Treatment with high intensity focused ultrasound: Secrets revealed

Shehata, Islam A.

doi:10.1016/j.ejrad.2011.01.047

Cited by 60 publications

(38 citation statements)

References 45 publications

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“…It has Doppler that allows real-time assessment of the vascularity of the treated area. The last monitor displays information regarding the circulation of the degassed water, allowing control of the level and temperature of the degassed water in the water reservoir [49]. …”

Section: Resultsmentioning

confidence: 99%

“…The most important one is to assess whether the lesion is seen by the integrated transducer or not. If the lesion cannot be clearly visualized the patient is unsuitable for HIFU treatment as the factors that hindered visualization of the tumor will likely hinder the passage of the therapeutic ultrasound during treatment [49]. …”

Section: Resultsmentioning

confidence: 99%

“…For uterine fibroids, contrast-enhanced MRI is needed. Reviewing findings from this imaging modality allows proper localization of subtle small lesions during the ultrasound scanning and helps planning the HIFU therapeutic path [49]. Sensitive structures adjacent to the fibroid must be identified so that the ultrasound beam does not pass through them [52,53].…”

Section: Resultsmentioning

confidence: 99%

“…If pain is experienced, short-acting analgesics may be used. Sexual intercourse is strictly forbidden until after the first menstruation following the treatment [49]. To assess the efficacy of the treatment, follow-up of the patients is crucial.…”

Section: Resultsmentioning

confidence: 99%

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High-Intensity Focused Ultrasound (HIFU) in Uterine Fibroid Treatment: Review Study

et al. 2014

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SummaryBackgroundHigh-intensity focused ultrasound (HIFU) is a highly precise medical procedure used locally to heat and destroy diseased tissue through ablation. This study intended to review HIFU in uterine fibroid therapy, to evaluate the role of HIFU in the therapy of leiomyomas as well as to review the actual clinical activities in this field including efficacy and safety measures beside the published clinical literature.Material/MethodsAn inclusive literature review was carried out in order to review the scientific foundation, and how it resulted in the development of extracorporeal distinct devices. Studies addressing HIFU in leiomyomas were identified from a search of the Internet scientific databases. The analysis of literature was limited to journal articles written in English and published between 2000 and 2013.ResultsIn current gynecologic oncology, HIFU is used clinically in the treatment of leiomyomas. Clinical research on HIFU therapy for leiomyomas began in the 1990s, and the majority of patients with leiomyomas were treated predominantly with HIFUNIT 9000 and prototype single focus ultrasound devices. HIFU is a non-invasive and highly effective standard treatment with a large indication range for all sizes of leiomyomas, associated with high efficacy, low operative morbidity and no systemic side effects.ConclusionsUterine fibroid treatment using HIFU was effective and safe in treating symptomatic uterine fibroids. Few studies are available in the literature regarding uterine artery embolization (UAE). HIFU provides an excellent option to treat uterine fibroids.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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High-Intensity Focused Ultrasound (HIFU) in Uterine Fibroid Treatment: Review Study

et al. 2014

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“…This temperature elevation causes localised tissue damage through coagulative necrosis [7,8]. With proper choice of operating frequency and transducer design, this can be achieved without significant biological damage to the intervening tissue [9,10].…”

Section: Introductionmentioning

confidence: 99%

Anatomical-based model for simulation of HIFU-induced lesions in atherosclerotic plaques

Almekkaway

Shehata

Ebbini

2015

International Journal of Hyperthermia

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Purpose: The aim of this study was to simulate the effect of high intensity focused ultrasound (HIFU) in non-homogenous medium for targeting atherosclerotic plaques in vivo. Materials and methods: A finite-difference time-domain heterogeneous model for acoustic and thermal tissue response in the treatment region was derived from ultrasound images of the treatment region. A 3.5 MHz dual mode ultrasound array suitable for targeting peripheral vessels was used. The array has a lateral and elevation focus at 40 mm with fenestration in its centre through which a 7.5 MHz diagnostic transducer can be placed. Two cases were simulated where seven adjacent HIFU shots ($5000 W/cm 2 , 2-s exposure time) were targeted on the plaque tissue within the femoral artery. The transient bioheat equation with a convective term to account for blood flow was used to predict the thermal dose. The results of the simulation model were then validated against the histology data. Results: The simulation model predicted the HIFU-induced damage for both cases, and correlated well with the histology data. For the first case thermal damage was detected within the targeted plaque, while for the second case thermal damage was detected in the pre-focal region. Conclusion: The results suggest that a realistic, image-based acoustic and thermal model of the treatment region is capable of predicting the extent of thermal damage to target plaque tissue. The model considered the effect of the wall thickness of large arteries and the heat-sink effect of flowing blood. The model is used for predicting the size and pattern of HIFU damage in vivo.

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