Treatment of vulvar/vaginal condyloma by HPV: developed instrumentation and clinical report

Inada, Natália Mayumi; Kurachi, Cristina; Ferreira, Juliana; Ribeiro, Elyse Soares; Guimarães, O.C.C.; Quintana, Silvana Maria; Lombardi, Wellington; Bagnato, Vanderlei Salvador

doi:10.1117/12.823034

Cited by 4 publications

(2 citation statements)

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“…[1][2][3][4] In recent years, PDT has achieved rapid progress both in fundamental research [5][6][7][8] and clinic practice, [9][10][11] which makes it become the fourth minimal invasive therapy for cancer treatment following surgery, radiotherapy and chemotherapy. 12 PDT is based on the principle that light-activated photosensitizer can produce lethal cytotoxic active singlet oxygen ( 1 O 2 ) and other reactive oxygen species (ROS) to damage tumors and their surrounding vasculature when the tumor tissues uptaking the photosensitizer are irradiated with a specific wavelength light in the presence of tissue oxygen.…”

Section: Introductionmentioning

confidence: 99%

Magnetic and pH dual-responsive mesoporous silica nanocomposites for effective and low-toxic photodynamic therapy

Zhan¹,

Ma²,

Wang³

et al. 2017

IJN

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Nonspecific targeting, large doses and phototoxicity severely hamper the clinical effect of photodynamic therapy (PDT). In this work, superparamagnetic Fe 3 O 4 mesoporous silica nanoparticles grafted by pH-responsive block polymer polyethylene glycol- b -poly(aspartic acid) (PEG- b -PAsp) were fabricated to load the model photosensitizer rose bengal (RB) in the aim of enhancing the efficiency of PDT. Compared to free RB, the nanocomposites (polyethylene glycol- b -polyaspartate-modified rose bengal-loaded magnetic mesoporous silica [RB−MMSNs]) could greatly enhance the cellular uptake due to their effective endocytosis by mouse melanoma B16 cell and exhibited higher induced apoptosis although with little dark toxicity. RB−MMSNs had little dark toxicity and even much could be facilitated by magnetic field in vitro. RB−MMSNs demonstrated 10 times induced apoptosis efficiency than that of free RB at the same RB concentration, both by cell counting kit-8 (CCK-8) result and apoptosis detection. Furthermore, RB−MMSNs-mediated PDT in vivo on tumor-bearing mice showed steady physical targeting of RB−MMSNs to the tumor site; tumor volumes were significantly reduced in the magnetic field with green light irradiation. More importantly, the survival time of tumor-bearing mice treated with RB−MMSNs was much prolonged. Henceforth, polyethylene glycol- b -polyaspartate-modified magnetic mesoporous silica (MMSNs) probably have great potential in clinical cancer photodynamic treatment because of their effective and low-toxic performance as photosensitizers’ vesicles.

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Section: Introductionmentioning

confidence: 99%

Magnetic and pH dual-responsive mesoporous silica nanocomposites for effective and low-toxic photodynamic therapy

Zhan¹,

Ma²,

Wang³

et al. 2017

IJN

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show abstract

“…Among these, due to the localized PDT treatment, the most common application is the treatment of different manifestations of HPV, 24a,224,231,232,233,234 e.g., acral 233,235,236,237,238,239,240,241,242 and facial 243,244,245 warts or warts in the genital region (Condylomata acuminata). 219,246,247,248,249,250,251,252,253,254,255,256,257 In addition, antiviral PDT has been of interest in the treatment of recurrent respiratory papillomatosis. 248 Apart from treatment, ALA can of course also be employed in the fluorescence diagnosis of HPV infections.…”

Section: Naturally Derived Porphyrins -Ala and Haematoporphyrinmentioning

confidence: 99%