Treatment of Vasomotor Rhinitis With Intranasal Beclomethasone Dipropionate (Becotide®)

Löfkvist, Thorvald; Svensson, Gunnar

doi:10.1111/j.1398-9995.1976.tb01683.x

Cited by 31 publications

(12 citation statements)

References 12 publications

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“…A corticosteroid applied intranasally was chosen for the study as it appears to be efficient in the treatment of NANH, from both clinical experience and previous studies on the subject [5,6]. Although it has been demon strated that 400 pg/dose is more efficient than 200 pig [7,10] we used 200 pg/day in this study because we wanted to see whether the method is capable of detecting small dif ferences in responsiveness.…”

Section: Introductionmentioning

confidence: 99%

An Objective Method to Record Changes in Nasal Reactivity during Treatment of Non-Allergic Nasal Hyperreactivity

Hallén

Juto²

1994

ORL

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Non-allergic nasal hyperreactivity is a common problem and many patients suffer from daily symptoms demanding medication. Hitherto there exists no objective method to study congestional changes in clinical practice, to evaluate the efficacy of different therapies. This study is an attempt to develop a method for this purpose. Eleven patients with non-allergic nasal hyperreactivity entered the trial. A histamine challenge model with three different histamine concentrations was used. Recordings of the reactivity of the nasal mucosa were made with rhinostereometry before and after 14 days of topical treatment with budesonide 200 µg/day. The results were compared to symptom scores before and after treatment. It was found that there was a significant improvement after treatment both with regard to symptom score and to the recorded reactivity of the nasal mucosa. There was a correlation between symptom score and recorded reactivity before treatment, but not after treatment. The results indicate that the symptom score technique is sufficient in situations where only a semiquantitative method is required. However, when studying changes in the degree of hyperreactivity, the demands for an objective measuring method is greater. The study indicates that the presented method may be adapted for this purpose.

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Section: Introductionmentioning

confidence: 99%

An Objective Method to Record Changes in Nasal Reactivity during Treatment of Non-Allergic Nasal Hyperreactivity

Hallén

Juto²

1994

ORL

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“…Nasal secretion eosinophilic cells were estimated to be < 10%. The dosage was one aerosol-delivered puff into each nostril 3 times a day (300 μ g of BDP per day during the active period) [51]. …”

Section: Intranasal Corticosteroid Therapy For Vasomotor Rhinitismentioning

confidence: 99%

“…This effect remained throughout the rest of the period. For the individual nasal symptoms, a significantly lower score for the BDP period was registered for sneezing during the first week, for nasal drainage during the second week, for nasal itching during the third week, and for nasal blocking only during the fourth week of treatment (Table 4) [51]. …”

Section: Intranasal Corticosteroid Therapy For Vasomotor Rhinitismentioning

confidence: 99%

“…Of the 39 who completed the study, 25 preferred the BDP period, 5 preferred the placebo period, and 9 found no difference between the periods. The authors concluded that the results were encouraging because approximately 75% of the patients considered themselves free of trouble or improved when treated with the intranasal corticosteroid, BDP [51]. …”

Section: Intranasal Corticosteroid Therapy For Vasomotor Rhinitismentioning

confidence: 99%

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The Treatment of Vasomotor Rhinitis With Intranasal Corticosteroids

Meltzer

2009

World Allergy Organization Journal

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ObjectiveIntranasal steroids (INS) are firmly established as the therapy for choice for allergic rhinitis, but their role in vasomotor rhinitis (VMR) is not fully characterized. This review examines the potential mechanisms of action and reported efficacy of INS in patients with VMR.ResultsINS, through intracellular activation of the glucocorticoid receptor, down-regulate the recruitment and activation of inflammatory cells (T-lymphocytes, eosinophils, mast cells, basophils, neutrophils, macrophages), increase degradation of neuropeptides, and reduce epithelial cell activity, vascular permeability, and chemokine secretion. It is likely that more than vasoconstriction is responsible for the clinical effects of INS.Eight INS can be prescribed for rhinitis in the US; only 4 have been studied for VMR. Seventy-four percent of patients treated with beclomethasone dipropionate considered themselves symptom-free or greatly improved versus 31% with placebo. Budesonide significantly reduced rhinitis symptoms and methacholine-induced nasal secretions compared with placebo. Fluticasone propionate compared with placebo provided significantly greater relief from nasal obstruction; computed tomographic scans showed significant reductions in the mucosal area of the lower turbinates. Mometasone furoate produced numerically better rhinitis symptom scores and, when discontinued, lower relapse rates than placebo.ConclusionData supports INS as beneficial pharmacotherapy for VMR.

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“…Fven in patients suffering from nonallergic perennial rhinitis, GCSs offer an effective treatment of nasal symptoms (8,63,90,92,144). The presence of eosinophils in a nasal smear before treatment seems to indicate a high degree of GCS responsiveness in terms of symptomatic relief (8,50,158).…”

Section: Perennial Rhinitismentioning

confidence: 99%

Glucocorticosteroids and rhinitis

Mygind

1993

Allergy

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Treatment of Vasomotor Rhinitis With Intranasal Beclomethasone Dipropionate (Becotide®)

Cited by 31 publications

References 12 publications

An Objective Method to Record Changes in Nasal Reactivity during Treatment of Non-Allergic Nasal Hyperreactivity

An Objective Method to Record Changes in Nasal Reactivity during Treatment of Non-Allergic Nasal Hyperreactivity

The Treatment of Vasomotor Rhinitis With Intranasal Corticosteroids

Glucocorticosteroids and rhinitis

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