Treatment of vasospasm in bacterial meningitis with hemodynamic augmentation

Jl, Sigmon; Am, Ball; Am, Namen; Kl, Tucker

doi:10.15761/ndt.1000122

Neurol Disord Therap

2017

DOI: 10.15761/ndt.1000122

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Treatment of vasospasm in bacterial meningitis with hemodynamic augmentation

Sigmon Jl¹,

Ball Am²,

Namen Am³

et al.

Abstract: Introduction Cerebrovascular complications occur in 15-20% of patients with acute bacterial meningitis infections and are associated with a poor prognosis. Arterial narrowing is the most common finding, most likely resulting from inflammation associated with meningitis. We report neurologic recovery from hemodynamic management in a patient with meningitis associated vasospasm.

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Transcranial Doppler Ultrasonographic Evaluation of Cerebrovascular Abnormalities in Children With Acute Bacterial Meningitis

et al. 2021

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Introduction: Bacterial meningitis (BM) is a global public health concern that results in significant morbidity and mortality. Cerebral arterial narrowing contributes to stroke in BM and may be amenable to intervention. However, it is difficult to diagnose in resource-limited settings where the disease is common.Methods: This was a prospective observational study from September 2015 to December 2019 in sub-Saharan Africa. Children 1 month−18 years of age with neutrophilic pleocytosis or a bacterial pathogen identified in the cerebrospinal fluid were enrolled. Transcranial Doppler ultrasound (TCD) of the middle cerebral arteries was performed daily with the aim to identify flow abnormalities consistent with vascular narrowing.Results: Forty-seven patients were analyzed. The majority had Streptococcus pneumoniae (36%) or Neisseria meningitides (36%) meningitis. Admission TCD was normal in 10 (21%). High flow with a normal pulsatility index (PI) was seen in 20 (43%) and high flow with a low PI was identified in 7 (15%). Ten (21%) had low flow. All children with a normal TCD had a good outcome. Patients with a high-risk TCD flow pattern (high flow/low PI or low flow) were more likely to have a poor outcome (82 vs. 38%, p = 0.001).Conclusions: Abnormal TCD flow patterns were common in children with BM and identified those at high risk of poor neurological outcome.

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Transcranial Doppler Ultrasonographic Evaluation of Cerebrovascular Abnormalities in Children With Acute Bacterial Meningitis

et al. 2021

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Treatment of vasospasm in bacterial meningitis with hemodynamic augmentation

Cited by 1 publication

References 5 publications

Transcranial Doppler Ultrasonographic Evaluation of Cerebrovascular Abnormalities in Children With Acute Bacterial Meningitis

Transcranial Doppler Ultrasonographic Evaluation of Cerebrovascular Abnormalities in Children With Acute Bacterial Meningitis

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