Trehalose can effectively protect sheep epididymis epithelial cells from oxidative stress

ZhaoJin, Luan; Fan, Xuetong; Zhao, Yongchao; Song, Hong-Jun; Du, Wei; Wang, Zhaochen; Zhang, Wenguang; Zhang, Jiaxin

doi:10.5194/aab-64-335-2021

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…It has been reported that the level of TAS in 1st week of postpartum in dairy cows decreases compared to the prenatal period, but increases in the following weeks, which is an advantage for fertility (Elshahawy 2017, Luan et al 2021). In the present study, it was determined that the offspring yield was high in goats with high TAS levels.…”

Section: Discussionmentioning

confidence: 99%

Effect of oxidative stress on the reproductive performance of Hair Goat

Dursun

2023

J Hellenic Vet Med Soc

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Small ruminants are the type of animals that make the most of unsuitable land and contribute significantly to the country's economy. In order to achieve maximum yield from these animals, it is necessary to optimize nutrition and minimize stress factors. One of the important consequences of management and nutrition has been demonstrated by scientists to be oxidative stress. Oxidative stress affect the normal functioning of many physiological systems. In this study, oxidative stress index (OSI), total oxidation level (TOS) and total antioxidant (TAS) levels were investigated in 20 male and 100 female hair goats during the breeding season (October) and out-of-season (May). Females between the ages of 2-6 years and male hair goats aged 2-4 years were used in the study. The correlation between TAS, TOS, and OSI and fertility was evaluated according to sex and season. TAS, TOS and OSI values in female hair goats in October and May were, respectively; 1.28, 1.34; 11.02, 7.13; 0.87, 0.53; in males 1.32, 1.44; 4.24, 8.84; 0.32, 0.63 μmol/L. As a result, it was concluded that as the TOS level increased, the yield of the offspring decreased, and the increase in the TAS level positively affected the yield of the offspring.

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Section: Discussionmentioning

confidence: 99%

Effect of oxidative stress on the reproductive performance of Hair Goat

Dursun

2023

J Hellenic Vet Med Soc

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“…In studies of oxidative stress in epididymal epididymal cells in goats, miR-542-3p mRNA can downregulate the expression of GPX5, thereby aggravating oxidative damage in epididymal epididymal cells (Yang et al, 2022). In the study of the protective effect of trehalose on oxidative stress damage in sheep epididymal epididymal cells, it was again found that the upregulation of GPX5 plays a key role (Luan et al, 2021). It can be seen that GPX5 is essential in regulating oxidative stress damage in the epididymis and protecting sperm maturation, which is of great significance in maintaining the reproductive ability of mammals.…”

Section: Gpx5mentioning

confidence: 99%

Research progress of glutathione peroxidase family (GPX) in redoxidation

et al. 2023

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Maintaining the balance of a cell’s redox function is key to determining cell fate. In the critical redox system of mammalian cells, glutathione peroxidase (GPX) is the most prominent family of proteins with a multifaceted function that affects almost all cellular processes. A total of eight members of the GPX family are currently found, namely GPX1-GPX8. They have long been used as antioxidant enzymes to play an important role in combating oxidative stress and maintaining redox balance. However, each member of the GPX family has a different mechanism of action and site of action in maintaining redox balance. GPX1-4 and GPX6 use selenocysteine as the active center to catalyze the reduction of H2O2 or organic hydroperoxides to water or corresponding alcohols, thereby reducing their toxicity and maintaining redox balance. In addition to reducing H2O2 and small molecule hydroperoxides, GPX4 is also capable of reducing complex lipid compounds. It is the only enzyme in the GPX family that directly reduces and destroys lipid hydroperoxides. The active sites of GPX5 and GPX7-GPX8 do not contain selenium cysteine (Secys), but instead, have cysteine residues (Cys) as their active sites. GPX5 is mainly expressed in epididymal tissue and plays a role in protecting sperm from oxidative stress. Both enzymes, GPX7 and GPX8, are located in the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins, and GPX8 also plays an important role in the regulation of Ca2+ in the endoplasmic reticulum. With an in-depth understanding of the role of the GPX family members in health and disease development, redox balance has become the functional core of GPX family, in order to further clarify the expression and regulatory mechanism of each member in the redox process, we reviewed GPX family members separately.

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