Trefoil factor family 3 (TFF3) expression and its interaction with estrogen receptor (ER) in endometrial adenocarcinoma

Mhawech‐Fauceglia, Paulette; Wang, Dan; Samrao, Damanzoopinder; Liu, Song; duPont, Nefertiti C.; Pejović, Tanja

doi:10.1016/j.ygyno.2013.03.030

Cited by 28 publications

(27 citation statements)

References 27 publications

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“…Administration of E 2 markedly increased the expression of the ER target genes TFF1, TFF2, TFF3 and PR in the uterus, consistent with previous studies (Dunbier et al, 2010;Ing and Tornesi, 1997;Mhawech-Fauceglia et al, 2013;Prest et al, 2002). However, PFOA administration had no influence on the expression of mRNA encoding these uterine ER target genes as compared to controls.…”

Section: Discussionsupporting

confidence: 90%

Comparative in vivo and in vitro analysis of possible estrogenic effects of perfluorooctanoic acid

Yao¹,

Ehresman²,

Rae³

et al. 2014

Toxicology

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Section: Discussionsupporting

confidence: 90%

Comparative in vivo and in vitro analysis of possible estrogenic effects of perfluorooctanoic acid

Yao¹,

Ehresman²,

Rae³

et al. 2014

Toxicology

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“…The current clinical dogma for endometrial cancer is that younger patients with endometrioid-type carcinomas are more likely obese with hormone-driven tumors that are low grade and low stage at the time of diagnosis and thus have a better prognosis [14]. Our results clearly show that this group of patients is heterogeneous at the molecular and clinical level.…”

Section: Clinical Insights and Implicationsmentioning

confidence: 66%

Identifying aggressive forms of endometrioid-type endometrial cancer: new insights into molecular subtyping

Liu

Broaddus

Zhang

2014

Expert Review of Anticancer Therapy

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“…The very rare, intergenic CNV-region on chromosome 1 includes three deletions and one duplication, which, if the duplication is considered to have a deleterious effect is very strongly associated (P = 1.24×10 −4 ). Among the genes affected by the very rare CNVs are FOXO3 , which recently has been shown to be differentially methylated and differentially expressed in a comparison between normal endometrial and endometriotic stromal cells [24], and TFF3, which is an estrogen-responsive gene shown to be up-regulated in endometrioid adenocarcinomas [25].…”

Section: Resultsmentioning

confidence: 99%

Endometriosis Is Associated with Rare Copy Number Variants

2014

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Endometriosis is a complex gynecological condition that affects 6–10% of women in their reproductive years and is defined by the presence of endometrial glands and stroma outside the uterus. Twin, family, and genome-wide association (GWA) studies have confirmed a genetic role, yet only a small part of the genetic risk can be explained by SNP variation. Copy number variants (CNVs) account for a greater portion of human genetic variation than SNPs and include more recent mutations of large effect. CNVs, likely to be prominent in conditions with decreased reproductive fitness, have not previously been examined as a genetic contributor to endometriosis. Here we employ a high-density genotyping microarray in a genome-wide survey of CNVs in a case-control population that includes 2,126 surgically confirmed endometriosis cases and 17,974 population controls of European ancestry. We apply stringent quality filters to reduce the false positive rate common to many CNV-detection algorithms from 77.7% to 7.3% without noticeable reduction in the true positive rate. We detected no differences in the CNV landscape between cases and controls on the global level which showed an average of 1.92 CNVs per individual with an average size of 142.3 kb. On the local level we identify 22 CNV-regions at the nominal significance threshold (P<0.05), which is greater than the 8.15 CNV-regions expected based on permutation analysis (P<0.001). Three CNV's passed a genome-wide P-value threshold of 9.3×10−4; a deletion at SGCZ on 8p22 (P = 7.3×10−4, OR = 8.5, Cl = 2.3–31.7), a deletion in MALRD1 on 10p12.31 (P = 5.6×10−4, OR = 14.1, Cl = 2.7–90.9), and a deletion at 11q14.1 (P = 5.7×10−4, OR = 33.8, Cl = 3.3–1651). Two SNPs within the 22 CNVRs show significant genotypic association with endometriosis after adjusting for multiple testing; rs758316 in DPP6 on 7q36.2 (P = 0.0045) and rs4837864 in ASTN2 on 9q33.1 (P = 0.0002). Together, the CNV-loci are detected in 6.9% of affected women compared to 2.1% in the general population.

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Trefoil factor family 3 (TFF3) expression and its interaction with estrogen receptor (ER) in endometrial adenocarcinoma

Cited by 28 publications

References 27 publications

Comparative in vivo and in vitro analysis of possible estrogenic effects of perfluorooctanoic acid

Comparative in vivo and in vitro analysis of possible estrogenic effects of perfluorooctanoic acid

Identifying aggressive forms of endometrioid-type endometrial cancer: new insights into molecular subtyping

Endometriosis Is Associated with Rare Copy Number Variants

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