Treatment strategy for resectable colorectal cancer liver metastases from the viewpoint of time to surgical failure

Hirokawa, Fumitoshi; Ueno, Masaki; Nakai, Toshiko; Kaibori, Masaki; Nomi, Takeo; Iida, Hiroya; Tanaka, Shogo; Koyama, Koji; Hayami, Shinya; Kosaka, Hisashi; Hokuto, Daisuke; Kubo, Shoji; Uchiyama, Kazuhisa

doi:10.1007/s00423-021-02372-w

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…The liver is one of the most common metastatic sites of advanced solid tumors (1)(2)(3)(4). Hematological metastasis is the main cause of liver metastasis in colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance and changes to the immune microenvironment of colorectal cancer patients with liver metastasis

Wang¹,

Tang²,

Ouyang³

et al. 2023

J Gastrointest Oncol

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Background: Liver metastasis is common in colorectal cancer patients. Immunotherapy covers a wide range of tumor types and is safer than traditional radiotherapy and chemotherapy. However, its overall effective rate is only 20-40%. At present, there is a lack of relevant research clarifying whether the changes and clinical significance of the immune microenvironment in colorectal cancer patients with liver metastasis are conducive to enhancing the promotion and further improving the efficacy of immunotherapy. Methods:We retrospectively collected the data of 50 colorectal cancer patients with liver metastasis treated in Chongqing University Cancer Hospital from January 2017 to January 2019. Liver metastatic cancer tissues and normal liver tissues were collected to detect the levels of immune cells in the two samples. At the same time, the correlation between T-cell subsets in the liver metastatic cancer tissue immune microenvironments of colorectal cancer patients and prognosis was analyzed.Results: Compared with the normal liver tissues, the level of T helper cell 1/T helper cell 2 (Th1/Th2) in the liver metastatic cancer tissues was significantly decreased (0.88±0.24 vs. 1.34±0.27, P=0.000), while the levels of regulatory T cells were markedly increased (8.57±2.31 vs. 6.89±1.71, P=0.000). The Th1/Th2 level in liver metastatic cancer tissue exhibited a good predictive value for recurrence and survival 3 years after surgery, and the areas under the curves were 0.783 (95% confidence interval: 0.649-0.916, P=0.002) and 0.763 (95% confidence interval: 0.628-0.898, P=0.001), respectively. Moreover, the regulatory T-cell level in liver metastatic cancer tissue had a good predictive value for recurrence and survival at 3 years postoperatively, and the areas under the curves were 0.788 (95% confidence interval: 0.656-0.919, P=0.002) and 0.763 (95% confidence interval: 0.628-0.897, P=0.001), respectively. Conclusions:The immunosuppressive condition of liver metastasis in colorectal cancer patients was related to poor prognosis.

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“…The liver is one of the most common metastatic sites of advanced solid tumors (1)(2)(3)(4). Hematological metastasis is the main cause of liver metastasis in colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance and changes to the immune microenvironment of colorectal cancer patients with liver metastasis

Wang¹,

Tang²,

Ouyang³

et al. 2023

J Gastrointest Oncol

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“…However, the effect of age on the long-term outcome of CRLM remains unclear. Several retrospective studies have suggested that older people have a poorer prognosis than younger people [ 17 , 18 ], while another study reported that age above 60 years was not associated with poorer long-term survival [ 19 ]. In addition, Alexandre et al found that early-onset CRLM (EOCRLM) demonstrated comparable long-term survival to late-onset CRLM (LOCRLM) and showed that age may affect the prognostic value of RAS mutations [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Age of Onset on Survival after Hepatectomy for Patients with Colorectal Cancer Liver Metastasis: A Real-World Single-Center Experience

Wang

Jin

et al. 2022

Current Oncology

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Purpose: The incidence of early-onset CRC is increasing. However, the effect of age of onset on the long-term outcome of colorectal cancer liver metastasis (CRLM) remains unclear. This study aimed to evaluate the association between the age of onset and the oncological outcome of CRLM patients and to investigate whether the prognostic role of RAS mutation is altered with age. Methods: We retrospectively investigated consecutive patients at our institution who underwent initial liver resection between 2006 and 2020. The inverse probability of treatment weighting (IPTW) method was used to balance the confounders among early- (≤45 years; EOCRLM), intermediate- (46–70 years; IOCRLM), and late-onset (>70 years; LOCRLM) groups. The prognostic role of RAS was assessed based on age group. Results: A total of 1189 patients were enrolled: 162 in the EOCRLM group, 930 in the IOCRLM group, and 97 in the LOCRLM group. No difference in disease-free survival (DFS) was found between the three groups. However, EOCRLM were more likely to develop extrahepatic and extrapulmonary metastasis and had significantly lower five-year OS rates than IOCRLM. After IPTW, EOCRLM remained a negative prognostic predictor. RAS mutations were significantly associated with worse survival than wild-type RAS in EOCRLM and IOCRLM. However, RAS mutation did not predict the prognosis of patients with LOCRLM. Conclusions: Patients with EOCRLM had a significantly lower OS than IOCRLM patients and age influences the prognostic power of RAS status. These findings may be helpful for doctors to guide the clinical treatments and develop follow-up strategies.

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Treatment strategy for resectable colorectal cancer liver metastases from the viewpoint of time to surgical failure

Cited by 2 publications

References 33 publications

Clinical significance and changes to the immune microenvironment of colorectal cancer patients with liver metastasis

Clinical significance and changes to the immune microenvironment of colorectal cancer patients with liver metastasis

Impact of Age of Onset on Survival after Hepatectomy for Patients with Colorectal Cancer Liver Metastasis: A Real-World Single-Center Experience

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