Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway

Lei, Min; Guo, Xiying; Yao, Yue; Shu, Ting; Ren, Zhanhong; Yang, Xiaosong; Ouyang, Changhan; Chen, Qingjie; Liu, Chao; Liu, Xiufen

doi:10.1016/j.exger.2023.112307

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…10 These interventions are implemented to optimize patient prognosis by enhancing healing efficacies and minimizing complications associated with diabetic wounds. 11,12 In recent years, with the progress of stem cell research, adipose-derived stem cells (ADSCs), characterized by accessibility, ease of preparation, and robust regulatory and reparative capabilities, have been proven to exert promoting effects in the repair of various tissues and organ injuries, including hepatic and renal damage and wound healing. [13][14][15][16] In this context, the exosomes released by ADSCs (ADSC-exos), serving as a form of intercellular communication, have attracted considerable attention for their robust cellular functional regulatory capabilities, endowing a novel therapeutic candidate for improving wound healing in diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adipose-Derived Stem Cell Exosomes Facilitate Diabetic Wound Healing: Mechanisms and Potential Applications

Wang,

Yang,

Zhang

et al. 2024

IJN

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adipose-Derived Stem Cell Exosomes Facilitate Diabetic Wound Healing: Mechanisms and Potential Applications

Wang,

Yang,

Zhang

et al. 2024

IJN

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Advancements and Challenges of Nanostructured Lipid Carriers for Wound Healing Applications

Wathoni,

Suhandi,

Elamin

et al. 2024

IJN

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The current treatments for wound healing still exhibit drawbacks due to limited availability at the action sites, susceptibility to degradation, and immediate drug release, all of which are detrimental in chronic conditions. Nano-modification strategies, offering various advantages that can enhance the physicochemical properties of drugs, have been employed in efforts to maximize the efficacy of wound healing medications. Nowadays, nanostructured lipid carriers (NLCs) provide drug delivery capabilities that can safeguard active compounds from environmental influences and enable controlled release profiles. Consequently, NLCs are considered an alternative therapy to address the challenges encountered in wound treatment. This review delves into the application of NLCs in drug delivery for wound healing, encompassing discussions on their composition, preparation methods, and their impact on treatment effectiveness. The modification of drugs into the NLC model can be facilitated using relatively straightforward technologies such as pressure-based processes, emulsification techniques, solvent utilization methods, or phase inversion. Moreover, NLC production with minimal material compositions can accommodate both single and combination drug delivery. Through in vitro, in vivo, and clinical studies, it has been substantiated that NLCs can enhance the therapeutic potential of various drug types in wound healing treatments. NLCs enhance efficacy by reducing the active substance particle size, increasing solubility and bioavailability, and prolonging drug release, ensuring sustained dosage at the wound site for chronic wounds. In summary, NLCs represent an effective nanocarrier system for optimizing the bioavailability of active pharmacological ingredients in the context of wound healing.

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Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway

Cited by 2 publications

References 34 publications

Adipose-Derived Stem Cell Exosomes Facilitate Diabetic Wound Healing: Mechanisms and Potential Applications

Adipose-Derived Stem Cell Exosomes Facilitate Diabetic Wound Healing: Mechanisms and Potential Applications

Advancements and Challenges of Nanostructured Lipid Carriers for Wound Healing Applications

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