Treatment Outcomes of Alginate-Embedded Allogenic Mesenchymal Stem Cells Versus Autologous Chondrocytes for the Repair of Focal Articular Cartilage Defects in a Rabbit Model

Tay, Liang Xin; Ahmad, Raja Elina; Dashtdar, Havva; Tay, K W; Masjuddin, T.; Ab‐Rahim, Sharaniza; Chong, Pan Pan; Selvaratnam, Lakshmi; Kamarul, Tunku

doi:10.1177/0363546511420819

Cited by 80 publications

(39 citation statements)

References 52 publications

(76 reference statements)

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“…The encouraging results of MSCbased cartilage repair of full thickness cartilage defects in rabbit models reported by Shafiee et al 34 and Tay et al 35 led to similar use in clinical practices. Wakitani et al 36 reported a series of three cases of repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow MSCs.…”

Section: Resultsmentioning

confidence: 81%

Application of stem cells in orthopaedic conditions: what is the current evidence?

Tripathy¹,

Behera²,

Sen³

et al. 2013

OA Orthopaedics

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Section: Resultsmentioning

confidence: 81%

Application of stem cells in orthopaedic conditions: what is the current evidence?

Tripathy¹,

Behera²,

Sen³

et al. 2013

OA Orthopaedics

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“…Matrixassisted autologous chondrocyte transplantation leads to the synthesis of cartilage-like regeneration tissue and is clinically applicable 21 . The described animal model is well accepted in the experimental treatment of articular cartilage lesions 11,24,25 . However, the translation to clinical routine of possible results of experiments using the presented technique is difficult for several reasons.…”

Section: Discussionmentioning

confidence: 99%

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Berninger

Wexel

Rummeny

et al. 2013

JoVE

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Articular cartilage defects are considered a major health problem because articular cartilage has a limited capacity for self-regeneration 1 . Untreated cartilage lesions lead to ongoing pain, negatively affect the quality of life and predispose for osteoarthritis. During the last decades, several surgical techniques have been developed to treat such lesions. However, until now it was not possible to achieve a full repair in terms of covering the defect with hyaline articular cartilage or of providing satisfactory long-term recovery [2][3][4] . Therefore, articular cartilage injuries remain a prime target for regenerative techniques such as Tissue Engineering. In contrast to other surgical techniques, which often lead to the formation of fibrous or fibrocartilaginous tissue, Tissue Engineering aims at fully restoring the complex structure and properties of the original articular cartilage by using the chondrogenic potential of transplanted cells. Recent developments opened up promising possibilities for regenerative cartilage therapies. . In recent years, the implantation of autologous chondrocytes underwent a rapid progression. The use of an artificial three-dimensional collagen-matrix on which cells are subsequently replanted became more and more popular [7][8][9] . MACT comprises of two surgical procedures: First, in order to collect chondrocytes, a cartilage biopsy needs to be performed from a non weightbearing cartilage area of the knee joint. Then, chondrocytes are being extracted, purified and expanded to a sufficient cell number in vitro. Chondrocytes are then seeded onto a three-dimensional matrix and can subsequently be re-implanted. When preparing a tissue-engineered implant, proliferation rate and differentiation capacity are crucial for a successful tissue regeneration 10

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“…The predominant cell source was bone marrow, while other sources such as periosteum, synovium, placenta, and amnion have also been studied. Tay and associates compared applications of allogenic bone marrow-derived MSC with autologous chondrocyte application and demonstrated comparable efficacy in both groups implying the potential implication for the use of allogenic stem cells [23]. Various materials such as collagen [11,22], hyaluronic acid [14,17], polyglycolic acid [18], poly-(lactic-co-glycolic) acid [29,30], and silk fibroin [24] have been used as scaffolds; however, the superiority of one scaffold over another is as of yet unproven.…”

Section: Small Animal Studiesmentioning

confidence: 99%

Cartilage repair techniques in the knee: stem cell therapies

Yoshiya

Dhawan

2015

Curr Rev Musculoskelet Med

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Among the surgical options for large full-thickness chondral injuries, cell-based therapy has been practiced and its satisfactory outcomes have been reported. One area that appears promising is cell-based therapies utilizing stem cells. Various tissues within the human body contain mesenchymal stem cells (MSCs) from where these can be harvested. These include bone marrow, adipose, synovium, peripheral blood, and umbilical cord. In this article, both preclinical animal studies and clinical studies dealing with the use of MSCs for cartilage repair of the knee are reviewed. Majority of the clinical papers have shown promising results; however, there are a limited number of studies of high evidence level. Clinical significance of the stem cell therapy as compared to other surgical options as well as optimization of the procedure in terms of cell type and delivery method is still to be determined.

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Treatment Outcomes of Alginate-Embedded Allogenic Mesenchymal Stem Cells Versus Autologous Chondrocytes for the Repair of Focal Articular Cartilage Defects in a Rabbit Model

Abstract: The results have an implication of supporting the potential use of MSCs for cartilage repair after sports injuries or diseases, in view of similar efficacy but less patient morbidity and potential cost savings as compared with conventional autoC therapy.

Cited by 80 publications

References 52 publications

Application of stem cells in orthopaedic conditions: what is the current evidence?

Application of stem cells in orthopaedic conditions: what is the current evidence?

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Cartilage repair techniques in the knee: stem cell therapies

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