Treatment of vocal cord paralysis by autologous fat injection: Our experience with 41 patients

Tran, Hong V.; Tran-Le, Phuc T.; Nguyen, Tuan V.

doi:10.1111/coa.13230

Cited by 6 publications

(25 citation statements)

References 12 publications

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“…32 Also, ours is the third largest study in sample size, among those published since 2016, in which liposuction fat grafts were used. 5-26,30,32…”

Section: Discussionmentioning

confidence: 99%

“…These results are coincident with the ones published in scientific literature, where scarred vocal folds show a higher chance to require a second procedure than nonscarred vocal folds. 9-14,32…”

Section: Discussionmentioning

confidence: 99%

“…These good results coincide with reports published in the most recent studies (since 2016) in which fat grafts obtained through liposuction were used. [9][10][11][12][13][14][15]17,23,30,32 However, our series is the second largest in the literature in the number of patients with glottic insufficiency caused by scarred vocal folds, as most of the studies performed on autologous fat injection laryngoplasty are focused on the treatment of unilateral vocal fold paralysis. 32 Also, ours is the third largest study in sample size, among those published since 2016, in which liposuction fat grafts were used.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, no other study has reported the use of lipoaspirate processed through centrifugation and emulsification, and until 2016, none had reported the use of centrifuged fat grafts. 5-26 Centrifugation of the fat graft allows one to obtain a more concentrated tissue, and the process of emulsification reduces the size of fat particles in the graft. 27 This combination of fat-processing techniques has never been reported before for vocal fold augmentation.…”

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confidence: 99%

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Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts

Salmerón‐González

García‐Vilariño

Llópez-Carratalá

et al. 2020

Otolaryngol.--head neck surg.

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Objective To review the results of a series of patients with glottic insufficiency caused by scarred vocal folds who underwent injection laryngoplasty with centrifuged and emulsified autologous fat. Study Design Prospective cohort. Setting Single center, tertiary institution. Subjects and Methods Examination of the medical records of 21 patients operated on through injection laryngoplasty with fat grafts for the treatment of dysphonia was performed. All patients were operated on between January of 2015 and September of 2019. The voice variables measured were the GRABS (Grade, Roughness, Breathiness, Asthenia, Strain) scale, the Voice Handicap Index–10 (VHI-10), maximum phonation time, jitter, shimmer, and harmonic/noise ratio before surgery and 8 months later. Results Twenty-six injection laryngoplasties were performed in 21 patients during the reviewed period. Seventeen were men, and 4 were women. Mean age was 57.2 (range, 18-80) years. Mean (SD) follow-up time was 20.7 (9.3) months. Etiology of dysphonia was scarring after tumor resection in 17 patients and sulcus vocalis in 4. Five patients received an additional injection laryngoplasty. Statistically significant improvements were observed in all the parameters evaluated ( P < .05). Conclusions Injection laryngoplasty with fat grafts processed through centrifugation and emulsification is an effective technique for the treatment of dysphonia caused by glottic insufficiency related to scarred vocal folds, with minimal complication rates.

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“…32 Also, ours is the third largest study in sample size, among those published since 2016, in which liposuction fat grafts were used. 5-26,30,32…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts

Salmerón‐González

García‐Vilariño

Llópez-Carratalá

et al. 2020

Otolaryngol.--head neck surg.

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“…8,9 There are reports of the utility of nerve monitoring to create a more selective upper-airway stimulation system by separating the inclusion and exclusion branches. 5,10 Neuromonitoring leads…”

Section: Post-implant Subjective Characteristicsmentioning

confidence: 99%

Improved exposure of the hypoglossal branches during hypoglossal nerve stimulator implantation: Clinical outcomes of twenty patients at a single institution

Weidenbecher

Tamaki

Cabrera

2018

Clinical Otolaryngology

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Autologous Lipoaugmentation Long‐Term Clinical Outcomes: A Systematic Review

et al. 2021

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Objectives/Hypothesis Vocal fold (VF) lipoaugmentation can be employed to treat glottal insufficiency although variable data exist on its length of effectiveness. We aimed to review published long‐term outcomes following lipoaugmentation across the literature and compile outcome data. Study Design Systematic review. Methods A systematic search in September 2020 of PubMed, MEDLINE, Cochrane Library, and Web of Science used the Preferred Reporting Items for Systematic Review and Meta‐Analyses guidelines to identify 128 relevant articles related to VF lipoaugmentation effectiveness duration. Primary search terms included the following: vocal cord, fat, lipo, and atrophy. Forty‐eight full‐text articles were reviewed and 31 were included in the final analysis. Primary endpoints included the following: duration of effectiveness per patient‐reported outcome measures, objective findings, and additional procedures performed. In addition, fat harvest location and processing techniques were recorded. Findings Thirty‐one studies totaling 764 patients were included in the review. Indications for augmentation were VF paralysis (N = 690) and atrophy (N = 74). Fat was harvested from the abdominal region in 21 studies (529 patients), the thigh/abdomen in 5 studies (91 patients), and buccal/submental region in 2 studies (33 patients). Processing techniques and injectable volume varied. Across included studies, only 11 of 764 patients (1.4%) reported no improvement in voice and/or swallowing. Within the first year, 71 of 608 patients (11.7%) reported a regression toward baseline. Beyond 1 year and up to 8 years, 27 of 214 patients (12.6%) reported regression from initial improvement. Thirty‐three patients underwent additional procedures. Conclusion Although improvements in voice and swallowing after lipoaugmentation taper over time, most patients experienced long‐term benefit. Laryngoscope, 132:1042–1053, 2022

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Treatment of vocal cord paralysis by autologous fat injection: Our experience with 41 patients

Cited by 6 publications

References 12 publications

Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts

Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts

Improved exposure of the hypoglossal branches during hypoglossal nerve stimulator implantation: Clinical outcomes of twenty patients at a single institution

Autologous Lipoaugmentation Long‐Term Clinical Outcomes: A Systematic Review

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