Treatment variables in relation to oocyte maturation: Lessons from a clinical micromanipulation-assisted in vitro fertilization program

Avrech, Ori M.; Goldman, Gideon; Rufas, Onit; Stein, Anat; Amit, S.; Yoles, Israel; Pinkas, Haim; Fisch, Benjamin

doi:10.1007/bf02765838

Cited by 18 publications

(10 citation statements)

References 29 publications

(34 reference statements)

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“…Avrech et al demonstrated that ICSI cycles yielding higher response rates and greater numbers of oocytes were associated with more immature oocytes (11). The present patient certainly had a high response rate, averaging 28 oocytes per cycle, whereas the average 28-year-old woman undergoing ICSI in our practice produced 16 oocytes per cycle (Mann-Whitney: P¼.02).…”

Section: Discussionmentioning

confidence: 61%

Turner mosaicism (45,X/46,XX) diagnosed in a young woman subsequent to low oocyte maturity and failed ICSI

Moore

Lynch

Arny

et al. 2008

Fertility and Sterility

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Section: Discussionmentioning

confidence: 61%

Turner mosaicism (45,X/46,XX) diagnosed in a young woman subsequent to low oocyte maturity and failed ICSI

Moore

Lynch

Arny

et al. 2008

Fertility and Sterility

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“…Although complete failure of oocytes to complete meiosis maturation during assisted conception cycles is rare, occasional and repetitive maturation resistance does occur in infertile patients (Avrech et al, 1997;Bar-Ami et al, 1994;Beall et al, 2010;Heindryckx et al, 2011). Patients presenting with an abnormally high number of immature oocytes at retrieval show a high probability of exhibiting maturation resistant oocytes, although the influence of such an event on the nuclear maturation competence, as well as on the subsequent pregnancy outcomes of these patients, have not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Patients with a high proportion of immature and meiotically resistant oocytes experience defective nuclear oocyte maturation patterns and impaired pregnancy outcomes

Yang

Ferrer-Buitrago

Popovic

et al. 2018

Reproductive BioMedicine Online

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Patients presenting with abnormally high numbers of immature oocytes at retrieval are more likely to exhibit maturation resistant oocytes. However, the clinical relevance of such events remains unknown. We investigated nuclear maturation competence of immature oocytes from patients showing >40% of collected immature oocytes (Study group) and Controls, in which a normal number of mature oocytes (≥60%) was retrieved. Following in-vitro culture, oocytes were classified as maturation resistant or in-vitro matured (IVM). Treatment outcomes were evaluated in Study and Control groups based on presence of maturation resistant oocytes. Overall, similarly high spindle and chromosome abnormality rates were observed in maturation resistant oocytes from both Study and Control groups. IVM oocytes from the Study group revealed significantly higher percentages of misaligned chromosomes compared with Controls (P < 0.05). Remarkably, Study group patients with at least one maturation resistant oocyte showed significantly reduced cumulative pregnancy and live birth rates compared with Control group maturation resistant patients (P < 0.05). When further investigating the aetiology, a maturation resistant mouse model revealed defective Ca signalling of maturation resistant oocytes at germinal vesicular breakdown and parthenogenetic activation. In conclusion, appropriate treatment strategies, including clinical utilization of IVM oocytes from Study group patients, warrant further investigation.

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“…Approximately 20%–30% of oocytes collected for IVF are meiotically immature at the time of oocyte retrieval,[ 9 ] and this is probably because of the stimulation of multiple follicles. When the percentage of incompetent oocytes was ≥25%, most of the IVF outcomes were markedly reduced.…”

Section: Discussionmentioning

confidence: 99%

Maturation arrest of human oocytes at germinal vesicle stage

2010

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Maturation arrest of human oocytes may occur at various stages of the cell cycle. A total failure of human oocytes to complete meiosis is rarely observed during assisted conception cycles. We describe here a case of infertile couples for whom all oocytes repeatedly failed to mature at germinal vesicle (GV) stage during in vitro fertilization/Intra cytoplasmic sperm injection (IVF/ICSI). The patient underwent controlled ovarian stimulation followed by oocyte retrieval and IVF/ICSI. The oocytes were stripped off cumulus cells prior to the ICSI procedure and their maturity status was defined. The oocyte maturation was repeatedly arrested at the GV. Oocyte maturation arrest may be the cause of infertility in this couple. The recognition of oocyte maturation arrest as a specific medical condition may contribute to the characterization of the currently known as “oocyte factor.” The cellular and genetic mechanisms causing oocyte maturation arrest should be the subject for further investigation.

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Treatment variables in relation to oocyte maturation: Lessons from a clinical micromanipulation-assisted in vitro fertilization program

Abstract: Objective: In an effort to understand the mechanism underlying the improved pregnancy rate observed in IVF cycles when gonadotropin-releasing hormone analogues ( GnRH-a )

Cited by 18 publications

References 29 publications

Turner mosaicism (45,X/46,XX) diagnosed in a young woman subsequent to low oocyte maturity and failed ICSI

Turner mosaicism (45,X/46,XX) diagnosed in a young woman subsequent to low oocyte maturity and failed ICSI

Patients with a high proportion of immature and meiotically resistant oocytes experience defective nuclear oocyte maturation patterns and impaired pregnancy outcomes

Maturation arrest of human oocytes at germinal vesicle stage

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