Treatment outcome and its predictors among <scp>A</scp>sian problem drinkers

Manning, Victoria; Gomez, Brenda; Koh, Puay Kee; Ng, Andrew Y.; Guo, Song Ling; Kandasami, Gomathinayagam; Wong, KokSheik

doi:10.1111/j.1465-3362.2012.00518.x

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…Instead outcome measures such as days with heavy drinking, defined as consumption of certain levels of alcohol in a 30-day period, have been used to define relapse (Soyka and Schmidt, 2009;Manning et al, 2013;Mellentin et al, 2018), yet the definition of controlled drinking as a successful treatment goal may vary between patients and misestimations of alcohol quantities among study participants have been shown to result in overestimations of treatment efficiency and underestimation of relapse (Kirouac et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Predictors of Readmission Following Outpatient Treatment for Alcohol Use Disorder

Hansen

Mejldal

Nielsen

2020

Alcohol and Alcoholism

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Aims To identify predictors of readmission to outpatient treatment for alcohol use disorder (AUD) with a view to identifying underlying mechanisms for preventing relapse. Methods A consecutive clinical cohort of 2130 AUD outpatients treated between 1 January 2006 and 1 June 2016 was studied. Data were collected by means of the Addiction Severity Index upon treatment entry and at discharge. Outcome measures were readmission to outpatient treatment and time to readmission. Potential predictors were tested for significance using Cox Proportional Hazards multivariate analysis. Results A total of 22% were readmitted during the follow-up time. Patients readmitted within 1 year of treatment conclusion differed significantly from those not readmitted on age, cohabitation status and completion status of index treatment. Significant predictors of readmission during follow-up time were younger age (hazard ratio (HR) = 0.99, 95% confidence interval (CI), 0.98–1.00), history of psychiatric illness (HR = 1.24, 95% CI, 1.02–1.50), drop-out from index treatment (HR = 1.41, 95% CI, 1.15–1.72) and length of index treatment (HR = 1.02, 95% CI, 1.00–1.04). Conclusion Premature drop-out from treatment, a history of psychiatric illness, younger age and longer treatment episodes appear to be the most important predictors of readmission.

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Section: Introductionmentioning

confidence: 99%

Predictors of Readmission Following Outpatient Treatment for Alcohol Use Disorder

Hansen

Mejldal

Nielsen

2020

Alcohol and Alcoholism

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“…As our dataset is small, it may not be representative; however, the ethnic profile of the subjects recruited (Table 1) reflects previous reports. Past studies suggest that the majority of the AUD cases had either Chinese or Indian background [49], while Malay, followed by subjects of Chinese ethnicity, made up the bulk of OUD cases. Future studies should focus on ethnic differences in genetic variations in specific substance types.…”

Section: Discussionmentioning

confidence: 99%

Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot Feasibility Study

Asharani

Amron

Zainuldin

et al. 2021

JCM

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Genetics intersects with environmental, cultural, and social factors in the development of addictive disorders. This study reports the feasibility of whole-exome sequencing of trios (subject and two family members) to discover potential genetic variants in the development of substance use disorders (SUD). Family trios were recruited from the National Addictions Management Service in Singapore during the 2016–2018 period. Recruited subjects had severe alcohol use disorder (AUD) or opioid use disorder (OUD), with nicotine dependence (ND) and a family history of addictive disorders. Demographic characteristics and severity of addiction were captured. Whole-exome sequencing (WES) and analysis were performed on salivary samples collected from the trios. WES revealed variants in several genes in each individual and disruptive protein mutations in most. Variants were identified in genes previously associated with SUDs, such as Pleckstrin homology domain-containing family M member 3 (PLEKHM3), coiled-coil serine-rich protein 1 (CCSER1), LIM and calponin homology domains-containing protein 1 (LIMCH1), dynein axonemal heavy chain 8 (DNAH8), and the taste receptor type 2 member 38 (TAS2R38) involved in the perception of bitterness. The feasibility study suggests that subjects with a severe addiction profile, polysubstance use, and family history of addiction may often harbor gene variants that may predispose them to SUDs. This study could serve as a model for future precision medicine-based personalized interventional strategies for behavioral addictions and SUDs and for the discovery of potentially pathogenic genetic variants.

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“…According to second theme, the main components recommended for substance abuse rehabilitation according to the research result are as follows: addict’s acceptance of the treatment and taking responsibility of the treatment regarding substance addiction, attendance of family especially father during rehabilitation process, together with health-care support, the implementation of family-based psychological support, commitment to continuous and sustainable fight against addiction, strengthening problem-solving and cognitive skills of the addict, forming a new social life, return to work or school life, reshaping family relationships, reconstruction of family bonds, and feeling of belonging. Manning et al (2013) state that fight against alcohol and substance addiction is a lifelong process, and it is necessary to give psychological support to family members since family is the most important source of support for addicts during this process. Related literature shows that medical treatment given in health facilities is not alone sufficient to provide a long-term solution, and psychological and social support should be given to addicts with the inclusion of parents into the rehabilitation process (Kim, Kwok, Mayes, Potenza, Rutherford, & Strathearn, 2017).…”

Section: Discussionmentioning

confidence: 99%

Inclusion of Family Therapy in Rehabilitation Program of Substance Abuse and Its Efficacious Implementation

Ulaş

Ekşi

2019

The Family Journal

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The family has been described as the center or heart of societal relationships. There has been a historic neglect of research in area of counseling for the family members of substance abusers. As result, treatment for individual family members affected by alcoholism and drug addiction remains a neglected component of majority of addiction programs. The study used a sample of 36 families who participated in family therapy intensive outpatient and inpatient treatment program during 2 years. This study explored the efficacy of family-based treatment in changing family’s attitudes toward people with addiction and toward specific relative with addiction. The participants were in two groups; ethnographic technique of action research model was used. Participants in the treatment group received treatment session and participants in the control group did not receive treatment session but had a general treatment program in health centers. This study had two phases: (1) recruiting, selecting, interviewing, and determining eligibility of family members from both groups in the study and (2) applying the intervention to the treatment group with the help of cognitive-behavioral group counseling. This treatment program comprised of solution-focused family skilled training therapy, action learning techniques, community and peer mentorship, and parent training was effective in reducing addicts drug ingestion, changing their attitudes about drug use, increasing knowledge of the physical consequences of drug use, and improving competent behaviors. Family therapy enhanced family resilience, structure, and strong ties; the program improved problem-solving skills, coping skills, and family resiliency levels of the addicts.

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Treatment outcome and its predictors among Asian problem drinkers

Cited by 5 publications

References 41 publications

Predictors of Readmission Following Outpatient Treatment for Alcohol Use Disorder

Predictors of Readmission Following Outpatient Treatment for Alcohol Use Disorder

Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot Feasibility Study

Inclusion of Family Therapy in Rehabilitation Program of Substance Abuse and Its Efficacious Implementation

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