Treatment with fibrates is associated with higher LAL activity in dyslipidemic patients

Pavanello, Chiara; Baragetti, Andrea; Branchi, Adriana; Grigore, Liliana; Castelnuovo, S.; Giorgio, Eleonora; Catapano, Alberico L.; Calabresi, Laura; Gomaraschi, Monica

doi:10.1016/j.phrs.2019.104362

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…11 Studies have shown that circulating FFA is related to the occurrence and development of diseases such as metabolic syndrome, atherosclerosis, acute coronary syndrome and heart failure. [12][13][14] Experiments have confirmed that reactive oxygen radicals can induce cell apoptosis under certain conditions. 15 In addition, other studies have found that long-term local high temperature and repeated ischemia/reperfusion in athletes' tendons can produce an amount of reactive oxygen species, resulting in chronic tendinopathy.…”

Section: Introductionmentioning

confidence: 93%

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Proteomic analysis reveals rotator cuff injury caused by oxidative stress

Yuan

Qian

et al. 2021

Therapeutic Advances in Chronic Disease

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Background and aims: Rotator cuff tendinopathy is common and is related to pain and dysfunction. However, the pathological mechanism of rotator cuff injury and shoulder pain is unclear. Objective: to investigate the pathological mechanism of rotator cuff injury and shoulder pain, and screen out the marker proteins related to rotator cuff injury by proteomics. Methods: Subacromial synovium specimens were collected from patients undergoing shoulder arthroscopic surgery. The experimental group were patients with rotator cuff repair surgery, and the control group were patients with habitual dislocation of the shoulder joint. Pathological examination was performed, and then followed by non-labeled quantitative proteomic detection. Finally, from analysis of the biological information of the samples, specific proteins related to rotator cuff injury and shoulder pain were deduced by functional analysis of differential proteins. Results: All the patients in experimental groups were representative. A large number of adipocytes and inflammatory cells were found in the pathological sections of the experimental group; the proteomics analysis screen identified 80 proteins with significant differences, and the analysis of protein function revealed that S100A11 ( p = 0.011), PLIN4 ( p = 0.017), HYOU1 ( p = 0.002) and CLIC1 ( p = 0.007) were closely related to oxidative stress and chronic inflammation. Conclusion: Rotator cuff injury is closely related to oxidative stress and chronic inflammatory response, and the results suggest that the expression of S100A11, PLIN4, HYOU1 and CLIC1 in the synovium of rotator cuff injury provides a new marker for the study of its pathological mechanism.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Proteomic analysis reveals rotator cuff injury caused by oxidative stress

Yuan

Qian

et al. 2021

Therapeutic Advances in Chronic Disease

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“…extensively used as drugs for the treatment of high cholesterol levels caused by cardiovascular diseases and chronic kidney disease [3][4][5][6]. However, these fibrates are commonly detected in the aquatic environment [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Approximately 17.8 million people die from cardiovascular diseases and with their complications [1, 2]. Clofibrate and fenofibrate are blood lipid regulators Article Related Abbreviations: COF, covalent organic framework; CONs, covalent organic nanospheres; MSPE, magnetic solid-phase extraction; TAPA, tris(4-aminophenyl)amine; TFPA, tris(4-formylphenyl)amineextensively used as drugs for the treatment of high cholesterol levels caused by cardiovascular diseases and chronic kidney disease [3][4][5][6]. However, these fibrates are commonly detected in the aquatic environment [7,8].…”

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confidence: 99%

Covalent organic nanospheres modified magnetic nanoparticles for extraction of blood lipid regulators in water samples

Wan

Chen

2021

J of Separation Science

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Covalent organic nanospheres are new kind of nanospherical polymer with large specific surface area, uniform morphology, and excellent chemical and thermal stability. This material can be fabricated by a facile and rapid room temperature solution‐phase strategy. In this work, magnetic nanoparticles were attached to the surface of covalent organic nanospheres, and the obtained composites were used for the extraction of blood lipid regulators such as clofibrate and fenofibrate. These composites were characterized with Fourier‐transformed infrared spectroscopy, X‐ray photoelectron spectroscopy, and transmission electron microscopy. Several parameters that might affect the extraction efficiency including acetonitrile content, pH value, extraction time, and sample volume were investigated. Under optimum conditions, the proposed analytical method showed high extraction efficiency toward clofibrate and fenofibrate with enrichment factors between 60 and 83. This method exhibited outstanding analytical performance with wide linear range and excellent reproducibility and had low limits of detection in the range of 0.02–0.03 ng/mL. This method was also applied to the detection of clofibrate and fenofibrate in lake water samples, and good recoveries in the range of 92.6–112.6% was obtained.

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“…However, side effects of such drugs include that the drug reactivity of individuals varies greatly and the increased risk of bleeding in patients have not been effectively addressed [5]. Other essential drugs for treating atherosclerosis are lipid-lowing drugs, among which the mainstream drugs include HMG-CoA reductase inhibitors, such as statins [6] and brates [7] that enhance high density lipoprotein (HDL) synthesis. These drugs inhibit the development of atherosclerosis by improving the lipid pro le.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyurea Regressed Atherosclerosis Plaques in ApoE-/- Mice: A Discovery Based on Clinic

Tong

Yang

Ma³

et al. 2020

Preprint

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Background: A 58-year-old lady was introduced to the clinic because of acute coronary syndrome combined with essential thrombocythemia. After coronary artery bypass grafting. After treating her with aspirin, statins and hydroxyurea (HU), the plaques in her coronary arteries showed improvement dramatically. Here, we aim to investigate that HU might regress atherosclerosis plaques in ApoE−/− mice and the potential mechanism.Methods: Wild-type (C57BL/6, n = 8) and Apolipoprotein E knockout (ApoE-/-, n = 40) mice were used in atherosclerosis model and medication groups. The mice were separated into 7 groups, including the normal control group, the atherosclerosis model group, the dual antiplatelet therapy group (aspirin, and clopidogrel bisulfate), the low-dose and high-dose HU therapy groups [aspirin, clopidogrel bisulfate, and HU (10 or 20 mg/kg/day)], the positive medicine group (aspirin, clopidogrel bisulfate, and atorvastatin calcium), and the combined medicine treatment group [aspirin, clopidogrel bisulfate, atorvastatin calcium, and HU (10 mg/kg/day)]. Fasting serum and aortic vessels were obtained after experiment. The aortic oil red O, Hematoxylin-eosin, and full-length oil red O staining was performed to evaluate the HU’s efficacy of anti- atherosclerosis, and the investigation of HU mechanisms was carried out in HepG2 cells for proprotein convertase subtilisin/kexin type 9 (PCSK9) level.Results: The oil red O and H&E staining results came out that HU therapy with antiplatelet showed an obvious effect in decreasing atherosclerosis plaques and the effect of HU therapy (10 or 20 mg/kg) was stronger than dual antiplatelet therapy plus statin, without liver and kidney toxicity observed. Furthermore, the combined drugs with HU (10 mg/kg/day), statin and antiplatelet nearly eliminated the plaques. One of the possible mechanisms of HU might be related with the inhibition of PCSK9.Conclusions: A discovery based on clinic reveals that HU regressed atherosclerosis plaques in ApoE-/- mice, which provides us a new insight into anti-atherosclerosis drugs strategy. PCSK9 could be one of the possible mechanisms and further mechanisms need to be explored.

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Treatment with fibrates is associated with higher LAL activity in dyslipidemic patients

Cited by 5 publications

References 23 publications

Proteomic analysis reveals rotator cuff injury caused by oxidative stress

Proteomic analysis reveals rotator cuff injury caused by oxidative stress

Covalent organic nanospheres modified magnetic nanoparticles for extraction of blood lipid regulators in water samples

Hydroxyurea Regressed Atherosclerosis Plaques in ApoE-/- Mice: A Discovery Based on Clinic

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