Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance

Arai, Chikako; Arai, Norie; Mizote, Akiko; Kohno, Keizo; Iwaki, Kanso; Hanaya, Toshiharu; Arai, Shigeyuki; Ushio, Simpei; Fukuda, Shigeharu

doi:10.1016/j.nutres.2010.10.009

Cited by 56 publications

(49 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results were consistent with our previous observations that simultaneous administration of 2.5% trehalose with HFD inhibited adipocyte hypertrophy and mitigated insulin resistance (5). We therefore confirmed our hypothesis proposed in the introduction section and concluded that administration of trehalose, either before or after the development of obesity, prevents adi- Fig.…”

Section: Discussionsupporting

confidence: 93%

“…Trehalose has been shown to stimulate insulin secretion less potently than glucose in oral saccharide tolerance tests in humans (4). Given this hypoinsulinemic effect of trehalose, we have previously shown that simultaneous intake of trehalose and a high-fat diet (HFD) suppresses adipocyte hypertrophy and mitigates insulin resistance in mice (5). These effects were not elicited by glucose, maltose, high-fructose corn syrup (HFCS), or fructose.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Trehalose Prevents Adipocyte Hypertrophy and Mitigates Insulin Resistance in Mice with Established Obesity

Arai

Miyake

Matsumoto

et al. 2013

J Nutr Sci Vitaminol

Self Cite

View full text Add to dashboard Cite

Summary Our group recently demonstrated that simultaneous administration of trehalose with a high-fat diet (HFD) suppresses adipocyte hypertrophy and mitigates insulin resistance in mice. For the present study, we hypothesized that similar effects of trehalose would be observed in mice with previously-established obesity. Obese mice were fed a HFD and drinking water containing 0.3 or 2.5% (weight/volume) trehalose or distilled water (DW) ad libitum for 8 wk. After 7 wk intake of a HFD and trehalose, fasting serum insulin levels and homeostasis model assessment-insulin resistance (HOMA-IR) in the 0.3% Tre/ HFD group were significantly lower than those in the DW/HFD group (p,0.05). After 8 wk of treatment, mesenteric adipocytes in the 0.3% Tre/HFD group showed significantly less hypertrophy than those in the DW/HFD group. Mechanistic analysis indicated that levels of high molecular weight (HMW) adiponectin in the serum of the 0.3% Tre/HFD group were significantly higher than those in the DW/HFD group. The expression levels of insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) messenger RNA (mRNA) in muscle were also significantly increased by trehalose intake. Our data therefore suggest that administration of trehalose to obese mice mitigates insulin resistance by suppressing adipocyte hypertrophy and increasing serum HMW adiponectin, resulting in upregulation of IRS-1, and IRS-2 expression in muscle. These results further suggest that trehalose is a functional saccharide that may be used to prevent the progression of insulin resistance.

show abstract

Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Trehalose Prevents Adipocyte Hypertrophy and Mitigates Insulin Resistance in Mice with Established Obesity

Arai

Miyake

Matsumoto

et al. 2013

J Nutr Sci Vitaminol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Using a metabolic syndrome mouse model, we have previously shown that trehalose intake mitigates insulin resistance and decreases impaired glucose tolerance as assessed using OGTT, and these effects are attributed to the suppression of adipocyte hypertrophy (2,3). In this study, to assess the preventive effect of trehalose on the development of metabolic syndrome, we examined whether this disaccharide suppresses the progression of insulin resistance in humans.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, the main dietary sources of naturally occurring trehalose are mushrooms, baker's and brewer's yeast, and certain types of shrimp (1). Our previous studies on metabolic syndrome using a mouse model showed that trehalose intake in mice fed with a high-fat diet (HFD) suppressed mesenteric adipocyte hypertrophy and decreased impaired glucose tolerance in an oral glucose tolerance test (OGTT) (2). In the mice fed with HFD, we also found that trehalose intake mitigated insulin resistance, reduced mRNA expression of plasminogen activator inhibitor-1 (PAI-1) (2), and increased serum high molecular weight (HMW) adiponectin (3).…”

mentioning

confidence: 99%

Daily Intake of Trehalose Is Effective in the Prevention of Lifestyle-Related Diseases in Individuals with Risk Factors for Metabolic Syndrome

Mizote

Yamada

Yoshizane

et al. 2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

Self Cite

View full text Add to dashboard Cite

SummaryWe previously performed animal studies that suggested that trehalose potentially prevents the development of metabolic syndrome in humans. To evaluate this possibility, we examined whether trehalose suppressed the progression of insulin resistance in a placebo-controlled, double-blind trial in 34 subjects with a body mass index (BMI) $23. The subjects were divided into two groups and were assigned to ingest either 10 g/d of trehalose or sucrose with meals for 12 wk. During the study, body composition and blood biochemical parameters were measured at week 0, 8, and 12. These parameters were also measured 4 wk after the end of intake to confirm the washout of test substances. In the trehalose group, blood glucose concentrations after a 2-h oral glucose tolerance test significantly decreased following 12 wk of intake in comparison with baseline values (0 wk). When a stratified analysis was performed in the subjects whose percentage of truncal fat approached the high end of the normal range, the change in body weight, waist circumference, and systolic blood pressure were significantly lower in the trehalose group than in the sucrose group. Our data indicated that a daily intake of 10 g of trehalose improved glucose tolerance and progress to insulin resistance. Furthermore, these results suggested that trehalose can potentially reduce the development of metabolic syndrome and associated lifestyle-related diseases, such as type 2 diabetes.

show abstract

“…1) Although a variety of biological activities, including anti-tumor, 2) anti-obesity, 3) and bonestrengthening activities 4) have been reported, use of trehalose for medicine is limited because of its degradation by trehalase under physiological conditions. Recently, trehalose derivatives lentztrehalose A, B, and C were reported as natural products of a rare actinomycete, Lentzea sp.…”

mentioning

confidence: 99%

Synthesis and Determination of Absolute Configuration of Lentztrehalose A

Zhang

Wada

Amemiya

et al. 2015

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

The synthesis of lentztrehalose A, a naturally occurring trehalose derivative exhibiting various biological activities including autophagy-inducing activity, was achieved. The synthesis commenced with the selective protection of hydroxyl groups of commercially available trehalose, followed by the introduction of the side chain moiety by two methods: 1) prenylation and successive diastereoselective dihydroxylation; or 2) etherification by opening of the chiral epoxide. The present synthetic study clarified the unreported absolute configuration of the secondary alcohol part in the side chain portion.

show abstract

Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance

Cited by 56 publications

References 34 publications

Trehalose Prevents Adipocyte Hypertrophy and Mitigates Insulin Resistance in Mice with Established Obesity

Trehalose Prevents Adipocyte Hypertrophy and Mitigates Insulin Resistance in Mice with Established Obesity

Daily Intake of Trehalose Is Effective in the Prevention of Lifestyle-Related Diseases in Individuals with Risk Factors for Metabolic Syndrome

Synthesis and Determination of Absolute Configuration of Lentztrehalose A

Contact Info

Product

Resources

About