Treatment of vulvar intraepithelial neoplasia with topical imiquimod: Seven years median follow-up of a randomized clinical trial

Abstract

In case of a complete response, imiquimod is effective in the long-term. Furthermore, patients with a long-term complete response had a significantly better global quality of life than patients who recurred after imiquimod treatment.

Clinical Characteristics Associated With Development of Recurrence and Progression in Usual-Type Vulvar Intraepithelial Neoplasia

“…24 Recurrences after imiquimod are established at approximately 20.5% versus 53.5% after surgical therapies. 35,36 The small number of patients treated with imiquimod in our group, however, show comparable results to excision regarding RFS in univariate analyses (Fig. 1).…”

Vulvar intraepithelial neoplasia

“…In the largest prospective, randomized, double-blinded, and placebo-controlled study [62] with 52 patients, a 35% complete response and 46% partial response was found. After a median follow-up of 7.2 years, VIN recurred in only one of the complete respondents, suggesting that imiquimod is effective in the long term [63].…”

Traitement des néoplasies vulvaires intra-épithéliales par imiquimod

“…En 2011, Terlou et al ont publié les ré sultats de suivi à 7 ans des patientes traité es par imiquimod dans la cohorte de van Seters [16]. Parmi les 26 patientes initialement traité es par imiquimod, 24 ont pu être ré é valué es à 7 ans et 2 patientes non revues ont pu donner les informations né cessaires sur l'é volution de leur maladie.…”