Treatment strategies and outcomes for spinal rhabdomyosarcoma: A series of 11 cases in a single center and review of the literature

Wang, Tao; Gào, Xīn; Yang, Jian; Guo, Wen; Wu, Zheyu; Tang, Liang; Cao, Shuang; Cai, Xiaopan; Liu, Tielong; Jia, Qi; Xiao, Jianru

doi:10.1016/j.clineuro.2020.105729

Cited by 8 publications

(23 citation statements)

References 24 publications

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“…Overall, the cure rate of RMS could be increased with the improvements in risk stratifications and multimodal treatment including surgery, chemotherapy, and radiotherapy ( 40 , 41 ). As for retroperitoneal RMS, surgery, especially radical resection, is the principal choice, with a longer median OS than palliative surgery and conservative treatment (18 vs. 6 months) ( 9 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, retroperitoneal ARMS is extremely rare and has poor outcomes accompanied by the large tumor volume and frequent involvement of vital organs, leading to difficult resection when it is diagnosed ( 7 ). Due to the specific anatomical location, retroperitoneal, especially paraspinal, ARMS shows the potential to infiltrate the vertebrae and protrude into the spinal canal ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Retroperitoneal alveolar rhabdomyosarcoma intruding into spinal canal: A case report and literature review

Zhang

Huang

et al. 2022

Front. Med.

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BackgroundRhabdomyosarcoma (RMS) is the most frequent soft sarcoma in children and adolescents. Alveolar rhabdomyosarcoma (ARMS) is a relatively rare subtype that is characterized by aggressive behavior and an unsatisfactory prognosis. An ARMS can arise anywhere but most commonly occurs at extremity sites with a very small fraction in the retroperitoneum. The utility of 2-Deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) positron emission tomography combined with computed tomography (PET/CT) remains to be established in ARMS.Case ReportA 3-year-old female child was accidentally found with a large left upper abdominal mass for a day. CT examination indicated a huge soft tissue mass in the left retroperitoneum extending superiorly to the level of the left hilus renalis and inferiorly to the left acetabulum in the pelvic cavity, with intrusion into the lumbar foramens. 18F-FDG PET/CT found a mass in the left retroperitoneum from the level of T12 to the left acetabulum, with the maximum standardized uptake value (SUVmax) of about 7.0, and a CT value of about 39 HU, invading the left L3-5 intervertebral foramina and protruding into the spinal canal, with unclear boundary with the spinal cord. Retroperitoneal tumor resection and the repair operation of vascular exploration were performed. An ARMS was confirmed by postoperative biopsy, immunohistochemical staining, and genetic detection with the rupture of the fork head in rhabdomyosarcoma (FKHR). The patient received chemotherapy and was in a good condition with no recurrence and obvious complications.ConclusionRetroperitoneal ARMS is rare and indicates a poor outcome with the potential to involve vital organs and intrude into the spinal canal. Accurate diagnosis and staging using PET/CT would contribute to better risk stratifications and appropriate treatment individually.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Retroperitoneal alveolar rhabdomyosarcoma intruding into spinal canal: A case report and literature review

Zhang

Huang

et al. 2022

Front. Med.

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“…(5) other bone metastases; (6) a history of spinal surgery; (7) other surgeries during follow-up; (8) other spinal diseases, diseases of the central nervous system, thyroid function disorder, and chronic renal or liver disease [14]; and (9) patients who were lost to follow-up. This study was approved by the ethics committee of Changzheng Hospital, and all patients or their families provided informed consent.…”

Section: Methodsmentioning

confidence: 99%

“…Once metastatic epidural spinal cord compression (MSCC) occurs, symptoms of severe pain, sensory and motor deficits, visceral dysfunction, and loss of ambulation appear, and quality of life (QoL) can be seriously affected [ 5 ]. To prevent disease deterioration, surgical treatments such as TES and PSRS are available to restore the physiological status and improve QoL [ 1 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Improvement of sleep quality in isolated metastatic patients with spinal cord compression after surgery

Cao

Xin

et al. 2023

World J Surg Onc

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Background This study aimed to assess changes in quality of sleep (QoS) in isolated metastatic patients with spinal cord compression following two different surgical treatments and identify potential contributing factors associated with QoS improvement. Methods We reviewed 49 patients with isolated spinal metastasis at our spinal tumor center between December 2017 and May 2021. Total en bloc spondylectomy (TES) and palliative surgery with postoperative stereotactic radiosurgery (PSRS) were performed on 26 and 23 patients, respectively. We employed univariate and multivariate analyses to identify the potential prognostic factors affecting QoS. Results The total Pittsburgh Sleep Quality Index (PSQI) score improved significantly 6 months after surgery. Univariate analysis indicated that age, pain worsening at night, decrease in visual analog scale (VAS), increase in Eastern Cooperative Oncology Group performance score (ECOG-PS), artificial implant in focus, and decrease in epidural spinal cord compression (ESCC) scale values were potential contributing factors for QoS. Multivariate analysis indicated that the ESCC scale score decreased as an independent prognostic factor. Conclusions Patients with spinal cord compression caused by the metastatic disease had significantly improved QoS after TES and PSRS treatment. Moreover, a decrease in ESCC scale value of > 1 was identified as a favorable contributing factor associated with PSQI improvement. In addition, TES and PSRS can prevent recurrence by achieving efficient local tumor control to improve indirect sleep. Accordingly, timely and effective surgical decompression and recurrence control are critical for improving sleep quality.

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“…Once metastatic epidural spinal cord compression (MSCC) occurs, symptoms of severe pain, sensory and motor de cits, visceral dysfunction, and loss of ambulation appear, and quality of life (QoL) can be seriously affected [5]. To prevent disease deterioration, surgical treatments such as TES and PSRS are available to restore the physiological status and improve QoL [1,6,7].…”

Section: Introductionmentioning

confidence: 99%

Improvement of Sleep Quality in Isolated Metastatic Patients with Spinal Cord Compression after Surgery

Cao

Xin

et al. 2022

Preprint

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Background This study aimed to assess changes in quality of sleep (QoS) in isolated metastatic patients with spinal cord compression following two different surgical treatments and identify potential contributing factors associated with QoS improvement. Methods We reviewed 49 patients with isolated spinal metastasis at our spinal tumor center between December 2017 and May 2021. Total en bloc spondylectomy (TES) and palliative surgery with postoperative stereotactic radiosurgery (PSRS) were performed on 26 and 23 patients, respectively. We employed univariate and multivariate analyses to identify the potential prognostic factors affecting QoS. Results The total Pittsburgh Sleep Quality Index (PSQI) score improved significantly six months after surgery. Univariate analysis indicated that age, pain worsening at night, decrease in visual analog scale (VAS), increase in Eastern Cooperative Oncology Group performance score (ECOG-PS), artificial implant in focus, and decrease in epidural spinal cord compression (ESCC) scale values were potential contributing factors for QoS. Multivariate analysis indicated that the ESCC scale score decreased as an independent prognostic factor. Conclusions Patients with spinal cord compression caused by the metastatic disease had significantly improved QoS after TES and PSRS treatment. Moreover, a decrease in ESCC scale value of > 1 was identified as a favorable contributing factor associated with PSQI improvement. In addition, TES and PSRS can prevent recurrence by achieving efficient local tumor control to improve indirect sleep. Accordingly, timely and effective surgical decompression and recurrence control are critical for improving sleep quality.

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Treatment strategies and outcomes for spinal rhabdomyosarcoma: A series of 11 cases in a single center and review of the literature

Cited by 8 publications

References 24 publications

Retroperitoneal alveolar rhabdomyosarcoma intruding into spinal canal: A case report and literature review

Retroperitoneal alveolar rhabdomyosarcoma intruding into spinal canal: A case report and literature review

Improvement of sleep quality in isolated metastatic patients with spinal cord compression after surgery

Improvement of Sleep Quality in Isolated Metastatic Patients with Spinal Cord Compression after Surgery

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