Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair

Mathur, Anubhav N.; Zirak, Bahar; Boothby, Ian C.; Tan, Madge; Cohen, Jarish N.; Mauro, Thea; Mehta, Pooja; Lowe, Margaret M.; Abbas, Abul K.; Ali, Nasreen; Rosenblum, Michael D.

doi:10.1016/j.immuni.2019.02.013

Cited by 96 publications

(81 citation statements)

References 56 publications

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“…Multiple resident stem cell populations within the skin layers can be involved in nonmelanoma and melanoma skin cancer development; however, each population located in distinct stem cell niches has different tumorigenic potential that can correlate with distinct tumor phenotypes. These distinctive tumorigenic capacities may be due to various reasons, including the differential intrinsic expression levels of certain molecules, innate lineage fate of each stem cell population, and the composition of the stem cell niche microenvironment (e.g., nerve tissues and neighboring immune cells) 11,[32][33][34][35] , which may have tumor promotive or inhibitory functions. Importantly, stem cell differentiation fate can be altered by various physiological and environmental stress factors that change the tumor microenvironment 7,36 .…”

Section: The Role Of Cox-2 In Stem Cell-originating Cutaneous Tumor Fmentioning

confidence: 99%

New insights into the functions of Cox-2 in skin and esophageal malignancies

2020

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Understanding the cellular and molecular mechanisms of tumor initiation and progression for each cancer type is central to making improvements in both prevention and therapy. Identifying the cancer cells of origin and the necessary and sufficient mechanisms of transformation and progression provide opportunities for improved specific clinical interventions. In the last few decades, advanced genetic manipulation techniques have facilitated rapid progress in defining the etiologies of cancers and their cells of origin. Recent studies driven by various groups have provided experimental evidence indicating the cellular origins for each type of skin and esophageal cancer and have identified underlying mechanisms that stem/progenitor cells use to initiate tumor development. Specifically, cyclooxygenase-2 (Cox-2) is associated with tumor initiation and progression in many cancer types. Recent studies provide data demonstrating the roles of Cox-2 in skin and esophageal malignancies, especially in squamous cell carcinomas (SCCs) occurring in both sites. Here, we review experimental evidence aiming to define the origins of skin and esophageal cancers and discuss how Cox-2 contributes to tumorigenesis and differentiation.

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Section: The Role Of Cox-2 In Stem Cell-originating Cutaneous Tumor Fmentioning

confidence: 99%

New insights into the functions of Cox-2 in skin and esophageal malignancies

2020

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“…As described previously (13,64), entire trunk skin was harvested, lightly defatted, and minced with scissors before resuspending in digestion media composed of 2 mg/ml collagenase XI (MilliporeSigma, catalog C9407), 0.5 mg/ml hyaluronidase (MilliporeSigma, catalog C9407), and 0.1 mg/ml DNase in RPMI with 1% HEPES, 1% penicillin/streptomycin (Gibco), and 10% fetal calf serum. The tissue was shaken at 220 rpm in an incubator (Excella E25, New Brunswick Scientific) at 37°C for 45 minutes.…”

Section: Mouse Skin Processingmentioning

confidence: 99%

“…Treg production of amphiregulin within skeletal muscle, lung, and brain facilitates normal tissue regeneration after injury (6)(7)(8), whereas adipose tissue Tregs are crucial in attenuating inflammatory processes in fat and maintaining insulin sensitivity (5,9). IgA selection is specifically regulated by a subset of Tregs in the colon (10), whereas skin Tregs facilitate full-thickness wound healing, epidermal repair, and regulate hair follicle cycling (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues

Lowe¹,

Boothby²,

Clancy³

et al. 2019

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“…103 Similarly, skin Tregs also facilitate repair of the injured epithelial barrier by suppression of IL-17A, CXCL5, and subsequent neutrophil accumulation. 104 In turn, Tregs promote hair follicle stem cell (HFSC) activation, driving epidermal-differentiation genes (such as filaggrin, keratin1) and restoration of the epidermal barrier. 104 Overall, skin Tregs promote cutaneous repair by facilitating early innate immunity.…”

Section: Skin Tregs Facilitate Wound Healing and Control Fibroblast Amentioning

confidence: 99%

“…104 In turn, Tregs promote hair follicle stem cell (HFSC) activation, driving epidermal-differentiation genes (such as filaggrin, keratin1) and restoration of the epidermal barrier. 104 Overall, skin Tregs promote cutaneous repair by facilitating early innate immunity.…”

Section: Skin Tregs Facilitate Wound Healing and Control Fibroblast Amentioning

confidence: 99%

Tissue regulatory T cells

Cho

Ali

2020

Immunology

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Summary Foxp3+ CD4+ regulatory T cells (Tregs) are an immune cell lineage endowed with immunosuppressive functionality in a wide array of contexts, including both anti‐pathogenic and anti‐self responses. In the past decades, our understanding of the functional diversity of circulating or lymphoid Tregs has grown exponentially. Only recently, the importance of Tregs residing within non‐lymphoid tissues, such as visceral adipose tissue, muscle, skin and intestine, has been recognized. Not only are Tregs critical for influencing the kinetics and strength of immune responses, but the regulation of non‐immune or parenchymal cells, also fall within the purview of tissue‐resident or infiltrating Tregs. This review focuses on providing a systematic and comprehensive comparison of the molecular maintenance, local adaptation and functional specializations of Treg populations operating within different tissues.

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Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair

Cited by 96 publications

References 56 publications

New insights into the functions of Cox-2 in skin and esophageal malignancies

New insights into the functions of Cox-2 in skin and esophageal malignancies

Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues

Tissue regulatory T cells

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