Treatment of vitiligo with 308‐nm excimer laser: our experience from a 2‐year follow‐up of 979 Chinese patients

Fa, Yuecel; Lin, Yan; Chi, Xiaoli; Shi, Wenhao; Wang, J.L.; Guo, Xiaohan; Geng, Jianhui; Liu, H.X.; Zhang, F.R.

doi:10.1111/jdv.13917

Cited by 21 publications

(19 citation statements)

References 11 publications

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“…However, the reaction to therapy depends mainly on the site of the body . The excellent response was observed on the face in retrospective research of 979 patients by Fa et al (>75% repigmentation: 40.86%), whereas the hands and feet showed the poorest response (>75% repigmentation: 9.17%).…”

Section: Discussionmentioning

confidence: 97%

“…If symptomatic erythema (burning, pain) or blistering advanced therapy was stopped until resolution, then the dose was reduced by 50 mJ/cm2.7 During therapy, only the diseased parts were exposed, and UV‐blocking goggles shielded the eyes. If there was important depigmentation on the eyelids, and if patients insisted on treating these regions, patients were advised to maintain their eyes closed during therapy, and all patients were told to use daytime sunscreens …”

Section: Methodsmentioning

confidence: 99%

“…If there was important depigmentation on the eyelids, and if patients insisted on treating these regions, patients were advised to maintain their eyes closed during therapy, and all patients were told to use daytime sunscreens. 15…”

Section: Settings Of the Excimer Lasermentioning

confidence: 99%

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Evaluation of combined excimer laser and platelet‐rich plasma for the treatment of nonsegmental vitiligo: A prospective comparative study

Khattab

Abdelbary

Fawzi

2019

J of Cosmetic Dermatology

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Background Excimer laser therapy of vitiligo generally takes months to years to achieve excellent outcomes. Platelet‐rich plasma is an autologous preparation with a focus on various growth factors that can help with vitiligo repigmentation. Objectives To assess the additive effect of PRP in the therapy of vitiligo on the results of the excimer laser. Patients and Methods A comparative study included 52 patients (8 males and 44 females) in two groups with stable (no new lesion for 6 months), nonsegmental and symmetrical vitiligo. Group I (26 patients): The patient was treated by intradermal PRP injection and the excimer laser, while group II (26 patients) was treated with the excimer laser only. The PRP injection was repeated every 3 weeks for 4 months and excimer laser two times a week and for 16 weeks till complete response. VAS for patient's satisfaction assessment, safety assessment for complications, and follow‐up for 3 months was done. Clinical (repigmentation response) and histopathological assessment was done. Results There was a higher statistically significant treatment response in group I compared with group II. In addition, a statistically significant correlation between the treatment response and the lesion site in group I (P < .000). A significant difference in VAS between both groups (P < .000). Few the side effects were reported. Conclusion The combination of PRP and excimer laser phototherapy is an efficient vitiligo treatment as PRP increases the excimer laser impact and also improves the result.

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Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

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Evaluation of combined excimer laser and platelet‐rich plasma for the treatment of nonsegmental vitiligo: A prospective comparative study

Khattab

Abdelbary

Fawzi

2019

J of Cosmetic Dermatology

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“…The xenon chloride excimer (308 nm) laser or light can effectively deliver higher doses of UVB to depigmented patches without damage to the surrounding skin. Mild‐to‐severe erythema is the major side effect of excimer devices …”

Section: Introductionmentioning

confidence: 99%

“…Mildto-severe erythema is the major side effect of excimer devices. [5][6][7][8] While phototherapy is an effective treatment modality for vitiligo, a portion of patients are slow responders, requiring up to 72 treatments before notable repigmentation has been achieved. 4 In addition, up to one-third of patients with vitiligo do not photoadapt, meaning they do not exhibit a diminished erythema response to equivalent doses of NBUVB upon subsequent irradiation.…”

Section: Introductionmentioning

confidence: 99%

Effect of combination NSAID and NBUVB treatment in non‐photoadapters—A pilot study

Mehta

Mohammad

Mehta

et al. 2019

Photoderm Photoimm Photomed

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Background Vitiligo is a disorder of dyspigmentation that can impact quality of life. While narrow‐band ultraviolet B (NBUVB) is an effective treatment for vitiligo, a subset of patients are unable to respond to phototherapy as they cannot photoadapt. However, nonsteroidal anti‐inflammatory drugs (NSAIDs) have been shown to increase the minimal erythema dose. Purpose To determine whether ibuprofen allows non‐photoadapters to respond to therapeutic doses of NBUVB and maintain photoadaptation. Method Four patients unable to tolerate NBUVB or excimer past a dose of 1000 mJ/cm2 were enrolled in the study and given ibuprofen 400 mg prior to phototherapy, which was performed 2‐3 times a week. Patients were followed up to 72 treatments to demonstrate photoadaptation and maintenance of response to phototherapy. Patients were clinically monitored by serial photographs approximately every 12 treatments. Response to phototherapy was monitored by tracking the dose of NBUVB received at each session. Maintenance of response was monitored for six treatments after discontinuing the ibuprofen. Percent change in pigmentation was also recorded. Results Three out of four subjects enrolled in the study were able to increase their doses of phototherapy to a therapeutic range, and subjects continued to photoadapt for six treatments after discontinuing ibuprofen. Two subjects achieved repigmentation during their course of phototherapy. Conclusion Ibuprofen may be a safe alternative to corticosteroids for select patients with vitiligo that are unable to photoadapt. It appears that the ability to photoadapt continues once ibuprofen is discontinued, negating the need for chronic use. Enabling photoadaptation allows patients to achieve therapeutic doses of NBUVB phototherapy, leading to repigmentation and improved outcomes. Trial Registration The trial was registered through Henry Ford Hospital IRB—No. 9744.

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Phototherapy in Pigmentary Disorders

Theng¹,

Tan

2018

Pigmentary Skin Disorders

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Treatment of vitiligo with 308‐nm excimer laser: our experience from a 2‐year follow‐up of 979 Chinese patients

Abstract: 308-nm excimer laser appears to be an effective and safe treatment in Chinese vitiligo patients. The clinical response and treatment efficacy was affected by many factors such as age, affected anatomical area, shape of the lesion, disease duration and treatment frequencies.

Cited by 21 publications

References 11 publications

Evaluation of combined excimer laser and platelet‐rich plasma for the treatment of nonsegmental vitiligo: A prospective comparative study

Evaluation of combined excimer laser and platelet‐rich plasma for the treatment of nonsegmental vitiligo: A prospective comparative study

Effect of combination NSAID and NBUVB treatment in non‐photoadapters—A pilot study

Phototherapy in Pigmentary Disorders

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