Treatment patterns for AL amyloidosis after frontline daratumumab, bortezomib, cyclophosphamide, and dexamethasone treatment failures

Zanwar, Saurabh; Gertz, Morie A.; Muchtar, Eli; Buadi, Francis K.; Kourelis, Taxiarchis; Gonsalves, Wilson; Go, Ronald S.; Hayman, Suzanne; Kapoor, Prashant; Binder, Moritz; Cook, Joselle; Dingli, David; Leung, Nelson; Lin, Yi; Warsame, Rahma; Fonder, Amie; Hobbs, Miriam; Hwa, Yi Lisa; Kyle, Robert A.; Rajkumar, S. Vincent; Kumar, Shaji; Dispenzieri, Angela

doi:10.1038/s41375-024-02243-5

Leukemia

2024

DOI: 10.1038/s41375-024-02243-5

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Treatment patterns for AL amyloidosis after frontline daratumumab, bortezomib, cyclophosphamide, and dexamethasone treatment failures

Saurabh Zanwar,

Morie A. Gertz,

Eli Muchtar

et al.

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2024

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Cited by 4 publications

(1 citation statement)

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“…This scenario was recently studied by the Mayo Clinic group. 9 They observed that trying to restore sensitivity to daratumumab with other medications such as carfilzomib, lenalidomide or pomalidomide does not meet with great success. Conversely, rescue with ASCT in eligible patients and with BCL2-inhibitors in subjects who harbour the translocation (11;14) seems more efficacious.…”

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confidence: 99%

Response matters in light chain amyloidosis, whatever it takes

Palladini,

Milani

2024

Br J Haematol

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Access to upfront daratumumab for AL amyloidosis is expanding, but it is not universal. Bomsztyk et al. show that patients who do not receive front‐line daratumumab can be effectively rescued with this agent, indicating that deep haematological response should be pursued tenaciously.Commentary on: Bomsztyk et al. Response rates to second‐line treatment with daratumumab bortezomib dexamethasone (DVD) in relapsed/refractory light chain (AL) amyloidosis after initial bortezomib‐based regime. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19529.

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confidence: 99%

Response matters in light chain amyloidosis, whatever it takes

Palladini,

Milani

2024

Br J Haematol

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Timing and outcomes of second‐line therapy in the era of daratumumab‐based frontline therapy in AL amyloidosis

Bazarbachi,

Bhutani,

Radhakrishnan

et al. 2024

American J Hematol

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Options for Rescue Treatment of Patients with AL Amyloidosis Exposed to Upfront Daratumumab

Bellofiore,

Palladini,

Milani

2024

Curr Oncol Rep

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Treatment patterns for AL amyloidosis after frontline daratumumab, bortezomib, cyclophosphamide, and dexamethasone treatment failures

Cited by 4 publications

References 15 publications

Response matters in light chain amyloidosis, whatever it takes

Response matters in light chain amyloidosis, whatever it takes

Timing and outcomes of second‐line therapy in the era of daratumumab‐based frontline therapy in AL amyloidosis

Options for Rescue Treatment of Patients with AL Amyloidosis Exposed to Upfront Daratumumab

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