Treatment outcome of new pulmonary tuberculosis in Guangzhou, China 1993–2002: a register-based cohort study

Abstract

BackgroundCompletion of treatment for tuberculosis (TB) is of utmost priority for TB control programs. The aims of this study were to evaluate the treatment outcome of TB cases registered in Guangzhou during the period 1993–2002, and to identify factors associated with treatment success.MethodsTwo (of eight) districts in Guangzhou were selected randomly as objects of study and their surveillance database was analyzed to assess the treatment outcome and identify factors associated with treatment success for TB cases registered in Guangzhou. Six treatment outcome criteria were assessed based on guidelines set by the World Health Organization (WHO). Logistic regression was used to estimate risk factors for treatment outcome.ResultsA total of 6743 pulmonary tuberculosis cases (4903 males, 1840 females) were included in this study. The treatment success rate (including cured and complete treatment) was 88% (95%CI 87%–89%). One hundred and eight-six (2.8%) patients died and 401 (5.9%) patients defaulted treatment. In multivariate analysis, treatment success was found to be associated with young age, lack of cavitation and compliance with treatment.ConclusionThe total treatment success rate in the current study was similar to the WHO target for all smear positive cases, while the failure rate and the default rate in 2002 were slightly higher. Good care of elderly patients, early diagnosis of cavitation and compliance with treatment could improve the success rate of TB treatment.

Factors Associated with Mortality in Tuberculosis Patients at Debre Birhan Referral Hospital, Ethiopia: A Retrospective Study

“…The treatment success rate of TB in this study was 64.6%, which is less than the 2017 WHO report, where the treatment success rate among 30 high TB burden countries varied from 71% to 94% [1] and the national report of overall treatment success rate in Ethiopia (83.7%) [19]. Moreover, the treatment success rate in the current study is still below the treatment success rate reported in Bahir Dar, Ethiopia, 80.8% [18], Tigray, Ethiopia, 89.2% [20] and China, 88% [12]. The low treatment success rate observed in this study might be due to a high death rate (16.5%) and transferred out rate (10.4%).…”

“…A study conducted in Gondar, Ethiopia showed that the treatment success rate of tuberculosis patients was unsatisfactorily low and it became a serious public health concern [11]. Being male, older age [12][13][14], smear-negative pulmonary or extrapulmonary tuberculosis and being rural resident was associated with lower treatment success rate [4,11]. Therefore, TB control programs should be strengthened to prevent unnecessary deaths [14].…”

Características clínicas, epidemiológicas y microbiológicas de una cohorte de pacientes con tuberculosis pulmonar en Cali, Colombia

“…El anterior hallazgo fortalece la idea de que la meta de curación de 85%, propuesta por la OMS, es posible en el contexto de la estrategia "Alto a la TB". Esto se ha evidenciado en otras cohortes que han registrado el aumento en las tasas de éxito terapéutico desde la implementación de la estrategia DOTS (24,25).…”

A Theoretical Assessment of the Effects of Smoking on the Transmission Dynamics of Tuberculosis

“…In Table 1, CSOZ means Central Statistics Office of Zimbabwe, a* denotes parameter values and ranges from Dye et al (1999), Dye and William (2000), b* denotes parameter values from , c* denotes parameter values from Qing-Song Bao et al (2007) and d* denotes parameter values from Bhunu et al (2008). Due to lack of data, the remaining parameters are assumed within realistic ranges (for the purpose of illustration) based on current understanding of the qualitative and synergistic relationships between smoking and TB and their essential biological and epidemiological features.…”