neuronal and Glial Systems On Movemen...mentioning

confidence: 99%

The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review

Li,

Deng,

Jiang

et al. 2024

Front. Neurosci.

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Neurodegenerative diseases refer to a battery of medical conditions that affect the survival and function of neurons in the brain, which are mainly presented with progressive loss of cognitive and/or motor function. Acupuncture showed benign effects in improving neurological deficits, especially on movement and cognitive function impairment. Here, we reviewed the therapeutic mechanisms of acupuncture at the neural circuit level in movement and cognition disorders, summarizing the influence of acupuncture in the dopaminergic system, glutamatergic system, γ-amino butyric acid-ergic (GABAergic) system, serotonergic system, cholinergic system, and glial cells at the circuit and synaptic levels. These findings can provide targets for clinical treatment and perspectives for further studies.

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TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology

Cited by 10 publications

References 102 publications

Glucagon-like peptide 1 (GLP-1) receptor agonists in experimental Alzheimer’s disease models: a systematic review and meta-analysis of preclinical studies

Glucagon-like peptide 1 (GLP-1) receptor agonists in experimental Alzheimer’s disease models: a systematic review and meta-analysis of preclinical studies

Electroacupuncture Pretreatment Attenuates Learning Memory Impairment Induced by Repeated Propofol Exposure and Modulates Hippocampal Synaptic Plasticity in Rats

The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review

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