Abstract:IMPORTANCE Retinitis pigmentosa (RP) is the leading cause of incurable inherited blindness in the developed world, with an estimated prevalence of 1 in 3500 individuals. Therefore, it is important to develop new treatments for this disease. OBJECTIVE To determine the effect of oral treatment with 9-cis β-carotene on visual function of patients with RP. DESIGN Randomized, double-masked, placebo-controlled, crossover clinical trial. SETTING University tertiary medical facility. PARTICIPANTS Thirty-four patients … Show more
“…Finally, 8 studies informed in 13 articles were included in the present review. [9][10][11][12][13][14][15][16][17][18][19][20][21] Characteristics of studies…”
Section: Resultsmentioning
confidence: 99%
“…All are randomised controlled trials, with a parallel design, 9,10,13,14,16 a crossover design, 11,19,18 or a factorial design. 12 Except Lee et al which studied Best disease, 18 all included studies are on RP.…”
Section: Resultsmentioning
confidence: 99%
“…12 Except Lee et al which studied Best disease, 18 all included studies are on RP. [9][10][11][12][13][14][15][16][17][19][20][21] They assessed supplements based on vitamin A and vitamin E, 12 docosahexaenoic acid (DHA), 9,10,14,16,18 and the carotenoids lutein, 11,13 and β-carotene. 19 We did not identify eligible studies about other HRDs.…”
Section: Resultsmentioning
confidence: 99%
“…18 The study by Bahrami et al has an important limitation regarding the method used for data recording, as they were documented by participants on their own using their personal computers. 11 All studies performed intention-to-treat analysis with the exception of Rotenstreich et al 19 Figure 1 Flowchart for the selection of studies. …”
Section: Resultsmentioning
confidence: 99%
“…13 Finally, another carotenoid, 9-cis-β-carotene from Dunaliella alga, was supplemented for 3 months on a crossover basis in the study by Rotenstreich et al, allowing a 3-month washout period between treatments. 19 Visual acuity Table 3 summarises the results for visual acuity. Berson et al reported a decline of visual acuity per year in all groups, with the larger decline in the group supplemented with both Vitamin A and E; however, the authors reported no significant differences among the four study arms (P-values were not reported).…”
“…Finally, 8 studies informed in 13 articles were included in the present review. [9][10][11][12][13][14][15][16][17][18][19][20][21] Characteristics of studies…”
Section: Resultsmentioning
confidence: 99%
“…All are randomised controlled trials, with a parallel design, 9,10,13,14,16 a crossover design, 11,19,18 or a factorial design. 12 Except Lee et al which studied Best disease, 18 all included studies are on RP.…”
Section: Resultsmentioning
confidence: 99%
“…12 Except Lee et al which studied Best disease, 18 all included studies are on RP. [9][10][11][12][13][14][15][16][17][19][20][21] They assessed supplements based on vitamin A and vitamin E, 12 docosahexaenoic acid (DHA), 9,10,14,16,18 and the carotenoids lutein, 11,13 and β-carotene. 19 We did not identify eligible studies about other HRDs.…”
Section: Resultsmentioning
confidence: 99%
“…18 The study by Bahrami et al has an important limitation regarding the method used for data recording, as they were documented by participants on their own using their personal computers. 11 All studies performed intention-to-treat analysis with the exception of Rotenstreich et al 19 Figure 1 Flowchart for the selection of studies. …”
Section: Resultsmentioning
confidence: 99%
“…13 Finally, another carotenoid, 9-cis-β-carotene from Dunaliella alga, was supplemented for 3 months on a crossover basis in the study by Rotenstreich et al, allowing a 3-month washout period between treatments. 19 Visual acuity Table 3 summarises the results for visual acuity. Berson et al reported a decline of visual acuity per year in all groups, with the larger decline in the group supplemented with both Vitamin A and E; however, the authors reported no significant differences among the four study arms (P-values were not reported).…”
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