Treatment outcomes of elderly salivary gland cancer patients undergoing radiotherapy – Results from a large multicenter analysis

Akbaba, Sati; Rühle, Alexander; Rothhaar, Sofie; Zamboglou, Constantinos; Gkika, Eleni; Forster, R. E.; Oebel, Laura; Klodt, Tristan; Schmidberger, Heinz; Grosu, Anca‐Ligia; Debus, Jürgen; Bostel, Tilman; Nicolay, Nils H.

doi:10.1016/j.radonc.2020.12.024

Cited by 8 publications

(2 citation statements)

References 51 publications

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“…Our research found that surgery plus radiotherapy was signi cantly associated with longer survival. Adjuvant radiotherapy improved the survival rate of cancer patients mainly by removing the possibility of partial residual and metastatic lesions 8, [33][34][35] . Recent ASCO guidelines also recommend adjuvant radiotherapy as a part of the therapeutic protocols for salivary gland malignancy 36 .…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a novel lymph node classification-based model for predicting survival in major salivary gland cancer

Shen

Gong

Cheng

et al. 2023

Preprint

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Background Current lymph node (LN) staging is controversial in predicting the survival of major salivary gland cancer (MSGC). Recently, a novel LN staging system for MSGC has been proposed. This study aimed to validate the prognostic value of the novel LN staging system and develop a new LN classification-based nomogram to predict the individualized overall survival (OS) of MSGC patients. Methods A total of 4563 MSGC patients were identified from the Surveillance Epidemiology and End Results (SEER) database (2004–2015). They were further randomly divided into the training and validation cohorts (7:3). OS was estimated by the Kaplan-Meier method, and prognostic factors were assessed using Cox proportional hazards model. Then, a prognostic nomogram predicting the survival of SGC was derived and validated. Finally, the discrimination and calibration of the nomogram were evaluated using C-index, the area under the time-dependent receiver operating characteristic curve (time-dependent AUC), and calibration plots. Decision curve analysis (DCA) was used to compare the clinical practicability between the nomogram and American Joint Committee on Cancer (AJCC) staging system. Results The novel LN staging system was found to be independently associated with OS in MSGC, and it exhibited better discriminatory ability than the current AJCC LN staging system. Meanwhile, a prognostic nomogram based on this staging was formulated. The C-index of the nomogram was 0.793 (95% CI: 0.781–0.805) in the training cohort, which was higher than the C-index of the AJCC staging system (0.707, 95% CI: 0.693–0.721, p < 0.001). And the time-dependent AUC (> 0.8) also indicated that the nomogram had a satisfactory discriminative ability. The calibration plots showed that the nomogram predicted was consistent with the actual observation. Additionally, DCA demonstrated that the nomogram had a better clinical application value than the AJCC staging system. Conclusions The novel SGC-specific LN staging system exhibited an excellent prognostic value for OS in patients with MSGC. And the proposed nomogram based on this LN staging showed better accuracy and applicability in predicting the OS of MSGC patients than the AJCC staging system.

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Section: Discussionmentioning

confidence: 99%

Development and validation of a novel lymph node classification-based model for predicting survival in major salivary gland cancer

Shen

Gong

Cheng

et al. 2023

Preprint

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“…A pooled data analysis of 288 elderly patients with SGCs treated at 3 institutions between 2005 and 2020 was recently performed: 207/288 subjects (72%) were treated with IMRT plus C12 boost, which was correlated with a high LRC (90.6% at 2 years), but the OS was not improved; 70/ 288 subjects (24.3%) experienced higher grade (G3) acute toxicities, most commonly mucositis, dysphagia and dermatitis. However, toxicities were not reported separately for particle and photon RT, and no structured evaluation of comorbidities was performed (131).…”

Section: Re-irradiation With Particle Therapymentioning

confidence: 99%

Salivary gland cancers in elderly patients: challenges and therapeutic strategies

Colombo

Lierde²,

Zlate³

et al. 2022

Front. Oncol.

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Salivary gland carcinomas (SGCs) are the most heterogeneous subgroup of head and neck malignant tumors, accounting for more than 20 subtypes. The median age of SGC diagnosis is expected to rise in the following decades, leading to crucial clinical challenges in geriatric oncology. Elderly patients, in comparison with patients aged below 65 years, are generally considered less amenable to receiving state-of-the-art curative treatments for localized disease, such as surgery and radiation/particle therapy. In the advanced setting, chemotherapy regimens are often dampened by the consideration of cardiovascular and renal comorbidities. Nevertheless, the elderly population encompasses a broad spectrum of functionalities. In the last decades, some screening tools (e.g. the G8 questionnaire) have been developed to identify those subjects who should receive a multidimensional geriatric assessment, to answer the question about the feasibility of complex treatments. In the present article, we discuss the most frequent SGC histologies diagnosed in the elderly population and the relative 5-years survival outcomes based on the most recent data from the Surveillance, Epidemiology, and End Results (SEER) Program. Moreover, we review the therapeutic strategies currently available for locoregionally advanced and metastatic disease, taking into account the recent advances in precision oncology. The synergy between the Multidisciplinary Tumor Board and the Geriatrician aims to shape the most appropriate treatment pathway for each elderly patient, focusing on global functionality instead of the sole chronological age.

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A novel postoperative nomogram and risk classification system for individualized estimation of survival among patients with parotid gland carcinoma after surgery

Zhu,

Gong,

Dai

et al. 2023

J Cancer Res Clin Oncol

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Treatment outcomes of elderly salivary gland cancer patients undergoing radiotherapy – Results from a large multicenter analysis

Cited by 8 publications

References 51 publications

Development and validation of a novel lymph node classification-based model for predicting survival in major salivary gland cancer

Development and validation of a novel lymph node classification-based model for predicting survival in major salivary gland cancer

Salivary gland cancers in elderly patients: challenges and therapeutic strategies

A novel postoperative nomogram and risk classification system for individualized estimation of survival among patients with parotid gland carcinoma after surgery

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