Treatment outcomes in malignant ovarian germ cell tumors

Kumar, B Ram

doi:10.18203/2320-1770.ijrcog20175089

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…In the present study, the overall survival rate was 77.77%. However, literature ( 32 – 35 ) supports a survival rate up to 90–95% after the introduction of cisplatin-based chemotherapy ( Table 1 ). Since MOGCTs are rare cancers, the studies conducted so far have limited sample size and have selection bias.…”

Section: Discussionmentioning

confidence: 99%

Unusual Cases of Pure Malignant Germ Cell Tumors of the Ovary: A Case Series on 10 Years Experience at a Tertiary Care Center

Goyal¹,

Kaur²,

Goyal³

et al. 2021

JRI

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Background: Malignant ovarian germ cell tumors (MOGCTs) are rare female cancers, constituting up to 10% of ovarian cancers. Dysgerminoma is the most common histological variant. Surgical removal of the tumor with optimal debulking is the treatment of choice. Multidrug chemotherapy following surgery offers high remission rates. Considering the prevalence of these tumors in adolescent and young females, fertility-sparing treatment is of paramount importance. Methods: The data of all patients with ovarian malignancy admitted at a tertiary-care-teaching hospital from September 2009-March 2019 were analyzed. Ten patients of MOGCTs were treated in this period. The clinical features, radiological and biochemical findings, and management and treatment outcome were evaluated. Results: The median age of patients was 23 years. Histological subtypes included immature teratoma (n=3), endodermal sinus tumor (n=4), and dysgerminoma (n=3). Tumor markers namely AFP, βHCG, and LDH increased in all except the patients with immature teratoma. Two patients with dysgerminoma were in the second trimester of pregnancy. All patients except one underwent surgery followed by BEP chemotherapy. Two patients had developed metastasis within six months of treatment and died. In seven patients, no evidence of disease was reported till date. Conclusion: Management of antenatal patients with dysgerminoma by surgery followed by BEP chemotherapy has favorable prognosis. Fertility-sparing surgery with adjuvant chemotherapy offers great advantage in young girls. However, risk stratification based on prognostic factors should be implemented in order to individualize the treatment for achieving higher survival rates. The option for oocyte-cryopreser-vation prior to surgery must be discussed with patients desiring future fertlity.

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Section: Discussionmentioning

confidence: 99%

Unusual Cases of Pure Malignant Germ Cell Tumors of the Ovary: A Case Series on 10 Years Experience at a Tertiary Care Center

Goyal¹,

Kaur²,

Goyal³

et al. 2021

JRI

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“…Histological type of ovarian cancer will affect the progression free survival and overall survival. Malignant ovarian germ cell tumor has the best prognosis because it is highly chemosensitive and is supported by an effective BEP chemotherapy regimen that allows for fertility conservation (39).…”

Section: F Histopathological Typementioning

confidence: 99%

Clinical Characteristics and Survival in Non-Epithelial Ovarian Cancer

Novitasari¹,

Tjokroprawiro²

2021

IJRP

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Ovarian cancer is often asymptomatic, grows rapidly and most diagnosed at advanced stage.Till now there is no method for early detection. Its incidence and mortality rate are increasing. Actually, non-epithelial type of ovarian cancer most found in young women and has better prognosis with adequate therapy. The main therapy for non-epithelial ovarian cancer is surgery, both radical and conservative (fertility sparing). Postoperative chemotherapy depends on the type and stage, although platinum-based chemotherapy regimens are used in almost all cases because of their chemosensitivity. The first-line regimens used are bleomycin, etoposide and cisplatin. Some clinical characteristics could affect prognosis including recurrence and survival rate. They include patient's age, cancer stage, tumor size, tumor marker, post-operative tumor residue, histopathological type of cancer, and chemotherapy. Better knowledge of those prognostic factor will lead to better management of patients with non-epithelial ovarian cancer and increase survival rate.

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Neoadjuvant Chemotherapy Versus Maximal Cytoreduction for Malignant Germ Cell Tumors of the Ovary

Agrawal

Podder

2022

Indian J Gynecol Oncolog

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Treatment outcomes in malignant ovarian germ cell tumors

Cited by 3 publications

References 18 publications

Unusual Cases of Pure Malignant Germ Cell Tumors of the Ovary: A Case Series on 10 Years Experience at a Tertiary Care Center

Unusual Cases of Pure Malignant Germ Cell Tumors of the Ovary: A Case Series on 10 Years Experience at a Tertiary Care Center

Clinical Characteristics and Survival in Non-Epithelial Ovarian Cancer

Neoadjuvant Chemotherapy Versus Maximal Cytoreduction for Malignant Germ Cell Tumors of the Ovary

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