“…We also suggest that resilience of psychological and physical health is best attained through integrative interventions that initiate change in multiple factors, resulting in substantial change that promotes health of the individual, as well as the social systems in which they reside, resulting in sustainable changes. Last, we assert that interventions at the physiological and cellular levels that reduce PTSD will also have lasting positive effects on families, communities, and society as a whole, which incurs the associated elevated medical costs (Marciniak et al, 2005;O'Donnell et al, 2005;Priebe et al, 2010;Walker et al, 2003), reduced employment productivity (Kimerling et al, 2009;Nandi et al, 2004), and parental and marital difficulties associated with PTSD (Fontana & Rosenheck, 2010;Gangi, Talamo, & Ferracuti, 2009;Kelley et al, 2010). In this article, we highlight the physiological and cellular factors that contribute to resilience and risk following trauma and describe how regulation of inflammation through these mechanisms results in resilience (see Tables 1 and 2).…”