Abstract:SummaryThe purpose of this national retrospective study was to evaluate the outcome in children with relapsed or primary refractory Hodgkin lymphoma Other poor prognostic factors included advanced stage disease at relapse and B symptoms at first diagnosis. The most important factor associated with salvage failure was time to relapse. Survival outcome in children with primary refractory HL is poor.
“…However, the patients in our cohort were not the most favorable. Multiple studies have shown remission duration <1 year, presence of extranodal disease, and B symptoms at relapse to be important prognostic factors in relapsed/refractory HL . Likewise, a multivariate analysis of 606 children, adolescents, and young adults with relapsed or refractory HL (median age 23 years, range 3–29 years) who underwent ASCT demonstrated similar results .…”
Section: Discussionmentioning
confidence: 69%
“…The majority of published literatures in pediatric cohorts have employed computed tomography (CT) measurements to assess pretransplant disease status, and data on the predictive value of pretransplant FI in pediatrics are very limited. Based on the adult experience, the treatment approach at the Dana Farber/Boston Children's Cancer and Blood Disorders Center (DF/BC CBDC) has focused on getting patients with relapsed or refractory HL into complete metabolic remission before autologous transplant.…”
Background: Pretransplant functional imaging (FI), particularly a negative positron emission tomography (PET), is a strong predictor of outcome in adults with relapsed or refractory Hodgkin lymphoma (HL), but data in pediatrics are limited.
Methods:The medical records of 49 consecutive pediatric patients, who received autologous transplant at a single institution, were retrospectively analyzed. All patients had either gallium or PET scan before transplant and were conditioned with carmustine, etoposide, cytarabine, and melphalan (BEAM). Deauville scores were retrospectively assigned for patients with PET (score ≥ 4 positive).
Conclusion:Our analysis revealed outstanding outcomes for children and adolescents with relapsed/refractory HL. There were too few relapses to identify the predictive value of pretransplant metabolic status, but pediatric patients with relapsed/refractory HL and a negative pretransplant FI had excellent survival.
“…However, the patients in our cohort were not the most favorable. Multiple studies have shown remission duration <1 year, presence of extranodal disease, and B symptoms at relapse to be important prognostic factors in relapsed/refractory HL . Likewise, a multivariate analysis of 606 children, adolescents, and young adults with relapsed or refractory HL (median age 23 years, range 3–29 years) who underwent ASCT demonstrated similar results .…”
Section: Discussionmentioning
confidence: 69%
“…The majority of published literatures in pediatric cohorts have employed computed tomography (CT) measurements to assess pretransplant disease status, and data on the predictive value of pretransplant FI in pediatrics are very limited. Based on the adult experience, the treatment approach at the Dana Farber/Boston Children's Cancer and Blood Disorders Center (DF/BC CBDC) has focused on getting patients with relapsed or refractory HL into complete metabolic remission before autologous transplant.…”
Background: Pretransplant functional imaging (FI), particularly a negative positron emission tomography (PET), is a strong predictor of outcome in adults with relapsed or refractory Hodgkin lymphoma (HL), but data in pediatrics are limited.
Methods:The medical records of 49 consecutive pediatric patients, who received autologous transplant at a single institution, were retrospectively analyzed. All patients had either gallium or PET scan before transplant and were conditioned with carmustine, etoposide, cytarabine, and melphalan (BEAM). Deauville scores were retrospectively assigned for patients with PET (score ≥ 4 positive).
Conclusion:Our analysis revealed outstanding outcomes for children and adolescents with relapsed/refractory HL. There were too few relapses to identify the predictive value of pretransplant metabolic status, but pediatric patients with relapsed/refractory HL and a negative pretransplant FI had excellent survival.
“…transplantation and is used either as first line or salvage treatment [1][2][3][4]. The history of allogeneic HSCT goes back to the 1980 s and indications, conditioning regimens, and donor sources have changed enormously since then [5,6].…”
Section: Introductionmentioning
confidence: 99%
“…The Swiss Pediatric Oncology Group (SPOG) M. Ansari 6,7 , M. Beck Popovic 13 , J. P. Bourquin 14 , P. Brazzola 15 , J. Greiner 16 , J. Rössler 12 , F. Schilling 17 , K. Scheinemann 2,8,9 , N. von der Weid 4…”
Childhood cancer survivors treated with hematopoietic stem cell transplantation are at high risk for pulmonary morbidity and mortality. In this retrospective study we described transplant characteristics of pediatric patients who underwent hematopoietic stem cell transplantation in Switzerland and how these characteristics changed over time, compared self-reported pulmonary outcomes between transplanted and non-transplanted survivors, and investigated risk factors for the reported pulmonary outcomes. As part of the population-based Swiss Childhood Cancer Survivor Study, we sent questionnaires to all ≥5-year childhood cancer survivors diagnosed 1976–2010 at age ≤20 years. We included 132 transplanted survivors and 368 matched non-transplanted survivors. During the study period transplant characteristics changed, with decreasing use of total body irradiation and increased use of peripheral blood stem cells and mismatched and unrelated donors as transplant source. One-fifth of transplanted survivors (20%, 95%CI 13–27%) and 18% of non-transplanted survivors (95%CI 13–21%) reported at least one pulmonary outcome. None of the analyzed factors was significantly associated with an increased risk of pulmonary outcomes in multivariable analysis. We found that pulmonary outcomes were frequently reported in transplanted and non-transplanted childhood cancer survivors, indicating a strong need for long-term pulmonary follow-up care.
“…Several studies have suggested extrapolating data on the benefit of HDC and auto-SCT from the literature on adults. 4-7 The aim of this study was to evaluate the outcomes of children and adolescents with relapsed or refractory HL treated with HDC and auto-SCT at our institution. In a resource-limited setting such as ours, outcomes were analyzed in progressive HL to decide whether to continue to offer this mode of therapy to patients.…”
PURPOSE Hodgkin lymphoma is the most common cancer in children, adolescents, and young adults. Overall survival is approximately 80% to 90%. A subset of these patients has refractory disease or experience disease relapse. Conventional salvage therapies and autologous stem-cell transplantation is usually considered the standard of care for these patients. Our analysis reports outcomes in these patients. PATIENTS AND METHODS After institutional review board approval, a retrospective analysis of patients with Hodgkin lymphoma who were up to 18 years of age and who had refractory or relapsed disease at Shaukat Khanum Memorial Cancer Hospital and Research Centre from September 2009 to December 2013 was performed. Patients who underwent high-dose chemotherapy followed by stem-cell rescue were included in this analysis. RESULTS A total of 567 patients with Hodgkin lymphoma registered at the hospital. Sixty of the patients (10.6%) had either primary progressive or refractory disease or relapse after finishing with first-line chemotherapy. High-dose chemotherapy followed by stem cell was administered to 25 of these patients (42%). Thirteen patients (40%) had progressive disease (PD), five (22%) had early relapse, and seven (38%) had late relapse. A number of salvage regimens were used, including etoposide, prednisolone, ifosfamide, and cisplatin; dexamethasone, cytarabine, and carboplatin; and gemcitabine plus vinorelbine. Re-evaluation was performed before taking patients to a high dose, and it showed complete response in 17 patients (68%), partial response in six patients (24%), and PD in two patients (8%). Twenty-one patients (84%) are in remission after transplantation, with two patients (8%) having died as a result of disease progression and two patients (2%) having relapsed after treatment. Overall survival is 92% at 4 years, with event-free survival of 80% at 4 years. CONCLUSION Our retrospective analysis shows good outcomes in patients who had PD or refractory disease. Disease response before transplantation is important in predicting outcomes.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.