Treatment strategies for rectal cancer with synchronous liver metastases: surgical and oncological outcomes with propensity-score analysis

Salvador-Rosés, Helena; López‐Ben, Santiago; Planellas, Pere; Canals, E; Casellas-Robert, Margarida; Farrés, Ramón; Ramos, Emilio; Codina‐Cazador, A.; Figueras, Joan

doi:10.1007/s12094-017-1712-4

Cited by 6 publications

(2 citation statements)

References 30 publications

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“…All 12 included studies [24][25][26][27][28][29][30][31][32][33][34][35] were retrospective cohort studies, and no randomised controlled trial was performed. Most of the included studies were conducted in Europe, with two studies from the United States and one study from Japan.…”

Section: Selection Of Trials and Patient Characteristicsmentioning

confidence: 99%

Evaluating the outcomes of liver‐first approach for liver metastases due to colorectal cancer: A systematic review and meta‐analysis

et al. 2022

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Purpose Surgery is the mainstay treatment for colorectal cancer and offers a long‐term survival benefit for patients with liver metastases; however, the appropriate approach remains debatable. We aimed to systematically review and perform a meta‐analysis of liver‐first and classical (colon‐first) approaches. Methods The following electronic databases were searched for systematic literature: PubMed and the Cochrane Library. Studies that compared patients with liver metastases due to colorectal cancer and who underwent liver‐first and classical resections were selected. Primary outcomes were long‐term overall survival and disease‐free survival, and secondary outcomes were perioperative morbidity and mortality. Results Over 12 studies with 6344 patients were analysed; of the total patients, 1141 and 4552 underwent liver‐first resection and classical resection, respectively. The meta‐analysis showed no significant difference between the liver‐first resection group and classical resection group in terms of overall morbidity (risk ratio [RR] 1.26, 95% confidence interval [CI] 0.91‐1.74) and 90‐day mortality (RR 1.26, 95% CI 0.52‐3.04, P = .23). The classical resection group showed favourable overall survival and disease‐free survival than the liver‐first resection group in the nonpropensity score‐matched studies (RR 1.19, 95% CI 1.09‐1.3) but showed comparable results in the propensity score‐matched studies (RR 1.07, 95% CI 0.97‐1.18). Conclusions The perioperative and long‐term outcomes of the liver‐first and classical approaches were comparable. Selection of the appropriate approach that will be used for a patient depends on the characteristics of the primary colorectal tumour and the occurrence of liver metastases.

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Section: Selection Of Trials and Patient Characteristicsmentioning

confidence: 99%

Evaluating the outcomes of liver‐first approach for liver metastases due to colorectal cancer: A systematic review and meta‐analysis

et al. 2022

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“…An alternative approach in addition to ‘liver first’ or ‘rectal first’ is ‘the interval strategy’ that involves the administration of LC-CRT followed by the resection of the CRLM in the interval between RT and rectal surgery. 9 , 10 For these reasons, all patients must be evaluated by a specialist multidisciplinary team (MDT).…”

Section: All Patients Must Be Evaluated By a Multidisciplinary Teammentioning

confidence: 99%

Synchronous liver metastases in patients with rectal cancer: can we establish which treatment first?

2018

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Neoadjuvant Pelvic Radiotherapy in the Management of Rectal Cancer with Synchronous Liver Metastases: Is It Worth It?

Moslim

Bastawrous

Jeyarajah

2021

Journal of Gastrointestinal Surgery

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Treatment strategies for rectal cancer with synchronous liver metastases: surgical and oncological outcomes with propensity-score analysis

Abstract: This study supports the notion that the achievement of CR of RC and SLM should be the goal of oncological treatment. Both RF and LF strategies are feasible and safe, but no between-strategy differences have been found in the CRR.

Cited by 6 publications

References 30 publications

Evaluating the outcomes of liver‐first approach for liver metastases due to colorectal cancer: A systematic review and meta‐analysis

Evaluating the outcomes of liver‐first approach for liver metastases due to colorectal cancer: A systematic review and meta‐analysis

Synchronous liver metastases in patients with rectal cancer: can we establish which treatment first?

Neoadjuvant Pelvic Radiotherapy in the Management of Rectal Cancer with Synchronous Liver Metastases: Is It Worth It?

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