Trehalose Biosynthesis Gene
            <i>otsA</i>
            Protects against Stress in the Initial Infection Stage of
            <i>Burkholderia</i>
            -Bean Bug Symbiosis

Lee, Junbeom; Jeong, Bohyun; Bae, Ha Ram; Jang, Ho Hee; Kim, Jiyeun Kate

doi:10.1128/spectrum.03510-22

Microbiol Spectr

2023

DOI: 10.1128/spectrum.03510-22

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Trehalose Biosynthesis Gene otsA Protects against Stress in the Initial Infection Stage of Burkholderia -Bean Bug Symbiosis

Junbeom Lee

Bohyun Jeong

Ha Ram Bae

et al.

Abstract: Symbiotic bacteria have to overcome stressful conditions present in association with the host. In the Burkholderia -bean bug symbiosis, we speculated that a stress-resistant function of Burkholderia is important and that trehalose, known as a stress protectant, plays a role in the symbiotic association.

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Cited by 3 publications

References 47 publications

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Arabidopsis class II TPS controls root development and confers salt stress tolerance through enhanced hydrophobic barrier deposition

Vishal,

Krishnamurthy,

Kumar

2024

Plant Cell Rep

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Arabidopsis class II TPS controls root development and confers salt stress tolerance through enhanced hydrophobic barrier deposition

Vishal,

Krishnamurthy,

Kumar

2024

Plant Cell Rep

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Alteration of lipopolysaccharide O antigen leads to avirulence of gut-colonizing Serratia marcescens

Lee,

Kim,

Lee

et al. 2023

Front. Microbiol.

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The reason why the potent entomopathogen Serratia marcescens fails to kill insects through oral infection is unknown. To compare effects of septic injection and oral administration of S. marcescens, we used a model bean bug, Riptortus pedestris. Most R. pedestris insects survived oral infections, but not septic infections. Although the number of S. marcescens cells in hemolymph after oral infection, which were originated from gut-colonizing S. marcescens, was higher than the fatal number of cells used in septic injection, they did not kill host insects, suggesting a loss of virulence in gut-colonizing S. marcescens cells. When gut-colonizing S. marcescens cells were septically injected into insects, they failed to kill R. pedestris and survive in hemolymph. To understand the avirulence mechanisms in gut-colonizing bacteria, lipopolysaccharides of S. marcescens were analyzed and revealed that the O antigen was lost during gut colonization. Gut-colonizing S. marcescens cells were resistant to humoral immune responses but susceptible to cellular immune responses, easily succumbing to phagocytosis of hemocytes. When cellular immunity was suppressed, the gut-colonizing S. marcescens cells recovered their virulence and killed insects through septic injection. These results suggest that a key mechanism of avirulence in orally infected S. marcescens is the loss of the O antigen, resulting in susceptibility to host’s cellular immune responses.

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Intracellular Protective Functions and Therapeutical Potential of Trehalose

Kuczyńska-Wiśnik,

Stojowska-Swędrzyńska,

Laskowska

2024

Molecules

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Trehalose is a naturally occurring, non-reducing saccharide widely distributed in nature. Over the years, research on trehalose has revealed that this initially thought simple storage molecule is a multifunctional and multitasking compound protecting cells against various stress factors. This review presents data on the role of trehalose in maintaining cellular homeostasis under stress conditions and in the virulence of bacteria and fungi. Numerous studies have demonstrated that trehalose acts in the cell as an osmoprotectant, chemical chaperone, free radical scavenger, carbon source, virulence factor, and metabolic regulator. The increasingly researched medical and therapeutic applications of trehalose are also discussed.

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Trehalose Biosynthesis Gene otsA Protects against Stress in the Initial Infection Stage of Burkholderia -Bean Bug Symbiosis

Cited by 3 publications

References 47 publications

Arabidopsis class II TPS controls root development and confers salt stress tolerance through enhanced hydrophobic barrier deposition

Arabidopsis class II TPS controls root development and confers salt stress tolerance through enhanced hydrophobic barrier deposition

Alteration of lipopolysaccharide O antigen leads to avirulence of gut-colonizing Serratia marcescens

Intracellular Protective Functions and Therapeutical Potential of Trehalose

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