2019
DOI: 10.1016/j.immuni.2019.02.013
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Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair

Abstract: Highlights d Treg cells promote epidermal regeneration after injury d Treg cells control a CXCL5-IL-17 axis of inflammation during epidermal repair d Treg-cell control of CXCL5 and IL-17 diverts HFSC differentiation toward IFE cells d CXCL5 or IL-17 neutralization restores HFSC differentiation in Treg-depleted mice

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Cited by 104 publications
(101 citation statements)
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References 56 publications
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“…Multiple resident stem cell populations within the skin layers can be involved in nonmelanoma and melanoma skin cancer development; however, each population located in distinct stem cell niches has different tumorigenic potential that can correlate with distinct tumor phenotypes. These distinctive tumorigenic capacities may be due to various reasons, including the differential intrinsic expression levels of certain molecules, innate lineage fate of each stem cell population, and the composition of the stem cell niche microenvironment (e.g., nerve tissues and neighboring immune cells) 11,[32][33][34][35] , which may have tumor promotive or inhibitory functions. Importantly, stem cell differentiation fate can be altered by various physiological and environmental stress factors that change the tumor microenvironment 7,36 .…”
Section: The Role Of Cox-2 In Stem Cell-originating Cutaneous Tumor Fmentioning
confidence: 99%
“…Multiple resident stem cell populations within the skin layers can be involved in nonmelanoma and melanoma skin cancer development; however, each population located in distinct stem cell niches has different tumorigenic potential that can correlate with distinct tumor phenotypes. These distinctive tumorigenic capacities may be due to various reasons, including the differential intrinsic expression levels of certain molecules, innate lineage fate of each stem cell population, and the composition of the stem cell niche microenvironment (e.g., nerve tissues and neighboring immune cells) 11,[32][33][34][35] , which may have tumor promotive or inhibitory functions. Importantly, stem cell differentiation fate can be altered by various physiological and environmental stress factors that change the tumor microenvironment 7,36 .…”
Section: The Role Of Cox-2 In Stem Cell-originating Cutaneous Tumor Fmentioning
confidence: 99%
“…As described previously (13,64), entire trunk skin was harvested, lightly defatted, and minced with scissors before resuspending in digestion media composed of 2 mg/ml collagenase XI (MilliporeSigma, catalog C9407), 0.5 mg/ml hyaluronidase (MilliporeSigma, catalog C9407), and 0.1 mg/ml DNase in RPMI with 1% HEPES, 1% penicillin/streptomycin (Gibco), and 10% fetal calf serum. The tissue was shaken at 220 rpm in an incubator (Excella E25, New Brunswick Scientific) at 37°C for 45 minutes.…”
Section: Mouse Skin Processingmentioning
confidence: 99%
“…Treg production of amphiregulin within skeletal muscle, lung, and brain facilitates normal tissue regeneration after injury (6)(7)(8), whereas adipose tissue Tregs are crucial in attenuating inflammatory processes in fat and maintaining insulin sensitivity (5,9). IgA selection is specifically regulated by a subset of Tregs in the colon (10), whereas skin Tregs facilitate full-thickness wound healing, epidermal repair, and regulate hair follicle cycling (11)(12)(13).…”
Section: Introductionmentioning
confidence: 99%
“…103 Similarly, skin Tregs also facilitate repair of the injured epithelial barrier by suppression of IL-17A, CXCL5, and subsequent neutrophil accumulation. 104 In turn, Tregs promote hair follicle stem cell (HFSC) activation, driving epidermal-differentiation genes (such as filaggrin, keratin1) and restoration of the epidermal barrier. 104 Overall, skin Tregs promote cutaneous repair by facilitating early innate immunity.…”
Section: Skin Tregs Facilitate Wound Healing and Control Fibroblast Amentioning
confidence: 99%
“…104 In turn, Tregs promote hair follicle stem cell (HFSC) activation, driving epidermal-differentiation genes (such as filaggrin, keratin1) and restoration of the epidermal barrier. 104 Overall, skin Tregs promote cutaneous repair by facilitating early innate immunity.…”
Section: Skin Tregs Facilitate Wound Healing and Control Fibroblast Amentioning
confidence: 99%