Treatment outcomes according to endoscopic treatment modalities for rectal carcinoid tumors

Kim, Kwang Min; Eo, Sung June; Shim, Sang Goon; Choi, Ji Hun; Min, Byung‐Hoon; Lee, Jun Haeng; Chang, Dong Kyung; Kim, Young‐Ho; Rhee, Poong–Lyul; Kim, Jae J.; Rhee, Jong Chul; Kim, Jin Yong

doi:10.1016/j.clinre.2012.07.007

Cited by 59 publications

(72 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, only 1633/4575 (36%) had accurate staging recorded. 3 studies analysed a selected group of tumours up to the submucosa and are recorded in Table 3 but are not analysed [18][19][20]. 1260/1418 (89%) tumours were confined to the submucosa, 5% invaded the muscularis propria and 6% were beyond the muscularis propria.…”

Section: Resultsmentioning

confidence: 99%

“…With advances in endoscopic diagnosis of disease have come new treatment modalities, such as EMR, ESD and ESMR-L. There is limited data on the superiority of these endoscopic treatments but a small metaanalysis and some papers published do favour ESMR-L and ESD over EMR with higher clear resection margins for small tumours (<10mm) [13,20]. The recent metaanalysis by Zhong et al concluded that tumours up to 16mm operated with ESD had low recurrence rates and comparable complication rates with EMR [13].…”

Section: Discussionmentioning

confidence: 99%

“…The recent metaanalysis by Zhong et al concluded that tumours up to 16mm operated with ESD had low recurrence rates and comparable complication rates with EMR [13]. It has been previously published that tumours greater than 20mm should have radical surgery [33] and currently the literature regarding endoscopic management of rectal carcinoids does not detail any attempts in tumours greater than this size [13,[18][19][20].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Rectal carcinoids: a systematic review

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rectal carcinoids: a systematic review

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Endoscopic therapy in our study was largely endoscopic polypectomy or biopsy. Several recent studies have demonstrated the utility of endoscopic mucosal resection and even endoscopic submucosal dissection [26,27,28,32]. Results remain divided as to which endoscopic modality might have the best outcomes, with endoscopic mucosal resection having shorter procedure time and endoscopic submucosal dissection having a higher rate of complete resection [26].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Prognostic Features of Rectal Neuroendocrine Tumors

Weinstock¹,

Ward

Harpaz

et al. 2013

Neuroendocrinology

View full text Add to dashboard Cite

Background: Rectal neuroendocrine tumors (NETs) are among the most common NETs. The aim was to validate European Neuroendocrine Tumor Society (ENETS)/North American Neuroendocrine Tumor Society (NANETS) staging and grading systems with regard to clinical outcomes. Methods: A comprehensive database was constructed from existing databases of the Mount Sinai Division of Gastrointestinal Pathology and the Carcinoid Cancer Foundation. Analysis was performed on 141 patients identified with rectal NETs seen at Mount Sinai Hospital between 1972 and 2011. Results: The median age was 52.7 years; 43% were males. Average tumor size was 0.88 cm. NETs <1 cm accounted for 75.6% of the tumors. Stage I, II, III and IV accounted for 79.4, 2.8, 5.0 and 12.8% of the tumors, respectively. G1 tumors accounted for 88.1%, G2 8.3% and G3 3.6%. Of G1 tumors, 94.6% were stage I and 5.4% were stage IV. The median survival time for all 141 patients was 6.8 years (range, 0.8-34.7 years). The overall 5-year survival rate was 84.4%. The 5-year survival rates for patients in stages I-IV were 92.7, 75.0, 42.9 and 33.2%, respectively. The 5-year survival rates for patients with G1-G3 tumors were 87.7, 47.6 and 33.3%, respectively. Univariate analysis of increased survival showed significance for lower stage, lower grade, smaller size, absence of symptoms and endoscopically treated tumors. Multivariate analysis showed that stage alone was statistically significant as the strongest predictor of survival. Conclusion: The results of our study validated ENETS/NANETS guidelines for staging and grading of rectal NETs in the US setting of a tertiary referral center. Staging according to ENETS/NANETS guidelines should be used in the treatment algorithm rather than size alone.

show abstract

“…EMR with a ligation device (EMR-L) [5,6] and endoscopic submucosal dissection (ESD) [6] have been used to treat rectal NET and have been reported to be more useful than EMR [7,8]. On the other hand, the pocket creation method (PCM) was reported by Hayashi et al [9,10] as an ESD method for colon tumor, and has been described as a safe technique that offers a high en bloc resection rate compared with conventional colonic ESD [11].…”

Section: Introductionmentioning

confidence: 99%

Pocket Creation Method of Endoscopic Submucosal Dissection to Ensure Curative Resection of Rectal Neuroendocrine Tumors

Kobori

Katayama

Kitagawa

et al. 2018

GE Port J Gastroenterol

View full text Add to dashboard Cite

Purpose: Pancreatic/gastrointestinal tract neuroendocrine neoplasm (NEN) is divided into neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) according to the grade of malignancy, and differences are seen in clinical prognosis. NET, and rectal NET in particular, is often treated endoscopically. Endoscopic mucosal resection (EMR) was previously the main intervention for rectal NET, but EMR with a ligation device (EMR-L) and endoscopic submucosal dissection (ESD) are now also used. However, complete resection with these therapies is not always achieved. The pocket creation method (PCM) is a safe ESD method for colon tumors that offers a high en bloc resection rate compared with conventional colonic ESD. We performed ESD using the PCM for rectal NET and evaluated the complete resection rate. Methods: We performed ESD using the PCM in 4 patients. This procedure was technically feasible in all patients. Results: Endoscopically, all cases were resected en bloc, and pathological complete resection was achieved in all cases. No complications such as perforation or delayed postoperative bleeding were encountered. Conclusions: PCM should be considered when treating NET of appropriate size.

show abstract

Treatment outcomes according to endoscopic treatment modalities for rectal carcinoid tumors

Cited by 59 publications

References 26 publications

Rectal carcinoids: a systematic review

Rectal carcinoids: a systematic review

Clinical and Prognostic Features of Rectal Neuroendocrine Tumors

Pocket Creation Method of Endoscopic Submucosal Dissection to Ensure Curative Resection of Rectal Neuroendocrine Tumors

Contact Info

Product

Resources

About