Treatment with Luteolin Improves Lipopolysaccharide-Induced Periodontal Diseases in Rats

Casili, Giovanna; Ardizzone, Alessio; Lanza, Marika; Gugliandolo, Enrico; Portelli, Marco; Militi, Angela; Cuzzocrea, Salvatore; Esposito, Emanuela; Paterniti, Irene

doi:10.3390/biomedicines8100442

Cited by 25 publications

(21 citation statements)

References 47 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This last type can induce or amplify the immune response [ 99 ]. Among the various forms of cancer, brain tumors can certainly be classified as the most lethal and widespread [ 100 ]. Currently, conventional therapy includes chemotherapy, radiotherapy, and surgical practice [ 100 ].…”

Section: Immunotherapy In Brain Tumors By Cytokines Modulationmentioning

confidence: 99%

“…Among the various forms of cancer, brain tumors can certainly be classified as the most lethal and widespread [ 100 ]. Currently, conventional therapy includes chemotherapy, radiotherapy, and surgical practice [ 100 ]. Therefore, considering the high mortality and the absence of an effective and resolutive therapy, the discovery of new therapeutic strategies for brain tumors would certainly represent an important goal for research.…”

Section: Immunotherapy In Brain Tumors By Cytokines Modulationmentioning

confidence: 99%

See 1 more Smart Citation

Immunomodulatory Effect of Microglia-Released Cytokines in Gliomas

et al. 2021

Self Cite

View full text Add to dashboard Cite

Microglia, a type of differentiated tissue macrophage, are considered to be the most plastic cell population of the central nervous system (CNS). Microglia substantially contribute to the growth and invasion of tumor mass in brain tumors including glioblastoma (GB). In response to pathological conditions, resting microglia undergo a stereotypic activation process and become capable of phagocytosis, antigen presentation, and lymphocyte activation. Considering their immune effector function, it is not surprising to see microglia accumulation in almost every CNS disease process, including malignant brain tumors. Large numbers of glioma associated microglia and macrophages (GAMs) can accumulate within the tumor where they appear to have an important role in prognosis. GAMs constitute the largest portion of tumor infiltrating cells, contributing up to 30% of the entire glioma mass and upon interaction with neoplastic cells. GAMs acquire a unique phenotype of activation, including both M1 and M2 specific markers. It has been demonstrated that microglia possess a dual role: on one hand, microglia may represent a CNS anti-tumor response, which is inactivated by local secretion of immunosuppressive factors by glioma cells. On the other hand, taking into account that microglia are capable of secreting a variety of immunomodulatory cytokines, it is possible that they are attracted by gliomas to promote tumor growth. A better understanding of microglia-glioma interaction will be helpful in designing novel immune-based therapies against these fatal tumors. Concluding, as microglia significantly may contribute to glioma biology, favoring tumor growth and invasiveness, these cells represent a valuable alternative/additional target for the development of more effective treatments for gliomas.

show abstract

Section: Immunotherapy In Brain Tumors By Cytokines Modulationmentioning

confidence: 99%

Section: Immunotherapy In Brain Tumors By Cytokines Modulationmentioning

confidence: 99%

Immunomodulatory Effect of Microglia-Released Cytokines in Gliomas

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…TNF-α and IL-1β levels were evaluated in the supernatants of the rats of each experimental group, as previously performed and described by Casili. et al [ 29 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory Pain

Ardizzone

Fusco

Casili

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Palmitoylethanolamide (PEA), a fatty acid amide, has been widely investigated for its analgesic and anti-inflammatory properties. The ultra-micronized formulation of PEA (um-PEA), that has an enhanced rate of dissolution, is extensively used. Acetyl-l-carnitine (LAC), employed for the treatment of neuropathic pain in humans, is able to cause analgesia by up-regulating type-2 metabotropic glutamate (mGlu2) receptors. In the present study, we tested different associations of um-PEA, LAC and non-micronized PEA (non-m-PEA) in a rat model of carrageenan (CAR)-induced paw edema. Intraplantar injection of CAR into the hind paw of animals caused edema, thermal hyperalgesia, accumulation of infiltrating inflammatory cells and augmented myeloperoxidase (MPO) activity. All these parameters were decreased in a significantly manner by oral administration of a compound constituted by a mixture of um-PEA and LAC in relation 1:1 (5 mg/kg), but not with the association of single compounds administered one after the other. These findings showed the superior anti-inflammatory and anti-nociceptive action displayed by oral administration of um-PEA and LAC versus LAC plus, separate but consecutive, um-PEA in the rat paw CAR model of inflammatory pain.

show abstract

“…4.10. ELISA Kit for TNF-α ELISA assay was performed as previously described by Casili et al [63]. Lumbar spinal cord tissues were homogenized with lysis buffer (Pierce #87787, Thermo Fisher Scientific, Waltham, MA, USA) and then supplemented with a protease inhibitor cocktail (Sigma-Aldrich, Rehovot, Israel).…”

Section: Drg Dissectionmentioning

confidence: 99%

PEA-OXA Mitigates Oxaliplatin-Induced Painful Neuropathy through NF-κB/Nrf-2 Axis

Campolo

Lanza

Paterniti

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several antineoplastics, such as oxaliplatin (L-OHP). The aim of the present work was to evaluate the potential beneficial effects of 2-pentadecyl-2-oxazoline (PEA-OXA) in a murine model of oxaliplatin-induced peripheral neuropathy (OIPN). OIPN was induced by an intraperitoneally injection of L-OHP in rats on five consecutive days (D0–4) for a final cumulative dose of 10 mg/kg. PEA-OXA and ultramicronized palmitoylethanolamide (PEAum), both 10 mg/kg, were given orally 15–20 min prior (L-OHP) and sacrifice was made on day 25. Our results demonstrated that PEA-OXA, more than PEAum, reduced the development of hypersensitivity in rats; this was associated with the reduction in hyperactivation of glia cells and the increased production of proinflammatory cytokines in the dorsal horn of the spinal cord, accompanied by an upregulation of neurotrophic factors in the dorsal root ganglia (DRG). Moreover, we showed that PEA-OXA reduced L-OHP damage via a reduction in NF-κB pathway activation and a modulation of Nrf-2 pathways. Our findings identify PEA-OXA as a therapeutic target in chemotherapy-induced painful neuropathy, through the biomolecular signaling NF-κB/Nrf-2 axis, thanks to its abilities to counteract L-OHP damage. Therefore, we can consider PEA-OXA as a promising adjunct to chemotherapy to reduce chronic pain in patients.

show abstract

Treatment with Luteolin Improves Lipopolysaccharide-Induced Periodontal Diseases in Rats

Cited by 25 publications

References 47 publications

Immunomodulatory Effect of Microglia-Released Cytokines in Gliomas

Immunomodulatory Effect of Microglia-Released Cytokines in Gliomas

Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory Pain

PEA-OXA Mitigates Oxaliplatin-Induced Painful Neuropathy through NF-κB/Nrf-2 Axis

Contact Info

Product

Resources

About