Treatment Outcomes and Quality of Life in Oropharyngeal Cancer after Surgery-based versus Radiation-based Treatment

Kim, Tae Wook; Youm, Hye Youn; Byun, Hayoung; Son, Young Ik; Baek, Chung‐Hwan

doi:10.3342/ceo.2010.3.3.153

Cited by 21 publications

(24 citation statements)

References 28 publications

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“…11,13-14 To our knowledge the current study is the largest, prospective, longitudinal, single center study evaluating HRQOL profiles for patients who underwent TORS.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Transoral Robotic Surgery

Hurtuk

Agrawal

Old

et al. 2011

Otolaryngol.--head neck surg.

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Objective To report long-term, health-related quality of life (HRQOL) outcomes in patients treated with transoral robotic surgery (TORS). Study Design Prospective clinical study on functional and HRQOL outcomes in TORS. Setting University tertiary care facility. Subjects Patients who underwent TORS at The Ohio State University Medical Center. Methods All patients undergoing TORS were asked to complete the Head and Neck Cancer Inventory before treatment, and at 3 weeks, 3, 6, and 12 months postoperatively. Demographic, intraoperative, clinicopathological, and follow-up functional data were collected for each patient. Results Sixty four patients who underwent TORS were enrolled with a median age of 56.8years. A total of 113 TORS procedures were performed. Mean follow up time was 16.3 ± 7.49 months (range 6 to 33). Majority of TORS were performed for squamous cell carcinoma (88%). No patients experienced immediate postoperative complications, with all of the patients tolerating an oral diet without any airway compromise on the day of surgery. There was a decrease from baseline in the speech, eating, aesthetic, social, and overall QOL domains immediately after treatment. At the one year follow up, the HRQOL scores in the aesthetic, social, and overall QOL domains were near baseline. Patients with malignant lesions had significantly lower postoperative HRQOL scores in the speech, eating, social, and overall QOL domains (p<.05). Forty nine patients (77%) underwent adjuvant radiation therapy (RT), and 61% had chemoradiation (CRT) therapy. Patients who underwent adjuvant XRT or CRT had lower postoperative scores in the eating, social and overall QOL domains, compared to those who did not (p<.05). Conclusion TORS is a safe procedure with good functional and HRQOL outcomes. Patients who undergo TORS for malignancies and receive adjuvant therapy tend to have lower HRQOL outcomes. TORS is a promising future alternative surgical treatment for laryngopharyngeal tumors.

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“…11,13-14 To our knowledge the current study is the largest, prospective, longitudinal, single center study evaluating HRQOL profiles for patients who underwent TORS.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Transoral Robotic Surgery

Hurtuk

Agrawal

Old

et al. 2011

Otolaryngol.--head neck surg.

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“…However, mouth opening was not significantly different between surgery-based and RT-based treatment in a study by Kim et al who also used the EORTC QLQ-C30 and H&N35 [7, 43]. …”

Section: Discussionmentioning

confidence: 99%

Trismus following different treatment modalities for head and neck cancer: a systematic review of subjective measures

Loh

McLeod

Elhassan

2017

Eur Arch Otorhinolaryngol

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The aim of this review was to compare systematically the subjective measure of trismus between different interventions to treat head and neck cancer, particularly those of the oropharynx. Using The Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) Guidelines, Six databases were searched for the text using various terms which include “oropharyngeal/head and neck cancer”, “trismus/mouth opening” and the various treatment modalities. Included in the review were clinical studies (> or =10 patients). Three observers independently assessed the papers identified. Among the six studies reviewed, five showed a significantly worst outcome with regard to the quality-of-life questionnaire scores for a radiotherapy or surgery and radiotherapy (RT) ± chemotherapy or chemoradiotherapy when compared to surgery alone. Only one study showed no significant difference between surgery alone and other treatment modalities. Subjective quality-of-life measures are a concurrent part of modern surgical practice. Although subjective measures were utilised to measure post operative trismus successfully, there was no consensus as to which treatment modality had overall better outcomes, with conflicting studies in keeping with the current debate in this field. Larger and higher quality studies are needed to compare all three treatment modalities.

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“…None of the other symptom scales were affected by stage of disease. Kim et al (2010) evaluated 133 oropharyngeal cancer patients treated with surgery and radiotherapy, by means of EORTC QLO-C30 and HN65 questionnaires. In the group receiving radiation therapy, the symptom scores were high for dry mouth, difficulty in weight gain and the use of analgesics.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Quality of Life in Turkish Patients with Head and Neck Cancer

Akkaş¹,

Yücel²,

Kılıçkap³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: In this study, our aim was to investigate the effect of factors, such as radiotherapy, the dose of radiotherapy, the region of radiotherapy, the age of the patient, performance, co-morbidity, the stage of the disease and the therapy modalities on the quality of life of patients with head and neck cancer. Materials and Methods: Eighty-two patients who were treated by either chemoradiotherapy or radiotherapy, at the Cumhuriyet University Faculty of Medicine, Department of Radiation Oncology, between February 2007 and September 2010, for head and neck cancer were included. The quality of life European Organisation for Research and Treatment of Cancer, Questionnaire module to be used in Quality of Life assessments in Head and Neck Cancer (EORTC QLQ-H&N35) questionnaire was conducted in all patients before starting the radiotherapy, in the middle, at the end, at 1 month and at 6 months after the treatment. Results: According to the questionnaires at the end and at the 6 th month after the radiotherapy, it was found that the age of the patient, co-morbidity, ECOG performance state, localization, type of treatment, the stage of the disease, the dose and the region of radiotherapy affect some of the symptom scales for quality of life. Conclusions: Quality of life was affected negatively during and after the radiotherapy. However, in the 6 th month after the therapy, a significant improvement was observed in most symptoms.

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Treatment Outcomes and Quality of Life in Oropharyngeal Cancer after Surgery-based versus Radiation-based Treatment

Cited by 21 publications

References 28 publications

Outcomes of Transoral Robotic Surgery

Outcomes of Transoral Robotic Surgery

Trismus following different treatment modalities for head and neck cancer: a systematic review of subjective measures

Evaluation of Quality of Life in Turkish Patients with Head and Neck Cancer

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