Treatment with IFN-α in corticosteroid-unresponsive asthma

Gratzl, Stephanie; Palca, Astrid; Schmitz, M. Lienhard; Simon, Hans‐Uwe

doi:10.1067/mai.2000.105317

Cited by 42 publications

(38 citation statements)

References 5 publications

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“…Interestingly, allergen immunotherapy increases IFN-c production by circulating T-lymphocytes in patients with clinical benefit [56] and increased numbers of IFN-c-expressing cells in nasal biopsy samples from patients with allergic rhinitis [57]. A preliminary report suggests that IFN-a may be useful in the treatment of patients with severe asthma who have reduced responsiveness to corticosteroids [58].…”

Section: Interferonsmentioning

confidence: 99%

Cytokine modulators as novel therapies for airway disease

Barnes¹

2001

European Respiratory Journal

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Cytokine modulators as novel therapies for airway disease. P.J. Barnes. #ERS Journals Ltd 2001. ABSTRACT: Cytokines play a critical role in orchestrating and perpetuating inflammation in asthma and chronic obstructive pulmonary disease (COPD), and several specific cytokine and chemokine inhibitors are now in development for the future therapy of these diseases.Anti-interleukin (IL)-5 is very effective at reducing peripheral blood and airway eosinophil numbers, but does not appear to be effective against symptomatic asthma. Inhibition of IL-4 with soluble IL-4 receptors has shown promising early results in asthma. Inhibitory cytokines, such as IL-10, interferons and IL-12 are less promising, as systemic delivery causes side-effects. Inhibition of tumour necrosis factor-a may be useful in severe asthma and for treating severe COPD with systemic features.Many chemokines are involved in the inflammatory response of asthma and COPD and several low-molecular-weight inhibitors of chemokine receptors are in development. CCR3 antagonists (which block eosinophil chemotaxis) and CXCR2 antagonists (which block neutrophil and monocyte chemotaxis) are in clinical development for the treatment of asthma and COPD respectively.Because so many cytokines are involved in asthma, drugs that inhibit the synthesis of multiple cytokines may prove to be more useful; several such classes of drug are now in clinical development and any risk of side-effects with these nonspecific inhibitors may be reduced by the use of inhalational route of delivery.

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Section: Interferonsmentioning

confidence: 99%

Cytokine modulators as novel therapies for airway disease

Barnes¹

2001

European Respiratory Journal

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“…Treatment with interferon-a improved lung function and also increased corticosteroid sensitivity in patients with corticosteroid-resistant asthma [154,155]. A defect in corticosteroid-induced synthesis by T-lymphocytes of the anti-inflammatory cytokine IL-10 has been implicated in corticosteroid-resistant asthma [119], and an IL-10 agonist might be a future therapy for this group of patients.…”

Section: Potential Drugs To Treat Smokers With Asthmamentioning

confidence: 99%

Asthma and cigarette smoking

Thomson

Chaudhuri²,

Livingston³

2004

European Respiratory Journal

469

269

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In most developed countries y25% of adults with asthma are current cigarette smokers. Asthma and active cigarette smoking interact to cause more severe symptoms, accelerated decline in lung function, and impaired short-term therapeutic response to corticosteroids.Cigarette smoking may modify inflammation that is associated with asthma, although there is limited published data on airway pathology in smokers with asthma. To date, the evidence points towards a combination of both heightened and suppressed inflammatory responses in smokers compared with nonsmokers with asthma.The mechanisms of corticosteroid resistance in asthmatic smokers are unexplained, but could be as a result of alterations in airway inflammatory cell phenotypes (e.g. increased neutrophils or reduced eosinophils), changes in the glucocorticoid receptor-a to -b ratio (e.g. overexpression of glucocorticoid receptor b), and increased activation of pro-inflammatory transcription factors (e.g. nuclear factor-kB) or reduced histone deacetylase activity.In conclusion, every effort should be made to encourage asthmatics who smoke to stop, although the effects of smoking cessation upon reversing the adverse effects of tobacco smoke on asthma control, therapeutic response to corticosteroids and airway pathology have yet to be fully elucidated. Alternative or additional therapies to inhaled corticosteroids are needed for asthmatic patients who are unable to quit smoking.

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“…They were selected because endoglin is a TGF-β coreceptor not known to be expressed on T cells; it was detected only on AD but not on AA patients. The IFN-α receptor β-chain might be important for STAT4-dependent T cell responses [42]and is of particular interest with respect to successful IFN-α therapies of steroid-resistant allergies [43]. Analysis of 6 AD patients revealed statistical significant differences for both endoglin and IFN-α receptor β-chain (fig.…”

Section: Introductionmentioning

confidence: 99%

DNA Arrays in Allergy and Immunology

Schmidt‐Weber¹,

Wohlfahrt²,

Blaser³

2001

Int Arch Allergy Immunol

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The DNA array technique allows the simultaneous analysis of multiple genes. This makes it an interesting tool for studies of gene expression in various diseases that are caused by or depend on multiple genes. DNA arrays are particularly applied to define certain immunological conditions such as allergic diseases. We summarize strategies on gene expression profiling of inflammatory disease and immunologically relevant cells using DNA array technology. Using DNA arrays, gene expression analysis of CD4+ T cells of allergy patients revealed interesting differences compared to healthy individuals, but also between different allergic conditions. This comparison demonstrated that T cells differed in their capacity to regulate peripheral tolerance, neuronal innervation, chemotaxis, neovascularization and epidermal growth. On the basis of these findings the DNA array technique appears to be especially interesting for the development of powerful diagnostic tools allowing fine specification and subtyping of allergic conditions, monitoring of therapy and of tailored therapy concepts.

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Treatment with IFN-α in corticosteroid-unresponsive asthma

Cited by 42 publications

References 5 publications

Cytokine modulators as novel therapies for airway disease

Cytokine modulators as novel therapies for airway disease

Asthma and cigarette smoking

DNA Arrays in Allergy and Immunology

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