Treg regulation of the epithelial stem cell lineage

Cho, Inchul; Ali, Nasreen

doi:10.1016/j.regen.2020.100028

Cited by 15 publications

(11 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In support, the intestines are most frequently affected by the loss-of-function mutations of the FOXP3 gene in IPEX patients, highlighting the key role of Treg cells in the intestinal tolerance (118). Intestinal TR-Treg cells are heterogeneous and can be divided into the three subsets based on transcription factor expression: GATA3+Helios+, RORgt+, and RORgt-Helios-Treg cells (119). Wang et al reported that Treg cell-specific deletion of GATA3 results in a spontaneous inflammatory disorder (120).…”

Section: Treg Cells In the Intestinementioning

confidence: 99%

Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease

2022

View full text Add to dashboard Cite

Foxp3+ regulatory T (Treg) cells are a CD4 T cell subset with unique immune regulatory function that are indispensable in immunity and tolerance. Their indisputable importance has been investigated in numerous disease settings and experimental models. Despite the extensive efforts in determining the cellular and molecular mechanisms operating their functions, our understanding their biology especially in vivo remains limited. There is emerging evidence that Treg cells resident in the non-lymphoid tissues play a central role in regulating tissue homeostasis, inflammation, and repair. Furthermore, tissue-specific properties of those Treg cells that allow them to express tissue specific functions have been explored. In this review, we will discuss the potential mechanisms and key cellular/molecular factors responsible for the homeostasis and functions of tissue resident Treg cells under steady-state and inflammatory conditions.

show abstract

Section: Treg Cells In the Intestinementioning

confidence: 99%

Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease

2022

View full text Add to dashboard Cite

show abstract

“…Multiple studies have shown that Treg cells directly communicate with lung stem cells to promote the recovery of damaged lung epithelium by enhancing the proliferation and differentiation of lung epithelial cell progenitors (26,27). How Treg cells communicate with stem cells is an active area of investigation (28), and initial evidence suggests that Treg cells can alter stem-progenitor cell function through direct mechanisms (e.g., epidermal growth factor receptor ligand generation, discussed above) as well as indirect mechanisms. As an example of an indirect mechanism, during the recovery phase of ALI, alveolar type II epithelial cells exhibit a heightened response to IFN signaling when Treg cells are depleted (29).…”

Section: Acute Lung Injury As a Model System To Dissect Distinct Treg Cell Functionsmentioning

confidence: 99%

Toward a Paradigm to Distinguish Distinct Functions of FOXP3+ Regulatory T Cells

Weinberg

Singer

2021

ImmunoHorizons

View full text Add to dashboard Cite

FOXP3 + regulatory T (Treg) cells are a unique subset of CD4 + T cells that classically function as master regulators of immune homeostasis. Besides this canonical suppressive role, which is required to maintain self-tolerance, a growing body of literature has identified Treg cells as critical orchestrators of tissue protection during acute stress and as effector cells that drive repair following tissue injury. Despite substantial interest in these distinct roles, the field has struggled to disentangle Treg cell suppressive functions from those that promote tissue defense and repair. In this article, we will examine the literature in the context of specific physiologic settings, contrasting the suppressive function of Treg cells with their emerging roles in promoting tissue homeostasis and tissue repair. Further, we will discuss a new paradigm differentiating tissue defense from tissue repaira paradigm needed to translate Treg cell-based therapies to the clinic. ImmunoHorizons, 2021, 5: 944-952.

show abstract

“…Interestingly, many of the immune cells are found to be associated with the follicular epithelium. The number of different types of immune cells fluctuates during the hair cycle and is not only critical for skin’s barrier function, but may also actively communicate with HFSCs to maintain tissue homeostasis (Cho et al, 2020; Rahmani et al, 2020; Wang & Higgins, 2020). In the immune cell‐rich milieu of the skin, some immune cells are known to crosstalk with HFSCs.…”

Section: Introductionmentioning

confidence: 99%

“…In the immune cell‐rich milieu of the skin, some immune cells are known to crosstalk with HFSCs. Responsible for phagocytosis and the clearing of debris (Yanez et al, 2017), macrophages are a potent regulator of HFSC quiescence and wound‐induced hair regeneration (Castellana et al, 2014; Rahmani et al, 2018; Wang et al, 2019; Cho et al, 2020; Rahmani et al, 2020; Wang & Higgins, 2020). γδT cells that secret cytokines in early immune responses are shown to promote HFSC activations after wounding (Kloepper et al, 2013; Lee et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Another category of epidermal T cells, αβT cells, can modulate HFSC behaviors both in homeostasis and in response to injury (Ali et al, 2017; Mathur et al, 2019). Since the intense regulation from immune cells to the hair follicle is well summarized in very recent reviews (Cho et al, 2020; Rahmani et al, 2020; Wang & Higgins, 2020), we will not elaborate it further here.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis

Tumbar

2021

The EMBO Journal

View full text Add to dashboard Cite

Stem cells are the essential source of building blocks for tissue homeostasis and regeneration. Their behavior is dictated by both cell‐intrinsic cues and extrinsic cues from the microenvironment, known as the stem cell niche. Interestingly, recent work began to demonstrate that hair follicle stem cells (HFSCs) are not only passive recipients of signals from the surroundings, but also actively send out signals to modulate the organization and function of their own niches. Here, we discuss recent findings, and briefly refer to the old, on the interaction of HFSCs and their niches with the emphasis on the outwards signals from HFSCs toward their niches. We also highlight recent technology advancements that further promote our understanding of HFSC niches. Taken together, the HFSCs emerge as a skin‐organizing center rich in signaling output for niche remodeling during various stages of adult skin homeostasis. The intricate crosstalk between HFSCs and their niches adds important insight to skin biology that will inform clinical and bioengineering fields aiming to build complete and functional 3D organotypic cultures for skin replacement therapies.

show abstract

Treg regulation of the epithelial stem cell lineage

Cited by 15 publications

References 90 publications

Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease

Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease

Toward a Paradigm to Distinguish Distinct Functions of FOXP3+ Regulatory T Cells

Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis

Contact Info

Product

Resources

About