Treatment with bergamot (Citrus bergamia) leaves extract attenuates leptin resistance in obese rats

Nakandakare-Maia, Erika Tiemi; Siqueira, Juliana Silva; Ferron, Artur Júnio Togneri; Vieira, Taynara Aparecida; Palacio, Thiago Luiz Novaga; Grandini, Núbia Alves; Garcia, Jéssica Leite; Belin, Matheus Antônio Filiol; Altomare, Alessandra; Baron, Giovanna; Aldini, Giancarlo; Francisqueti-Ferron, Fabiane Valentini; Corrêa, Camila Renata

doi:10.1016/j.mce.2023.111908

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…Regarding the role of bergamot derivatives and byproducts on metabolic disorders, it was seen that a bergamot leaf extract (BLE) is able to decrease inflammation (TNF-α and IL-6 levels) and oxidative stress, acting on the adipose tissue–liver axis of obese rats, with an effect which might improve both insulin resistance and dyslipidemia conditions [ 85 ]. In the same experimental model, BLE was also studied at the hypothalamic level, where it reduced the inflammation (decreasing the production of cytokine signaling (SOCS) 3, IL-6 and TNF-α and activating the JAK2/STAT3 pathway) and oxidative stress, thus counteracting the resistance to leptin (known as the “satiety hormone”) of obese rats [ 86 ]. Clinically, a nutraceutical containing bergamot extract was shown to improve systemic inflammation, significantly reducing high-sensitivity C-reactive protein (hs-CRP) and TNF-α levels in dyslipidemic overweight subjects [ 87 ].…”

Section: Anti-inflammatory Activity Of Bergamot Derivatives and Bypro...mentioning

confidence: 99%

Bergamot Byproducts: A Sustainable Source to Counteract Inflammation

Russo,

Lombardo,

Bruschetta

et al. 2024

Nutrients

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Chronic inflammation is the result of an acute inflammatory response that fails to eliminate the pathogenic agent or heal the tissue injury. The consequence of this failure lays the foundations to the onset of several chronic ailments, including skin disorders, respiratory and neurodegenerative diseases, metabolic syndrome, and, eventually, cancer. In this context, the long-term use of synthetic anti-inflammatory drugs to treat chronic illnesses cannot be tolerated by patients owing to the severe side effects. Based on this, the need for novel agents endowed with anti-inflammatory effects prompted to search potential candidates also within the plant kingdom, being recognized as a source of molecules currently employed in several therapeutical areas. Indeed, the ever-growing evidence on the anti-inflammatory properties of dietary polyphenols traced the route towards the study of flavonoid-rich sources, such as Citrus bergamia (bergamot) and its derivatives. Interestingly, the recent paradigm of the circular economy has promoted the valorization of Citrus fruit waste and, in regard to bergamot, it brought to light new evidence corroborating the anti-inflammatory potential of bergamot byproducts, thus increasing the scientific knowledge in this field. Therefore, this review aims to gather the latest literature supporting the beneficial role of both bergamot derivatives and waste products in different models of inflammatory-based diseases, thus highlighting the great potentiality of a waste re-evaluation perspective.

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Section: Anti-inflammatory Activity Of Bergamot Derivatives and Bypro...mentioning

confidence: 99%

Bergamot Byproducts: A Sustainable Source to Counteract Inflammation

Russo,

Lombardo,

Bruschetta

et al. 2024

Nutrients

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“…In the 20th week, when hypertriglyceridemia (C: 93.0 ± 38.2 vs. HSF: 139.5 ± 69.7, p < 0.001) and insulin resistance (C: 3.8 ± 0.9 vs. HSF: 5.5 ± 1.3, p < 0.001) were detected in the HSF group, a separation point (SP) was adopted once animals exposed to different diet models did not always present the expected response [19,21]. After that, the control and HSF groups of animals, above and below the SP, respectively, were excluded from the experiment.…”

Section: Experimental Protocol and Group Characterizationmentioning

confidence: 99%

“…The consumption of the chow and water of each animal were measured weekly, and the caloric intake was determined by multiplying the energy value of each diet (g × Kcal). The epididymal, visceral and retroperitoneal fat deposits were dissected during euthanasia and used as a sign of obesity using the adiposity index determination, following the formula: Adiposity index = [(Epididymal fat + Visceral fat + Retroperitoneal fat)/final body weight] × 100 [21,22].…”

Section: Analysis Of Nutrition and Metabolismmentioning

confidence: 99%

Effect of Bergamot Leaves (Citrus bergamia) in the Crosstalk between Adipose Tissue and Liver of Diet-Induced Obese Rats

Siqueira

Nakandakare-Maia

Vieira

et al. 2023

Livers

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The excessive consumption of diets rich in sugar and fat is associated with metabolic manifestations involving adipose tissue and the liver. Bergamot, due to its antioxidant and anti-inflammatory properties, has been used to treat metabolic disorders. This work aimed to verify the effect of Bergamot leaves extract (BLE) on the crosstalk in the adipose tissue–liver axis of obese rats. For 20 weeks, Wistar rats were distributed into two groups: control (Control) and high sugar–fat (HSF) diet groups. Afterwards, the animals were redistributed into three groups for 10 weeks: control diet + vehicle (Control, n = 08), HSF + vehicle (HSF, n = 08), and HSF + BLE (HSF + BLE, n = 08). The BLE was carried out daily by gavage (50 mg/kg). The HSF group presented obesity, hyperglycemia, hypertriglyceridemia, insulin resistance, hepatic microvesicular steatosis, higher inflammation and oxidative stress in the liver and adipose tissue. In comparison to the HSF group, HSF + BLE animals showed protection by reducing the triglyceride levels, insulin resistance, inflammation and oxidative stress in hepatic and adipose tissues. BLE acted on the inflammation and oxidative stress in the adipose tissue–liver axis in obese rats when compared to the HSF group, which may have reflected on the improvement of insulin resistance and dyslipidemia.

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Recovery of nutraceutical compounds from citrus fruit processing waste: A circular economy strategy to lessen environmental impact

Navarra,

Tellone

2024

Future Postharvest and Food

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Treatment with bergamot (Citrus bergamia) leaves extract attenuates leptin resistance in obese rats

Cited by 3 publications

References 27 publications

Bergamot Byproducts: A Sustainable Source to Counteract Inflammation

Bergamot Byproducts: A Sustainable Source to Counteract Inflammation

Effect of Bergamot Leaves (Citrus bergamia) in the Crosstalk between Adipose Tissue and Liver of Diet-Induced Obese Rats

Recovery of nutraceutical compounds from citrus fruit processing waste: A circular economy strategy to lessen environmental impact

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