Treatments for alopecia areata: a network meta-analysis

Novoa-Candia, Monica; Sánchez-Vanegas, Guillermo; Arévalo-Rodríguez, Ingrid; Vañó‐Galván, Sergio; Rodriguez, Mayra; Giraldo, Lucía; Saceda‐Corralo, David; Tobías, Aurelio; Tomlinson, J.; ­Ortega‐Quijano, ­Daniel; Zamora, Javier

doi:10.1002/14651858.cd013719

Cited by 3 publications

(4 citation statements)

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“…14,15 The excimer laser is suggested to prompt T-cells apoptosis and cutaneous immunomodulation, making it a potential and promising method for the management of AA. [16][17][18] To date, most clinical trials have compared the effectiveness of excimer radiation with untreated controls. 12,[19][20][21][22] Herein, we embarked on this randomized, investigator-blind controlled trial to compare the therapeutic effects of the excimer laser with intralesional corticosteroids (ILCS) in patients with AA.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the efficacy and safety of 308‐nm excimer laser with intralesional corticosteroids for the treatment of alopecia areata: A randomized controlled study

et al. 2021

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Background: Corticosteroids have been the mainstay of treatment for alopecia areata (AA). Recently, the 308-nm excimer laser has been proposed for treating AA. Objectives: To compare the efficacy and safety of excimer laser with intralesional corticosteroid (ILCS) in AA. Methods: Patients with at least two alopecic patches were randomly assigned to receive weekly excimer laser treatments or monthly injections of ILCS. Photographs and trichoscopy images were examined at baseline, the last treatment session, and after one month of follow-up. The hair regrowth score was evaluated on a 6-point scale.Results: Sixteen patients with 99 alopecic patches completed the study. At the last treatment session, the mean score of hair regrowth for the laser was significantly lower than the ILCS (p = 0.003). However, after a month of follow-up, the difference was not statistically significant (p = 0.148). Positive response in hair regrowth (≥50%) was achieved in 47% of laser-treated patches and 66% in ILCStreated ones. Four (25%) and 8 (50%) patients experienced severe adverse events of laser and ILCS, respectively. Conclusions: The excimer laser was safe and effective in AA. The effect of laser on hair regrowth might be delayed as compared with ILCS.

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Section: Introductionmentioning

confidence: 99%

“…Its beneficial effect on psoriasis and vitiligo by immunomodulatory route has been well discussed 14,15 . The excimer laser is suggested to prompt T‐cells apoptosis and cutaneous immunomodulation, making it a potential and promising method for the management of AA 16–18 …”

Section: Introductionmentioning

confidence: 99%

Comparison of the efficacy and safety of 308‐nm excimer laser with intralesional corticosteroids for the treatment of alopecia areata: A randomized controlled study

et al. 2021

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“…This frustration has been rooted for the past decades by the absence of effective systemic treatments. 1 However, times are changing, and recent advances in understanding the immune mechanisms of the disease have led to the development and approval of new systemic treatments, revolutionizing the approach to managing AA. 2 While not life-threatening, the disease significantly impacts the quality of life and is often underestimated.…”

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confidence: 99%

“…Over the decades, managing severe alopecia areata (AA) has proven to be frustrating for most dermatologists and patients. This frustration has been rooted for the past decades by the absence of effective systemic treatments 1 . However, times are changing, and recent advances in understanding the immune mechanisms of the disease have led to the development and approval of new systemic treatments, revolutionizing the approach to managing AA 2…”

mentioning

confidence: 99%