Trelagliptin ameliorates oxygen–glucose deprivation/reperfusion (OGD/R)-induced mitochondrial dysfunction and metabolic disturbance of endothelial cells

Zhang, Yatong; Li, Chao; Pei, Yifang; Li, Zheng; Sun, Xiaogang; Zhao, Zinan; Wang, Shuanghu

doi:10.1007/s13577-021-00594-0

Cited by 4 publications

(10 citation statements)

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“…Consistent with previous research, increased RBM15 is also related to the development of tumors, such as colorectal cancer, laryngeal squamous cell cancer (LSCC) and pancreatic adenocarcinoma. It was reported that knocking down RBM15 inhibits colorectal cancer cell proliferation and metastasis as reported (Zhang Z. et al, 2021). Meanwhile, as a "writer" of methyltransferase, RBM15 was increased in LSCC, indicating an unfavorable prognosis; the decline of RBM15 reduced the proliferation, migration and invasion of LSCC cells (Wang et al, 2021).…”

Section: Discussionmentioning

confidence: 93%

“…Then, the m6A modification patterns were further validated using principal component analysis (PCA) (Fu et al, 2022). The single sample gene set enrichment analysis (ssGSEA), as a method to evaluate the number of distinct infiltrating immunocytes and their specific immune reactions, was then adapted to estimate the abundance of 23 immune cells between distinct m6A clusters to explore the correlation (Zhang et al, 2021).…”

Section: Discover Different M6a Clusters and Immune Microenvironment ...mentioning

confidence: 99%

“…Depending on the availability of nutrients, metabolic products modulate cell signaling and gene expression (Liberti, and Locasale, 2020). A large amount of lactate is produced by anaerobic glycolysis (Zhang et al, 2021), which is originally thought that it was a Warburg effect end product and a metabolic waste product by glycolysis. Nevertheless, lactate is now recognized as an energy source, a signaling molecule, and an immunoregulatory molecule (Bhagat et al, 2019).…”

Section: Glycolysis and Glucose Oxidation In Pahmentioning

confidence: 99%

“…The regulation of gene expression by lactate through histone lactylation modification is a newly discovered epigenetic modification, and a novel PTM has been identified in human and mouse core histones (Bhagat et al, 2019). Histone lactylation is involved in many cellular processes, including translation, metabolism, recombination, and repair (Zhang et al, 2021). Mechanically, lactate is used as a substrate to generate lactyl-CoA for lysine lactylation on histones, a process that regulates gene expression in a variety of pathophysiological conditions (Zhang et al, 2019).…”

Section: Glycolysis and Glucose Oxidation In Pahmentioning

confidence: 99%

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Epigenetic and Genetic Mechanisms Underlying Cardiovascular Diseases and Neurodevelopmental Disorders

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Discussionmentioning

confidence: 93%

Section: Discover Different M6a Clusters and Immune Microenvironment ...mentioning

confidence: 99%

Section: Glycolysis and Glucose Oxidation In Pahmentioning

confidence: 99%

Section: Glycolysis and Glucose Oxidation In Pahmentioning

confidence: 99%

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Epigenetic and Genetic Mechanisms Underlying Cardiovascular Diseases and Neurodevelopmental Disorders

2024

Frontiers Research Topics

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“…[24] Furthermore, animal studies also support the notion that post-AMI endogenous angiogenic responses can be boosted to reduce scarring and adverse left ventricular remodeling. [25] The combination of LAD ligation and the OGD model is commonly used in vivo and in vitro studies of AMI [17,24,[26][27][28] . As early as 2000, researchers used the OGD model to simulate oxidative stress in myocardial cells under ischemic and hypoxic conditions.…”

Section: Discussionmentioning

confidence: 99%

Role of DNA Methylation in Ischemic-Hypoxic Endothelial Cells and its Clinical Implications in AMI Patients

Tang,

Wang,

Wang

et al. 2023

Preprint

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The obstructed coronary artery undergoes a series of pathological changes due to ischemia and hypoxic shocks during acute myocardial infarction (AMI). However, the altered DNA methylation levels in endothelial cells under these conditions and their implication for the etiopathology of AMI have not been investigated in detail. This study aimed to explore the relationship between DNA methylation and pathologically altered gene expression profile in human umbilical vein endothelial cells (HUVECs) subjected to oxygen-glucose deprivation (OGD), and its clinical implications in AMI Patients. The Illumina Infinium MethylationEPIC BeadChip assay was used to explore the genome-wide DNA methylation profile using the Novaseq6000 platform for mRNA sequencing in 3 pairs of HUVEC-OGD and control samples. GO and KEGG pathway enrichment analyses, as well as correlation, causal inference test (CIT), and protein-protein interaction (PPI) analyses identified 22 hub genes that were validated by MethylTarget sequencing as well as qRT-PCR. ELISA was used to detect four target molecules associated with the progression of AMI. A total of 2524 differentially expressed genes (DEGs) and 22148 differentially methylated positions corresponding to 6642 differentially methylated genes were screened (|Δβ|>0.1 and detection p<0.05). After GO, KEGG, correlation, CIT, and PPI analyses, 441 genes were filtered. qRT-PCR confirmed the overexpression of VEGFA, CCL2, THBS1, SQSTM1, BCL2L11, and TIMP3 genes, and downregulation of MYC, CD44, BDNF, GNAQ, RUNX1, ETS1, NGFR, MME, SEMA6A, GNAI1, IFIT1, and MEIS1. DNA fragments BDNF_1_ (r=0.931, p<0.0001) and SQSTM1_2_NEW (r=0.758, p=0.0043) were positively correlated with the expressions of corresponding genes, and MYC_1_ (r=-0.8245, p=0.001) was negatively correlated. Furthermore, ELISA confirmed TNFSF10 and BDNF were elevated in the peripheral blood of AMI patients (p=0.0284 and p=0.0142, respectively). Combined sequencing from in-vitro cellular assays with clinical samples, focusing on the importance of endothelial cells in AMI, our study identified promising OGD-specific genes, which provided a solid basis for screening fundamental diagnostic and prognostic biomarkers of coronary endothelial cell injury of AMI. Moreover, it furnished the first evidence that during ischemia and hypoxia, the expression of BNDF was regulated by DNA methylation in endothelial cells and elevated in peripheral blood.

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Targeting mitochondrial quality control for diabetic cardiomyopathy: Therapeutic potential of hypoglycemic drugs

Zhou,

Suo,

Zhang

et al. 2023

Biomedicine & Pharmacotherapy

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Trelagliptin ameliorates oxygen–glucose deprivation/reperfusion (OGD/R)-induced mitochondrial dysfunction and metabolic disturbance of endothelial cells

Cited by 4 publications

References 36 publications

Epigenetic and Genetic Mechanisms Underlying Cardiovascular Diseases and Neurodevelopmental Disorders

Epigenetic and Genetic Mechanisms Underlying Cardiovascular Diseases and Neurodevelopmental Disorders

Role of DNA Methylation in Ischemic-Hypoxic Endothelial Cells and its Clinical Implications in AMI Patients

Targeting mitochondrial quality control for diabetic cardiomyopathy: Therapeutic potential of hypoglycemic drugs

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