Treatment Techniques and Site Considerations Regarding Dysphagia-Related Quality of Life in Cancer of the Oropharynx and Nasopharynx

Factors Affecting the Success of Endoscopic Bougia Dilatation of Radiation-Induced Esophageal Stricture

“…Teguh et al demonstrated that patients with base of tongue disease experienced more severe dysphagia than those with tumors at other sites [12]. In addition to oropharynx primary, the larynx, hypopharynx and pharyngeal wall were also found to predispose to dysphagia more so than other regions of the head and neck [13,14].…”

Dysphagia in Head and Neck Cancer Patients Treated with Chemoradiotherapy

“…Post-RT swallowing disorders are due to primarily neuromuscular fibrosis and radiation-induced edema [19,20]. RT induces hyperactivation through hydroxyl radicals of transforming growth factor-b1 (TGF-b1) which plays a role in collagen deposition and degradation.…”

Volumetric modulated arc therapy (VMAT) and simultaneous integrated boost in head-and-neck cancer: is there a place for critical swallowing structures dose sparing?

“…The most predictive dosimetric indices for the PCMs were found to be the mean dose [14][15][16][17][18][19] and the volume receiving more than 60 Gy 14,18 and 65 Gy 14,31 in the uPCM. Similarly, the most predictive dosimetric indices for the SGL were the mean dose 17,20 and the volume receiving .50 Gy.…”

“…13 Several clinical trials have analysed the relationship between the irradiated tissues and dysphagia assessing consistent data for the crucial structures related to swallowing dysfunction. [14][15][16][17][18][19][20] In particular, pharyngeal constrictors muscles (PCM) and the glottic/supraglottic larynx (SGL) have been identified as principal organs in which dysfunction after chemoradiation causes dysphagia and aspiration. 21 The common findings of these studies were that increased radiation dose to these structures resulted in higher level of dysphagia, all demonstrating a significant correlation between dysphagia/aspiration and the mean doses to PCM and SGL.…”