Treatment of vasculitis.

Taylor, Henry Osborn; Samanta, A.

doi:10.1111/j.1365-2125.1993.tb05674.x

Cited by 17 publications

(13 citation statements)

References 143 publications

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“…Systemic manifestations of LCV are much less common than its dermatologic features. These include fever, microscopic hematuria, elevated creatinine, pericarditis and pleuritis [ 1 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Severe leukocytoclastic vasculitis secondary to the use of a naproxen and requiring amputation: a case report

2010

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IntroductionLeukocytoclastic vasculitis (also known as hypersensitivity vasculitis and cutaneous necrotizing vasculitis) can present with various manifestations, which often delays the diagnosis and treatment. In order to show the importance of the early recognition of leukocytoclastic vasculitis, we present a case which occurred secondary to the use of a common pharmaceutical, naproxen. We were unable to find a case of leukocytoclastic vasculitis secondary to naproxen in the literature.Case presentationWe present the case of a 33-year-old African American woman with below the knee and bilateral digital gangrene from hypersensitivity vasculitis secondary to the non-steroidal anti-inflammatory medication naproxen.ConclusionThis is an original case report focusing on the rheumatologic management of leukocytoclastic vasculitis. However, other specialties, such as internal medicine, dermatology, infectious disease, general surgery and pathology, can gain valuable information by reviewing this case report. Reporting a case of leukocytoclastic vasculitis secondary to treatment with naproxen will advance our understanding of this disease etiology by adding yet another non-steroidal anti-inflammatory drug to the list of potential causes of leukocytoclastic vasculitis.

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“…Systemic manifestations of LCV are much less common than its dermatologic features. These include fever, microscopic hematuria, elevated creatinine, pericarditis and pleuritis [ 1 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Severe leukocytoclastic vasculitis secondary to the use of a naproxen and requiring amputation: a case report

2010

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“…LCV typically follows a single, episodic, self‐limiting disease course, with symptoms lasting up to 4 weeks ; thus, it can be initially managed expectantly. For those with widespread or recurrent disease, oral corticosteroids such as prednisolone are frequently used . Colchicine has also been reported to be effective, particularly in those patients with extracutaneous manifestations .…”

Section: Discussionmentioning

confidence: 99%

“…For those with widespread or recurrent disease, oral corticosteroids such as prednisolone are frequently used . Colchicine has also been reported to be effective, particularly in those patients with extracutaneous manifestations . Overall, LCV carries a generally good prognosis.…”

Section: Discussionmentioning

confidence: 99%

A not‐so‐sweet diagnosis – leukocytoclastic vasculitis masquerading as squamous cell carcinoma

Mensa

Jessop

Wilson-Jones

et al. 2016

International Wound Journal

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Leukocytoclastic vasculitis (LCV) is a rare small-vessel vasculitis characterised by neutrophilic inflammation of post-capillary venules. Incidence varies from 3 to 4.5 per 100 000 people per year. Patients typically present with painful, itchy purpura and erythema, although clinical manifestations can vary making diagnosis a challenge. We report the case of a 75-year-old man with a history of a previously completely excised and grafted squamous cell carcinoma (SCC) on the dorsum of his hand, who presented with an acutely swollen, erythematous and ulcerated lesion adjacent to the graft site. A shave biopsy failed to definitively exclude SCC recurrence. He was referred to the Plastics team who initially suspected Sweet's syndrome but could not rule out SCC recurrence. The patient underwent formal mapping incisional biopsies that later diagnosed LCV. He was managed conservatively and made an excellent recovery. We present clinical photographs and histology to illustrate disease progression. LCV is typically self-limiting with a good overall prognosis, but a minority of patients follow a protracted course, which may require treatment in the form of systemic corticosteroids or colchicine. LCV can only be confirmed histologically. We present this case in order to highlight the importance of adequate tissue biopsy when there is diagnostic uncertainty with an acute dermatosis, particularly in the context of previous skin malignancy.

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“…These include fever, microscopic hematuria, elevated creatinine, pericarditis and pleuritis. 1,8 Numerous series and case reports have reported drugs as the precipitating agent in LCV. 1,7,9 In patients with biopsy proven LCV, 24% had drug exposure within a week of presentation.…”

Section: Discussionmentioning

confidence: 99%

“…Most cases of LCV are self-limited, lasting several weeks to months. 9 One study showed that 90% of patients with HSV had resolution of symptoms in less than one year 1,8 . Also, most patients with LCV have complete recovery without sequelae.…”

Section: Discussionmentioning

confidence: 99%

Leucocytoclastic Vasculitis: A Rare Cause of Palpable Purpura

et al. 2012

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Leucocytoclastic vasculitis (LCV) is an isolated condition without systemic vasculitis or glomerulonephritis. The skin is the most commonly involved organ in LCV, predominantly in the lower extremities. The most common skin manifestation is palpable purpura. Some patients may have arthralgias or arthritis as the presenting symptom, usually oligoarthritis of the knees or ankles. The inflammation of small blood vessels, most commonly postcapillary venules, is the cardinal histologic feature of LCV. A16-year-old male admitted into our medicine unit with palpable purpura. He was diagnosed as leukocytoclastic vasculitisof unidentified etiology on the basis of clinical conditions, laboratory tests, and histopathological analysis. Most important cause of LCV is drugs. So, we report this case to increase the awareness of indiscriminate use of medicine which can case this problems. DOI: http://dx.doi.org/10.3329/jom.v13i2.12770 J Medicine 2012; 13 : 240-242

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Treatment of vasculitis.

Cited by 17 publications

References 143 publications

Severe leukocytoclastic vasculitis secondary to the use of a naproxen and requiring amputation: a case report

Severe leukocytoclastic vasculitis secondary to the use of a naproxen and requiring amputation: a case report

A not‐so‐sweet diagnosis – leukocytoclastic vasculitis masquerading as squamous cell carcinoma

Leucocytoclastic Vasculitis: A Rare Cause of Palpable Purpura

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