Treatment with some anti-inflammatory drugs reduces germ tube formation in Candida albicans strains

Rusu, Elena; Radu-Popescu, Manuela; Pelinescu, Diana; Vassu, Tatiana

doi:10.1590/s1517-83822014000400031

Cited by 29 publications

(23 citation statements)

References 14 publications

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“…Notably, recent studies have suggested that COX inhibitors had strong antifungal activity against C. albicans by a PGE 2 -dependent mechanism. It can inhibit fungal prostaglandin synthesis and therefore reduce biofilm development in C. albicans (Alem and Douglas, 2004, 2005; Ghalehnoo et al, 2010; Bink et al, 2012; Rusu et al, 2014). They inhibit the growth of C. albicans in a dose-dependent manner (de Quadros et al, 2011).…”

Section: Cyclooxygenasementioning

confidence: 99%

Potential Antifungal Targets against a Candida Biofilm Based on an Enzyme in the Arachidonic Acid Cascade—A Review

Liu

Wang

et al. 2016

Front. Microbiol.

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Candida is an important opportunistic fungal pathogen, especially in biofilm associated infections. The formation of a Candida biofilm can decrease Candida sensitivity to antifungal drugs and cause drug resistance. Although many effective antifungal drugs are available, their applications are limited due to their high toxicity and cost. Seeking new antifungal agents that are effective against biofilm-associated infection is an urgent need. Many research efforts are underway, and some progress has been made in this field. It has been shown that the arachidonic acid cascade plays an important role in fungal morphogenesis and pathogenicity. Notably, prostaglandin E2 (PGE2) can promote the formation of a Candida biofilm. Recently, the inhibition of PGE2 has received much attention. Studies have shown that cyclooxygenase (COX) inhibitors, such as aspirin, ibuprofen, and indomethacin, combined with fluconazole can significantly reduce Candida adhesion and biofilm development and increase fluconazole susceptibility; the MIC of fluconazole can be decrease from 64 to 2 μg/ml when used in combination with ibuprofen. In addition, in vivo studies have also confirmed the antifungal activities of these inhibitors. In this article, we mainly review the relationship between PGE2 and Candida biofilm, summarize the antifungal activities of COX inhibitors and analyze the possible antifungal activity of microsomal prostaglandin E synthase-1 (MPGES-1) inhibitors; additionally, other factors that influence PGE2 production are also discussed. Hopefully this review can disclose potential antifungal targets based on the arachidonic acid cascade and provide a prevailing strategy to alleviate Candida albicans biofilm formation.

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Section: Cyclooxygenasementioning

confidence: 99%

Potential Antifungal Targets against a Candida Biofilm Based on an Enzyme in the Arachidonic Acid Cascade—A Review

Liu

Wang

et al. 2016

Front. Microbiol.

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“…Previous research on the effect of anti-inflamatory drugs (aspirin, diclofenac) showed the inhibitory effect of these chemicals on cell viability and morphology of some Candida albicans strains [14,15] and also diclofenac was able to induce direct mitochondrial dysfunction [16,17].…”

Section: Resultsmentioning

confidence: 99%

Ultrastructural Changes of Candida albicans Species Induced by the Presence of Sodium Diclofenac

Rusu¹,

Sarbu²,

Mitache³

et al. 2017

Rev. Chim.

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The high frequency of occurrence of candidiasis as well as high mortality of patients with immunosuppression cause a tendency toward better understanding of Candida albicans species virulence factors and developing sensitive and specific diagnostic methods, and appropriate strategies of candidiasis treatment. In recent decades the incidence of fungal infections has alarming increases because of advanced medical treatments. In this study was analyzed possible ultrastructural changes of the species C. albicans cells following treatment with sodium diclofenac at various concentrations. Following treatment of C. albicans cells with sodium diclofenac 1 mM and 2 mM changes in the plasmalemma can be noticed, changes in the density of cell wall, disruption and necrotic appearance of the cytoplasm.

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“…It has been reported that Candida albicans use arachidonic acid released during infection as the sole source of carbon and utilize prostaglandin E2 derived from arachidonic acid for its germ tube development. 15,16 The development of PGE2 involves COX The crude extract and all the fractions recorded no activity; DMSO = Dimethyl sulphoxide. enzymes.…”

Section: Discussionmentioning

confidence: 99%

The Anti-inflammatory Property of Mitracarpus villosus (Sw.) DC. Extract is Responsible for its use in the Treatment of Ring Worm Infection

et al. 2018

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Background:Microbial pathogens continuously mutate in order to survive the activities of new antimicrobials. This is the reason new antimicrobials are easily rendered useless after introduction. Continuous search for new antimicrobial agents is therefore an imperative until a permanent solution is found. Natural products have contributed immensely to the development of new drugs. The extract of Mitracarpus villosus (Sw.) DC., family: Rubiaceae, which is used traditionally for topical treatment of eczema and ring worm infections is a potential source of new antimicrobial compounds. Method: The methanol-methyl chloride extracts of the whole plant and leaves were partitioned into n-hexane, ethyl acetate, n-butanol and aqueous fractions. Both the crude and fractions were tested for antifungal and anti-inflammatory properties. The cytotoxicity property of the leaf extract was also investigated. Results: Results showed that the whole plant extract had no bioactivity. The aqueous fraction also showed no activity while the n-butanol fraction showed considerable anti-inflammatory activity. There was no antifungal activity in both crude and fractions. The leaf extract and fractions also showed no antifungal properties but exhibited strong anti-inflammatory properties. M. villosus is used mainly for the treatment of ring worm which is a fungal infection. Conclusion: Based on the absence of in vitro antifungal properties in the entire specimen tested, we propose that the effectiveness of the herb as an anti-fungal agent is derived from its antiinflammatory property.

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Treatment with some anti-inflammatory drugs reduces germ tube formation in Candida albicans strains

Cited by 29 publications

References 14 publications

Potential Antifungal Targets against a Candida Biofilm Based on an Enzyme in the Arachidonic Acid Cascade—A Review

Potential Antifungal Targets against a Candida Biofilm Based on an Enzyme in the Arachidonic Acid Cascade—A Review

Ultrastructural Changes of Candida albicans Species Induced by the Presence of Sodium Diclofenac

The Anti-inflammatory Property of Mitracarpus villosus (Sw.) DC. Extract is Responsible for its use in the Treatment of Ring Worm Infection

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