Treinamento aeróbio de natação aumenta a atividade de enzimas antioxidantes e o conteúdo de glicogênio no musculoesquelético de ratos

Vieira, Roberto Carlos; Silva, Carolina Mendes Santos; Araújo, Michel Barbosa de; García, Adriana; Voltarelli, Vanessa Azevedo; Filho, Adilson Domingos dos Reis; Voltarelli, Fabrí­cio Azevedo

doi:10.1590/s1517-86922013000300012

Cited by 10 publications

(6 citation statements)

References 31 publications

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“…For example, SOD levels are commonly higher in the resting blood and muscle of trained individuals compared to those of control groups (Tiidus et al, 1996). Endurance training may increase the activities of SOD and GPx in both plasma and exercised muscles (Lambertucci et al, 2007; Brooks et al, 2008; Vieira Junior et al, 2013; Azizbeigi et al, 2014). This magnitude of exercise-mediated changes in SOD or GPx activities is dependent on the intensity and duration of that specific exercise.…”

Section: Ros-induced Adaptive Response To Exercisementioning

confidence: 99%

Redox Mechanism of Reactive Oxygen Species in Exercise

et al. 2016

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It is well known that regular exercise can benefit health by enhancing antioxidant defenses in the body. However, unaccustomed and/or exhaustive exercise can generate excessive reactive oxygen species (ROS), leading to oxidative stress-related tissue damages and impaired muscle contractility. ROS are produced in both aerobic and anaerobic exercise. Mitochondria, NADPH oxidases and xanthine oxidases have all been identified as potential contributors to ROS production, yet the exact redox mechanisms underlying exercise-induced oxidative stress remain elusive. Interestingly, moderate exposure to ROS is necessary to induce body's adaptive responses such as the activation of antioxidant defense mechanisms. Dietary antioxidant manipulation can also reduce ROS levels and muscle fatigue, as well as enhance exercise recovery. To elucidate the complex role of ROS in exercise, this review updates on new findings of ROS origins within skeletal muscles associated with various types of exercises such as endurance, sprint and mountain climbing. In addition, we will examine the corresponding antioxidant defense systems as well as dietary manipulation against damages caused by ROS.

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Section: Ros-induced Adaptive Response To Exercisementioning

confidence: 99%

Redox Mechanism of Reactive Oxygen Species in Exercise

et al. 2016

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“…12,13 The previous treatment of animals with carnosine showed a reduction in the activity of these enzymes in muscle homogenate, indicating an antioxidant action. Vieira Junior et al, 14 found differences in GPx enzyme activity between the two groups evaluated, with higher mean values in the group that had swimming training compared to the sedentary group. In another study, the authors only identified glutathione peroxidase activity difference at certain training intensities.…”

Section: Resultsmentioning

confidence: 95%

Carnosine Avoids the Oxidative Damage Caused by Intense Exercise on Rat Soleus Muscle

Bortolatto

Medeiros

Guelfi

et al. 2020

Rev Bras Med Esporte

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Introduction: Intense physical exercise affects the balance between the production of reactive oxygen species and antioxidant defense in the muscle. Carnosine is a cytoplasmic dipeptide composed of the amino acids β-alanine and histidine. Objective: This study aimed to evaluate the effect of carnosine and its precursor β-alanine on oxidative damage caused by intense physical exercise in the soleus muscle of rats. Methods: Male Wistar rats weighing between 200 and 240 g were divided into four groups: control, exercise, exercise + β-alanine and exercise + carnosine. The animals from the groups that underwent the exercise ran on a treadmill for 60 minutes at 25 m/minute. Factors related to muscle damage and oxidative stress were assessed in soleus muscle homogenate and blood serum. Results: The exercise promoted muscle damage, as observed through increased serum activity of enzymes aspartate aminotransferase and creatine kinase. It also induced oxidative stress in soleus muscle, as seen by the increased activity of the enzymes glutathione peroxidase and glutathione reductase, decreased concentration of reduced glutathione, and increased concentration of malondialdehyde, an indicator of lipid peroxidation. Carnosine kept the creatine kinase, glutathione peroxidase and glutathione reductase enzyme activity values, and the concentration of reduced glutathione and malondialdehyde, close to those of the control group. Conclusion: The results indicate that pretreatment with carnosine protected the rat soleus muscle against oxidative damage and consequent injury caused by intense physical exercise. Level of evidence II; Therapeutic studies-Investigating the treatment results.

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“…Penelitian lain yang terkait peningkatan kapasitas antioksidan akibat latihan olahraga juga dipaparkan (Vieira Junior et al, 2013) didapatkan hasil terjadinya peningkatan kapasitas antioksidan (SOD) sebesar 36,83%. Demikian juga penelitian (Azizbeigi et al, 2014), terdapatkan peningkatan kapasitas antioksidan akibat latihan olahraga, namun hasil yang didapatkan sangat bervariasi tergantung model latihannya.…”

Section: Pendahuluanunclassified

“…Hal yang senada dihasilkan (Poblete Aro et al, 2015) latihan kontinu intensitas sedang mampu meningkatkan kapasitas antioksidan. Juga senada dengan hasil penelitian yang dilakukan (Vieira Junior et al, 2013) menyatakan dengan latihan aerobik 5x/minggu, selama 8 minggu didapatkan hasil peningkatan aktvitas enzim antioksidan (superoxide dismutase, Catalase dan glutathione peroxidase), serta terjadi penurunan kadar MDA. Hasil penelitian (Ajabi, F. J., & Mohammad, 2013) menujukkan dengan latihan aerobik 3x/minggu selama 12 minggu terjadi peningkatan antioksidan SOD dan CAT, serta terjadi penurunan kadar MDA plasma darah.…”

Section: Pembahasanunclassified

Peningkatan Kapasitas Antioksidan Akibat Latihan Aerobik Intensitas Sedang

Yunus

Hapsari

Umar

2022

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Latihan aerobik intensitas sedang diindikasikan mampu meningkatkan kapasitas antioksidan dalam tubuh manusia, yang salah satunya ditandai dengan peningkatan SOD plasma. Penelitian ini bertujuan untuk mengkaji besarnya peningkatan kapasitas antioksidan akibat latihan aerobik intensitas sedang. Penelitian ini merupakan penelitian eksperimental semu dengan pendekatan kuantitatif dan rancangan one group pretest and posttest design. Populasi dalam penelitian ini adalah mahasiswa jurusan Pendidikan Kepelatihan Olahraga Univeristas Negeri Malang. Teknik sampling menggunakan purposive sampling, dengan jumlah sampel sebanyak 20 mahasiswa. Data dikumpulkan dengan mengukur aktivitas SOD plasma darah sebagai indikator kapasitas antioksidan. Pengukuran SOD dilakukan sebelum dan setelah perlakuan latihan aerobik intensitas sedang, dengan frekensi 3 kali perminggu, selama 8 minggu. Data kemudian dianalisis dengan uji-t berpasangan (α=0,05). Hasil penelitian didapatkanrata rata dan standar deviasi aktivitas SOD pretest 21,78±2,60 U/ml dan postest 32,03±1,42 U/ml, terdapat peningkatan rata-rata aktivitas SOD plasma sebesar 23,9% (p=0,023< 0,05). Simpulan penelitian ini terdapat peningkatan kapasitas antioksidan yang signifikan akibat latihan aerobik intensitas sedang

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Treinamento aeróbio de natação aumenta a atividade de enzimas antioxidantes e o conteúdo de glicogênio no musculoesquelético de ratos

Cited by 10 publications

References 31 publications

Redox Mechanism of Reactive Oxygen Species in Exercise

Redox Mechanism of Reactive Oxygen Species in Exercise

Carnosine Avoids the Oxidative Damage Caused by Intense Exercise on Rat Soleus Muscle

Peningkatan Kapasitas Antioksidan Akibat Latihan Aerobik Intensitas Sedang

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