Treatment success using novel and adapted treatment regimens in registered DR-TB children in Dushanbe, Tajikistan, 2013-2019

Abstract

Introduction: Approximately 3% of all pediatric TB cases develop MDR-TB, with only 3–4% of such children receiving MDR-TB treatment. In Tajikistan, children as a proportion of all DR-TB in the country increased from 4.3 to 7.5% during 2013-2018. Despite limited evidence on the use of new anti-TB drugs in children, WHO has updated its guidelines for DR-TB treatment for children, and Tajikistan did so in 2013 and 2017. Novel and adapted regimens included individual regimens for RR/MDR, XDR (with and without Bedaquiline and Delamanid) and short treatment regimens with and without injectables. It is important to document the outcomes of the treatment regimens. Therefore, the aim of this study was to describe characteristics of children receiving different treatment regimens for DR-TB, the culture conversion and treatment outcomes.
 Methodology: Cohort study of children enrolled in DR-TB treatment by the National Tuberculosis Program in Dushanbe, Tajikistan, January 2013 to July 2019.
 Results: The study included 60 DR-TB children. The male to female ratio was 1:2 and mean age 13.6 years. Median time to culture conversion was 66 days [IQR:31-103; Range:2-232]. In children with treatment outcomes (N = 58), 93% had favorable outcomes. There were four children (7%) with unfavorable treatment outcomes, all of whom were female 15-17 years, on standard (RR/MDR) treatment during 2013-2015. Favorable outcomes by DR-TB type were 91%, 90%, and 100% in RR/MDR, PreXDR, and XDR-TB patients, respectively.
 Conclusions: All children enrolled after the introduction of modified guidelines for novel and adapted regimens for DR-TB showed positive TB treatment outcomes.

Delamanid-containing regimens and multidrug-resistant tuberculosis: A systematic review and meta-analysis

“…Of these, 42 articles were selected for a full-text review. After the full-text review, 25 articles met the inclusion criteria (Auchynka et al, 2021;Chang et al, 2018;Das et al, 2020;Das et al, 2021;Dooley et al, 2021;Ferlazzo et al, 2018;Ghosh et al, 2021;Gler et al, 2012;Häcker et al, 2020;Hafkin et al, 2017, Hafkin et al, 2019Hewison et al, 2017;Kang et al, 2020;Kim et al, 2018;Kuksa et al, 2017;Kwon et al, 2021;Lee et al, 2020;Madzgharashvili et al, 2021;Mohr-Holland et al, 2020;Mok et al, 2019;Olayanju et al, 2020;Pirmahmadzoda et al, 2021;Sarin et al, 2019;Solodovnikova et al, 2021;von Groote-Bidlingmaier et al, 2019) of which 22 were observational (with 1,276 patients) (Auchynka et al, 2021;Chang et al, 2018;Das et al, 2020;Das et al, 2021;Ferlazzo et al, 2018;Ghosh et al, 2021;Häcker et al, 2020;Hafkin et al, 2017;Hafkin et al, 2019;Hewison et al, 2017;Kang et al, 2020;Kim et al, 2018;Kuksa et al, 2017;Kwon et al, 2021;…”

“…Of these, 42 articles were selected for a full-text review. After the full-text review, 25 articles met the inclusion criteria ( Auchynka et al., 2021 ; Chang et al., 2018 ; Das et al., 2020 ; Das et al., 2021 ; Dooley et al., 2021 ; Ferlazzo et al., 2018 ; Ghosh et al., 2021 ; Gler et al., 2012 ; Häcker et al., 2020 ; Hafkin et al., 2017 , Hafkin et al., 2019 ; Hewison et al., 2017 ; Kang et al., 2020 ; Kim et al., 2018 ; Kuksa et al., 2017 ; Kwon et al., 2021 ; Lee et al., 2020 ; Madzgharashvili et al., 2021 ; Mohr-Holland et al., 2020 ; Mok et al., 2019 ; Olayanju et al., 2020 ; Pirmahmadzoda et al., 2021 ; Sarin et al., 2019 ; Solodovnikova et al., 2021 ; von Groote-Bidlingmaier et al., 2019 ) of which 22 were observational (with 1,276 patients) ( Auchynka et al., 2021 ; Chang et al., 2018 ; Das et al., 2020 ; Das et al., 2021 ; Ferlazzo et al., 2018 ; Ghosh et al., 2021 ; Häcker et al., 2020 ; Hafkin et al., 2017 ; Hafkin et al., 2019 ; Hewison et al., 2017 ; Kang et al., 2020 ; Kim et al., 2018 ; Kuksa et al., 2017 ; Kwon et al., 2021 ; Lee et al., 2020 ; Madzgharashvili et al., 2021 ; Mohr-Holland et al., 2020 ; Mok et al., 2019 ; Olayanju et al., 2020 ; Pirmahmadzoda et al., 2021 ; Sarin et al., 2019 ; Solodovnikova et al., 2021 ;) and three experimental studies (with 411 patients) ( Dooley et al., 2021 ; Gler et al., 2012 ; von Groote-Bidlingmaier et al., 2019 ) ( Tables 1 and…”