Treatment outcome of tuberculosis among Saudi nationals: role of drug resistance and compliance

Samman, Yaseen S.; Krayem, Ayman; Haidar, Mauro Abi; Mimesh, Samara; Osoba, Abimbola O.; Al-Mowaallad, A.; Abdel‐Aziz, Marwa M.; Wali, Siraj

doi:10.1046/j.1469-0691.2003.00547.x

Cited by 31 publications

(25 citation statements)

References 7 publications

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“…The mean response size for nonSaudis (13.9 +/7 mm) was significantly larger than for Saudis (8.9 +/7 mm, p < 0.001). These data suggest that visitors and immigrants to Saudi Arabia are associated with a higher rate of tuberculosis dis- ease, which is in agreement with data from Europe [37]. Recent report by Ministry of Health showed that TB infection rate has risen again.…”

Section: Epidemiology Of Tb In Saudi Arabiasupporting

confidence: 89%

“…Despite the implementation of the NTP and DOTS, the number of patients effectively treated in Saudi Arabia has fallen below the WHO target of 85% with drug resistance, noncompliance and over the counter access to anti-tuberculosis treatment being contributing factors [5,15,37]. A retrospective study was conducted, which included 147 patients with culture proven diagnosis of tuberculosis seen at the King Khalid National Guard Hospital, Jeddah, between June 1993 and June 1999.…”

Section: National Tuberculosis Program (Ntp) and Directly Observed Thmentioning

confidence: 99%

“…One hundred and twenty-six patients completed treatment and, with patients lost to follow up considered as treatment failures, treatment success was 102/147 (69.4%) and failure 45/147 (30.6%). Noncompliance and drug resistance were cited as being significantly associated with treatment failures [37].…”

Section: National Tuberculosis Program (Ntp) and Directly Observed Thmentioning

confidence: 99%

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Tuberculosis in Saudi Arabia: Can we change the way we deal with the disease?

Al‐Hajoj

2010

Journal of Infection and Public Health

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Infection from Mycobacterium tuberculosis results in the death of three million people worldwide per annum of which an estimated one thousand are in Saudi Arabia. The WHO has set a target for successful treatment of 85% but Saudi Arabia is currently not meeting that target. We believe that the first step in improving the control of tuberculosis in Saudi Arabia is to improve and unify the standards of diagnostic services and laboratories responsible for tuberculosis. This paper reviews the current status and suggests possible improvements.

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Section: Epidemiology Of Tb In Saudi Arabiasupporting

confidence: 89%

Section: National Tuberculosis Program (Ntp) and Directly Observed Thmentioning

confidence: 99%

Section: National Tuberculosis Program (Ntp) and Directly Observed Thmentioning

confidence: 99%

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Tuberculosis in Saudi Arabia: Can we change the way we deal with the disease?

Al‐Hajoj

2010

Journal of Infection and Public Health

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“…The treatment outcome has never reached the 85% target set by the WHO, despite the implementation of DOTS in the early nineties. The treatment failure or default rate in the country was reported to be very high in previous studies, ranging from 13.23% to 30.6% [42,43]. However, recent nationwide published data is not available to assess the current status.…”

Section: Qualitative Researchmentioning

confidence: 99%

Tuberculosis in Saudi Arabia: the journey across time

Al‐Hajoj

Varghese

2015

J Infect Dev Ctries

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Saudi Arabia is the third-largest Arab country with a moderate annual burden of tuberculosis. However, tuberculosis (TB) is among several infectious diseases that have not been brought under control, despite the government's considerable efforts. This is clearly evidenced by the ongoing transmission of several imported and indigenous clades of Mycobacterium tuberculosis. In addition, the country faces the threat from rising proportions of extrapulmonary TB, non-tuberculous mycobacterial infections, and drug resistance. Furthermore, the country falls behind the global targets set by World Health Organization for the success rate of TB treatment. The country needs more population-based research studies, centralized and easily accessible clinical data registries, and centralized research and diagnostic facilities. This review focused on the trends of mycobacterial infections and on future proposals to improve TB control measures in Saudi Arabia.

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“…Although the TB incidence in Turkey has decreased by half since 1985, several studies have shown the proportion of drugresistant TB cases to be higher than the global average (3,5,10,11,20,24,26). In 2005, Surucuoglu and colleagues reported that the rate of resistance to any anti-TB drugs among 355 isolates of Mycobacterium tuberculosis obtained from western Turkey was 21.1%, while another study found that among the 1,513 TB cases diagnosed in Istanbul, Turkey, in 2005, 19% were resistant to at least one drug (20,25).…”

mentioning

confidence: 99%

Integration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug-Resistant Tuberculosis in Malatya, Turkey

et al. 2010

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Drug-resistant tuberculosis (TB) presents a major challenge to global TB control. To gain a better understanding of drug-resistant TB epidemiology in Malatya, Turkey, we conducted the present study using 397 Mycobacterium tuberculosis clinical isolates collected from Malatya, Turkey, in recent years (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007). Resistance to any anti-TB drug was found in 29% (114 of 397) of the study isolates, while the multidrug resistance (MDR) rate was ϳ4.5% (18 of 397). Resistances to isoniazid (15.5%) and streptomycin (13.4%) were about twice as high as resistance to rifampin (RMP) (6.3%) and ethambutol (EMB) (6.0%). Importantly, 28% (7 of 25) of the RMP-resistant isolates were non-MDR isolates, as when a significant proportion of RMPresistant isolates in a population are non-MDR, the predictive value of molecular detection of RMP resistance for MDR can be significantly reduced. Both identical and varied drug resistance patterns were seen in the same genotyping-defined clusters, suggesting that both primary and acquired resistance have contributed to the drug-resistant TB epidemic in Malatya, Turkey. In addition, drug-resistant cases were found to be more likely to be males (odds ratio [95% confidence interval], 1.82 [1.13, 2.94]), suggesting a potential role of gender in the epidemiology of drug-resistant TB in the study population. This study demonstrates that the integration of drug susceptibility testing with genotyping and epidemiological data analysis represents a useful approach to studying the epidemiology of drug-resistant TB.

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Treatment outcome of tuberculosis among Saudi nationals: role of drug resistance and compliance

Cited by 31 publications

References 7 publications

Tuberculosis in Saudi Arabia: Can we change the way we deal with the disease?

Tuberculosis in Saudi Arabia: Can we change the way we deal with the disease?

Tuberculosis in Saudi Arabia: the journey across time

Integration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug-Resistant Tuberculosis in Malatya, Turkey

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