Treatment results of boron neutron capture therapy using intra-arterial administration of boron compounds for recurrent head and neck cancer

Abstract

The effect of boron neutron capture therapy (BNCT) is correlated with the density of boron in the tumour. BNCT using intra-arterial administration of boron compounds was performed for recurrent head and neck cancer. Of the five patients treated, one achieved a complete response and four achieved a partial response. There was one case of transient headache but no severe adverse effects were observed. The advantages of using an intra-arterial administration route for BNCT, which causes the selective killing of tumour cells, might offer a new option in the treatment of recurrent head and neck malignancies. These promising results require further verification and optimization of the BNCT schedule; however, dose escalation would appear to be justified because the toxicity appears to be very low.

Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial

“…Results from a few small series (11)(12)(13) and case reports (14,15) suggest that BNCT is effective in the treatment of locally recurrent head-and-neck cancer, and that most tumors respond to BNCT.…”

Novel Carborane Compounds Based on Cyclooxygenase‐2 Inhibitors for Effective Boron Neutron Capture Therapy of Tongue Squamous Cell Carcinoma

“…[16] BNCT is mainly used for the treatment of malignant brain tumors, malignant melanoma and head and neck cancers (HNC), especially for tumors that are difficult to treat by conventional methods such as surgical resection, chemotherapy and radiotherapy. [17][18][19][20][21][22] The cyclooxygenase-2 (COX-2), one of the two isoforms of COX, is usually rarely expressed inmost normal tissues but rapidly inducedunder pathological conditions suchas inflammation and cancers. [23] The expression of COX-2 has been reported to be increased in many cancers, including head and neck cancers.…”

Enhancing effect of ultrasound on boron concentrations in an oral squamous cell carcinoma cell line SAS for boron neutron capture therapy

“…Previous studies have shown that BNCT is an effective treatment for inoperable, locally recurrent head and neck cancer. Most patients who receive prior radiotherapy with X-rays or gamma rays respond to BNCT [6][7][8].…”