Treatment Outcomes and Prognostic Factors in Children with Non-Hodgkin Lymphoma at a Single Institution

Kim, Ji Sook; Kong, Seom Gim; Oh, Chi Eun; Yoo, Ho; Park, Jae Sun

doi:10.15264/cpho.2014.21.2.86

Cited by 1 publication

(3 citation statements)

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“…Mean age was seven years as reported in the literature (6.2 + 2.8 years) 17. The most frequent site of presentation in most studies is abdomen which is also the case in our study 12,15,16. Burkitt’s lymphoma is the most common diagnosis in previous studies; our results confirm this finding.…”

Section: Discussionsupporting

confidence: 90%

“…General characteristics of our study population were the same as reported in the literature. Majority of our patients were male similar to other studies 12–16. Mean age was seven years as reported in the literature (6.2 + 2.8 years) 17.…”

Section: Discussionsupporting

confidence: 88%

“…Burkitt’s lymphoma is the most common diagnosis in previous studies; our results confirm this finding. Most patients presented with an advanced stage which is similar to data available 2,12,15,16. On multivariate analysis, we found sepsis, tumor lysis syndrome and malnutrition as significant.…”

Section: Discussionsupporting

confidence: 86%

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Malnutrition, Sepsis and Tumor Lysis Syndrome Are Associated With Increased Rate of Acute Mortality in Mature B Cell Non-Hodgkin Lymphoma in Pediatric Population- Study From Tertiary Care Hospital in Pakistan

Mansoor¹,

Saeed²,

Wali³

et al. 2019

Mediterr J Hematol Infect Dis

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Background: Outcomes of pediatric mature B cell NHL in resource challenged countries are negatively affected by increased rate of early and toxic deaths. Aim of this study is to assess rate of acute mortality and define significant risk factors present in children with mature B Cell NHL. Methods: A retrospective analysis was done of patients with B cell NHL from January 2012 till December 2016. Risk factors studied for acute mortality were malnutrition, stage, prior surgery with open laparotomy, LDH levels, tumor lysis syndrome, sepsis and fungal infection Results: Total 233 patients were enrolled in the study. Eighty five (36.4%) were below 15th percentile. Treatment was started in 226 patients. Eighty eight percent children showed 20% response after COP pre-phase. Tumor lysis syndrome was developed in 20.6 % (n = 48) children and 42.9% (n = 100) patients had sepsis, 71/100 patients had culture proven sepsis. 19.7% (n = 46) patients developed fungal infection. There was 19.7% (n = 46) acute mortality. Most common cause of death was sepsis (n = 22, 47.8%) followed by acute renal failure secondary to tumor lysis syndrome. On multivariate analysis, three independent variables found significant for early death are malnutrition, sepsis and tumor lysis syndrome. Conclusion: Rate of acute mortality in B cell NHL is high in our set up and significant risk factors are tumor lysis syndrome, sepsis and malnourishment at time of presentation.

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